Re: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in H

[Guest guest]

Good article Liz,, but I have one comment,, and of course you knew I would have one comment,, lol,, First off, IF you read the conclusion, it said it did not produce a significant effect against the anemia,, Natural substances wont give the same kind of effect that chemicals have , one should NOT EXPECT it to do the same as procrit.. but it doesnt have the side effects that procrit have either.. procrit didnt work very well for me, it managed to keep me from falling further ,, but did not raise my hemoglobin at all,, so I dont think that one would expect that AO's would cause a huge raise in hemo-g's or RBC's.. but might help maintain it from falling faster,, so the study is not accurate in what its expecting.. and Second,, I wonder IF they used REAL or synthetic vit E.. there is a huge difference and the body does NOT recognize synthetic E as E at all.. most studies use synthetic E because its so much cheaper than real E... I WISH they would do a

REAL study with REAL vitamin E,, and use all the different kinds of vit e... then they would have real answers.. love ya sis, jaxelizabethnv1 <elizabethnv1@...> wrote: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in HCV Patients Treated with Pegylated Interferon Alfa-2b (Peg-Intron) and RibavirinRibavirin is commonly used in combination with pegylated interferon alfa to treat patients with chronic hepatitis C (HCV). Ribavirin can cause hemolysis and a decrease in hemoglobin (Hb) levels is common. The mechanism of ribavirin-induced hemolysis is uncertain, but an increased susceptibility of erythrocytes (RBC) to membrane oxidative damage may play a role. The aim of the present study was to test whether antioxidant (AO) treatment would

ameliorate the fall in Hb levels in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) and ribavirin. A randomized, prospective, open-label study was designed to study the effects of AO treatment (vitamin E, 400 IU BID; vitamin C, 500 mg BID; S-adenosyl-L-methionine, 400 mg TID) in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) 1.5 mcg/kg QW) and ribavirin (800-1400 mg QD). Treatment-naive, non-smoking patients with chronic HCV were divided into two groups: the AO group (n=17) received AO for a total of 28 w beginning 4 w before antiviral therapy, while the control group (n=24) received antiviral therapy alone. This report focuses on measurements made at entry (6 w prior to antiviral therapy) and at 2, 4 or 12 w of antiviral therapy. RBC levels of malondialdehyde (MDA, a lipid peroxidation product) and glutathione (GSH) were also measured. Results The control and

AO groups were well matched with respect to age (47 ± 1 vs 49 ± 2), gender (67% vs 59% male), race (83% vs 94% Caucasian), HCV genotype (79% vs 94% type 1), and baseline Hb levels (15.2 ± 0.3 vs 15.1 ± 0.3 g/dL). Antiviral therapy for 12 w resulted in decreases in ALT activity (-60 ± 10 U/L), platelets (-45 ± 9/mm3), white blood cells (-2.8 ± 0.4/mm3) and haptoglobin (-20 ± 10 mg/dL), and an increase in retiulocytes (+1.4 ± 0.4%): none of these effects was significantly changed by AO. RBC levels of MDA and GSH were not significantly altered by either antiviral therapy or AO. In addition, AO did not significantly ameliorate the fall in Hb levels produced by antiviral therapy after 2, 4 or 12 w of treatment. Use of recombinant erythropoietin was similar in both groups (17% vs 12%). Conclusion The authors conclude, "This regimen of AO treatment with vitamin E, vitamin C and S-adenosyl-L-methionine

did not substantially ameliorate the fall in Hb levels in HCV patients during the first 12 w of therapy with pegylated interferon alfa-2b and ribavirin."Jackie

[Guest guest]

LOL yeah I expected you to find something to say about this ,hehe love ya girl

Re: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in H

Good article Liz,, but I have one comment,, and of course you knew I would have one comment,, lol,,

First off, IF you read the conclusion, it said it did not produce a significant effect against the anemia,, Natural substances wont give the same kind of effect that chemicals have , one should NOT EXPECT it to do the same as procrit.. but it doesnt have the side effects that procrit have either.. procrit didnt work very well for me, it managed to keep me from falling further ,, but did not raise my hemoglobin at all,, so I dont think that one would expect that AO's would cause a huge raise in hemo-g's or RBC's.. but might help maintain it from falling faster,, so the study is not accurate in what its expecting.. and Second,, I wonder IF they used REAL or synthetic vit E.. there is a huge difference and the body does NOT recognize synthetic E as E at all.. most studies use synthetic E because its so much cheaper than real E...

