Guest guest Posted March 31, 2006 Report Share Posted March 31, 2006 - you may want to check out a website called Understanding Your Tests- I've used it to help to understand my daughters labs results- the web site address is www.labtestsonline.org/understanding/index.html Sue Petrelli Mom to 14 yr old CVIDer jmfritze <jmfritze@...> wrote: Ok, so I finally got a copy of Ana's lab results and I was wondering if I post the numbers here if you guys can give me your Ana 14 mo This forum is open to parents and caregivers of children diagnosed with a Primary Immune Deficiency. Opinions or medical advice stated here are the sole responsibility of the poster and should not be taken as professional advice. To unsubscribe -unsubscribegroups (DOT) To search group archives go to: /messages Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 31, 2006 Report Share Posted March 31, 2006 Thanks Sue, I'll take a look at it! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 31, 2006 Report Share Posted March 31, 2006 Let me tell you what happened with . We would run the tests and he would be borderline low and run it again in 30 days and he would be normal. I think that with the infection in full force you won't get an accurate reading but then again that is just my opinion. Cassie jmfritze wrote: > Ok, so I finally got a copy of Ana's lab results and I was wondering > if I post the numbers here if you guys can give me your opinions. I > am wondering if they look right to you, by right I mean normal > enough to call her " cured " and not even look at her for six months. > Also, the immunization responses don't give ranges, so I am > wondering how I know if they were interpreted correctly. And there > is some stuff that is high (in her t-cell counts) that I dont' know > if it is a big deal or not. Thanks! > > Platelet 634 (150-450) (always high, still never have gotten an > explanation) > MPV 5.9 (7.4-10.4) > > IgG sub 1 297 (286-680) > IgG sub 2 38 (30-327) > IgG sub 3 27 (13-82) > IgG sub 4 0 (1-65) > IgG 363 (331-1165) > IgE <4.5 (0-60) > > CD3+ T-CELLS 62% (74-74) > CD4+/CD3+ HELPER 41 (39-49) > CD8+/CD3+ SUPPRESSOR 14 (17-31) > CD19+ (BCELLS) 26 (16-28) > CD16+56+/CD3-NK CELLS 10 (3-9) > CD3+ ABSOLUTE 6422 (1100-5000) > CD4+/CD3+ ABSOLUTE 4254 (800-3000) > CD8+/CD3- ABSOLUTE 1486 (500-2700) > CD19+ ABSOLUTE 2680 (500-1800) > CD16+56+/CD3- 1065 (100-500) > CD4:CD8 RATIO 2.86 (.5-2.7) > > Mumps status negative > rubella IgG positive > Rubeola status positive > diphtheria 1.69 > Tetanus .72 > > There is also this list of things (phytohemagglutinin levels 1-4, > pokeweed level 1-4, concanavalin A level 1-4) which I have no clue > as to what they are. > > As a reference, when the blood was drawn Ana was on day 18 of a 20 > run of ceftin for ear infection. On that day the doctor said the > infection and fluid were gone but the eardrums still looked " sucked > in " on both sides. Her WBC was slightly elevated. > > If you have read this far you're wonderful...thanks for any input > you can give! I am way to naive at this stuff. > > > Ana 14 mo > > > > > > This forum is open to parents and caregivers of children diagnosed > with a Primary Immune Deficiency. Opinions or medical advice stated > here are the sole responsibility of the poster and should not be taken > as professional advice. > > To unsubscribe -unsubscribegroups (DOT) > To search group archives go to: > /messages > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 31, 2006 Report Share Posted March 31, 2006 - Immune studies are so difficult to read but many of the parents here may be able to help. Give them a chance to chime in... Here are a couple things to clarify: 1. Is MPV mean platelet volume? If so, this may need to be evaluated. I don't know whether or not the is related to immune status and/or infection. How are her other blood indicators such as hemaglobin? Ferritin or iron status? MPV 5.9 (7.4-10.4) What is going on with her albumin? I thought you said it was low at one point. 2. From what you post, it appears like she is borderline or low with some subclasses. These may naturally increase with age -- but I don't know about this with FTT and all of her long courses of antibiotics for infections. IgG sub 1 297 (286-680) IgG sub 2 38 (30-327) IgG sub 3 27 (13-82) IgG sub 4 0 (1-65) Children's Hospital Los Angeles' " Normal " is > 400 for total IgG. I think that standard deviations from the " average " is what matters, though. And, obviously, the clinical picture as well. Every hospital has slightly different ranges of " normal " . IgG 363 (331-1165) 3. With IgE this low, you can not test for allergies. A high IgE is indicative of allergies, parasitic infections, among other things. Scientists still do not know what to make of low IgEs -- it does not mean " great " it means " we just don't know " . But, we do know that with IgE this low you absolutely will not get accurate IgE based (e.g., RAST) allergy tests. IgE <4.5 (0-60) 4. ???? Sorry. You really need an immuno that will sit down with you are explain this stuff. Looks like a couple subsets are low or borderline. I don't think it is logical to ignore the low numbers here. CD3+ T-CELLS 62% (74-74) CD4+/CD3+ HELPER 41 (39-49) CD8+/CD3+ SUPPRESSOR 14 (17-31) CD19+ (BCELLS) 26 (16-28) CD16+56+/CD3-NK CELLS 10 (3-9) CD3+ ABSOLUTE 6422 (1100-5000) CD4+/CD3+ ABSOLUTE 4254 (800-3000) CD8+/CD3- ABSOLUTE 1486 (500-2700) CD19+ ABSOLUTE 2680 (500-1800) CD16+56+/CD3- 1065 (100-500) 5. This one looks odd to me. Ask the group what this ratio means. I don't want to confuse you but I think that this high of a ratio may be indicative of something. CD4:CD8 RATIO 2.86 (.5-2.7) 6. Was the titer to mumps negative? Mumps status negative rubella IgG positive Rubeola status positive 7. I am not sure about these. diphtheria 1.69 Tetanus .72 8. " There is also this list of things (phytohemagglutinin levels 1-4, pokeweed level 1-4, concanavalin A level 1-4) which I have no clue as to what they are. " This is mitogen response or T-cell response " stuff " in the environment. There should also be antigen (protein or organisms) response -- another type of T-cell response to things that you are suppose to develop antibodies to. Were antigen studies run or just mitogen? 9. " the blood was drawn Ana was on day 18 of a 20 run of ceftin for ear infection. On that day the doctor said the infection and fluid were gone but the eardrums still looked " sucked in " on both sides. " You have some clinical issues going on. Log everything. 10. " Her WBC was slightly elevated " -- which could very well mean that the IgG levels were high for Ana. 11. *****Where is her IgM level?******** " If you have read this far you're wonderful...thanks for any input you can give! " I would call IDF, lung line (Dr. Gelfand's people), and consider another eval. We are still here for you. <smile> mom CVIDer This forum is open to parents and caregivers of children diagnosed with a Primary Immune Deficiency. Opinions or medical advice stated here are the sole responsibility of the poster and should not be taken as professional advice. To unsubscribe -unsubscribegroups (DOT) To search group archives go to: /messages Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 1, 2006 Report Share Posted April 1, 2006 Thanks for the input.... > 1. Is MPV mean platelet volume? If so, this may need to be evaluated. I don't know whether or not the is related to immune status and/or infection. How are her other blood indicators such as hemaglobin? Ferritin or iron status? > >---Yes this is mean platelet volume. I have never understood why this is low and the count is high but it always is. What kind of doctor could explain this to me? Her hemaglobin is always fine, I don't see her ferritin or iron on any of her bloodwork. > What is going on with her albumin? I thought you said it was low at one point. ----------Her albumin has been up and down, with the latest blood work it was normal. > > 2. From what you post, it appears like she is borderline or low with some subclasses. ------Ok, can subclasses go up with infection? If she is healthy would they go back down? And would my increased nursing raise them? > I don't think it is logical to ignore the low numbers here. > ---This is what they want to recheck in six months.. This one looks odd to me. Ask the group what this ratio means. I don't want to confuse you but I think that this high of a ratio may be indicative of something. > CD4:CD8 RATIO 2.86 (.5-2.7) -------I have yet to find what this ratio means, but it is consistently high. > > 6. Was the titer to mumps negative? >-------Yes it was negative, is it normal for some to respond and some not to? > > 8. " There is also this list of things (phytohemagglutinin levels 1-4, pokeweed level 1-4, concanavalin A level 1-4) which I have no clue as to what they are. " > > This is mitogen response or T-cell response " stuff " in the environment. There should also be antigen (protein or organisms) response -- another type of T-cell response to things that you are suppose to develop antibodies to. Were antigen studies run or just mitogen? ---------I think just the mitogen, at least I don't see anything else. How do I know if the numbers are within normal ranges?? > 11. *****Where is her IgM level?******** >------This doc doesn't recheck her IgM or IgA, she says if Ana had them, which she did twice when they checked them, and they were in the normal range, they will stay there, so she doesn't recheck them, though I thought I asked her to. > > I would call IDF, lung line (Dr. Gelfand's people), and consider another eval. -------I think I will get a second opinion. But I don't know where to go, maybe I will call Dr. Shapiro's office here in the cities. But I have heard he is very busy, I'm afraid it will take months to get her in, but I suppose that will happen anywhere we go. But I get so hopeful because she hasn't had an infection in two weeks and she has gained another few ounces I think. Maybe if I just wait they will prove to be right? But I don't want to waste time waiting if she is not ok. > > We are still here for you. <smile> > --------Thanks so much. I'm so confused. But you are wonderful! > Ana 14 mo Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 1, 2006 Report Share Posted April 1, 2006 How high are her platelets? 's get as high as 506,000 and no one is ever concerned (Hematologist/blood doctor or the ped) They don't become concerned until they get a lot higher. The normal range for children is 150,000-400,000. Labs often use a lower limit for the normal range, when in reality 400,000 -450,000 is the upper limit for children (Diagnostics-Springhouse 1998 & 2001 editions say 400,000 see also: http://www.fpnotebook.com/HEM111.htm this site lists 450,000 as the upper limit) Platelets can be elevated due to inflammation, infection and iron deficiency anemia to name a few things. When looking at anemia, several things need to be considered (all the RBC indices MCV, MCHC, MCH, hematocrit, hemoglobin and total RBC), they also look at the RDW -- just noting this so in case you worry about anemia. If you go to the Shwachman-Diamond America page www.shwachmandiamondamerica.org <http://www.shwachmandiamondamerica.org/> we have a blood forum on our community message board. We've got links to several things there. Used to have more-but a hacker destroyed it! SIGH.. It is getting back to normal now. My boys have their iron stores checked when they have their bone marrow biopsies-and they don't have any stainable iron stores. This is expected with their disease. Mean Platelet Volume (MPV) is a measurement of the average size of platelets <http://en.wikipedia.org/wiki/Platelets> found in blood and is typically included in blood tests. Since the average platelet size is larger when the body is producing increased numbers of platelets, MPV test results can be used to make inferences about platelet production in bone marrow. We have more links to MPV on the message board. Peace Be With You, Pattie Don't let your past dictate who you are now, but let it be a part of who you will become. _____ Thanks for the input.... > 1. Is MPV mean platelet volume? If so, this may need to be evaluated. I don't know whether or not the is related to immune status and/or infection. How are her other blood indicators such as hemaglobin? Ferritin or iron status? > >---Yes this is mean platelet volume. I have never understood why this is low and the count is high but it always is. What kind of doctor could explain this to me? Her hemaglobin is always fine, I don't see her ferritin or iron on any of her bloodwork. _____ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 1, 2006 Report Share Posted April 1, 2006 > How high are her platelets? They range from 550-700 usually, with low platelet volume. It confuses me. Thanks for the links, I will check it out. Ana 14 mo Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 1, 2006 Report Share Posted April 1, 2006 -------I think I will get a second opinion. But I don't know where to go, maybe I will call Dr. Shapiro's office here in the cities. But I have heard he is very busy, I'm afraid it will take months to get her in, but I suppose that will happen anywhere we go. But I get so hopeful because she hasn't had an infection in two weeks and she has gained another few ounces I think. Maybe if I just wait they will prove to be right? But I don't want to waste time waiting if she is not ok. <<Give him a call. He knows his stuff. He has expanded his practice and is far less hard to get an appointment with than he was in the beginning. Pam mom to 4 Rebekah, 6, CVID and ?? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 1, 2006 Report Share Posted April 1, 2006 > > <<Give him a call. He knows his stuff. > Pam, Thanks, I'll see if I can find him. Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.