I WISH they would do a REAL study with REAL vitamin E,, and use all the different kinds of vit e... then they would have real answers..

love ya sis,

jaxelizabethnv1 <elizabethnv1@...> wrote:

Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in HCV Patients Treated with Pegylated Interferon Alfa-2b (Peg-Intron) and RibavirinRibavirin is commonly used in combination with pegylated interferon alfa to treat patients with chronic hepatitis C (HCV). Ribavirin can cause hemolysis and a decrease in hemoglobin (Hb) levels is common. The mechanism of ribavirin-induced hemolysis is uncertain, but an increased susceptibility of erythrocytes (RBC) to membrane oxidative damage may play a role. The aim of the present study was to test whether antioxidant (AO) treatment would ameliorate the fall in Hb levels in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) and ribavirin. A randomized, prospective, open-label study was designed to study the effects of AO treatment (vitamin E, 400 IU BID; vitamin C, 500 mg BID; S-adenosyl-L-methionine, 400 mg TID) in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) 1.5 mcg/kg QW) and ribavirin (800-1400 mg QD). Treatment-naive, non-smoking patients with chronic HCV were divided into two groups: the AO group (n=17) received AO for a total of 28 w beginning 4 w before antiviral therapy, while the control group (n=24) received antiviral therapy alone. This report focuses on measurements made at entry (6 w prior to antiviral therapy) and at 2, 4 or 12 w of antiviral therapy. RBC levels of malondialdehyde (MDA, a lipid peroxidation product) and glutathione (GSH) were also measured. Results The control and AO groups were well matched with respect to age (47 ± 1 vs 49 ± 2), gender (67% vs 59% male), race (83% vs 94% Caucasian), HCV genotype (79% vs 94% type 1), and baseline Hb levels (15.2 ± 0.3 vs 15.1 ± 0.3 g/dL). Antiviral therapy for 12 w resulted in decreases in ALT activity (-60 ± 10 U/L), platelets (-45 ± 9/mm3), white blood cells (-2.8 ± 0.4/mm3) and haptoglobin (-20 ± 10 mg/dL), and an increase in retiulocytes (+1.4 ± 0.4%): none of these effects was significantly changed by AO. RBC levels of MDA and GSH were not significantly altered by either antiviral therapy or AO. In addition, AO did not significantly ameliorate the fall in Hb levels produced by antiviral therapy after 2, 4 or 12 w of treatment. Use of recombinant erythropoietin was similar in both groups (17% vs 12%). Conclusion The authors conclude, "This regimen of AO treatment with vitamin E, vitamin C and S-adenosyl-L-methionine did not substantially ameliorate the fall in Hb levels in HCV patients during the first 12 w of therapy with pegylated interferon alfa-2b and ribavirin."Jackie

[Guest guest]

LOL yeah I expected you to find something to say about this ,hehe love ya girl

Re: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in H

Good article Liz,, but I have one comment,, and of course you knew I would have one comment,, lol,,

First off, IF you read the conclusion, it said it did not produce a significant effect against the anemia,, Natural substances wont give the same kind of effect that chemicals have , one should NOT EXPECT it to do the same as procrit.. but it doesnt have the side effects that procrit have either.. procrit didnt work very well for me, it managed to keep me from falling further ,, but did not raise my hemoglobin at all,, so I dont think that one would expect that AO's would cause a huge raise in hemo-g's or RBC's.. but might help maintain it from falling faster,, so the study is not accurate in what its expecting.. and Second,, I wonder IF they used REAL or synthetic vit E.. there is a huge difference and the body does NOT recognize synthetic E as E at all.. most studies use synthetic E because its so much cheaper than real E...

I WISH they would do a REAL study with REAL vitamin E,, and use all the different kinds of vit e... then they would have real answers..

love ya sis,

jaxelizabethnv1 <elizabethnv1@...> wrote:

Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in HCV Patients Treated with Pegylated Interferon Alfa-2b (Peg-Intron) and RibavirinRibavirin is commonly used in combination with pegylated interferon alfa to treat patients with chronic hepatitis C (HCV). Ribavirin can cause hemolysis and a decrease in hemoglobin (Hb) levels is common. The mechanism of ribavirin-induced hemolysis is uncertain, but an increased susceptibility of erythrocytes (RBC) to membrane oxidative damage may play a role. The aim of the present study was to test whether antioxidant (AO) treatment would ameliorate the fall in Hb levels in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) and ribavirin. A randomized, prospective, open-label study was designed to study the effects of AO treatment (vitamin E, 400 IU BID; vitamin C, 500 mg BID; S-adenosyl-L-methionine, 400 mg TID) in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) 1.5 mcg/kg QW) and ribavirin (800-1400 mg QD). Treatment-naive, non-smoking patients with chronic HCV were divided into two groups: the AO group (n=17) received AO for a total of 28 w beginning 4 w before antiviral therapy, while the control group (n=24) received antiviral therapy alone. This report focuses on measurements made at entry (6 w prior to antiviral therapy) and at 2, 4 or 12 w of antiviral therapy. RBC levels of malondialdehyde (MDA, a lipid peroxidation product) and glutathione (GSH) were also measured. Results The control and AO groups were well matched with respect to age (47 ± 1 vs 49 ± 2), gender (67% vs 59% male), race (83% vs 94% Caucasian), HCV genotype (79% vs 94% type 1), and baseline Hb levels (15.2 ± 0.3 vs 15.1 ± 0.3 g/dL). Antiviral therapy for 12 w resulted in decreases in ALT activity (-60 ± 10 U/L), platelets (-45 ± 9/mm3), white blood cells (-2.8 ± 0.4/mm3) and haptoglobin (-20 ± 10 mg/dL), and an increase in retiulocytes (+1.4 ± 0.4%): none of these effects was significantly changed by AO. RBC levels of MDA and GSH were not significantly altered by either antiviral therapy or AO. In addition, AO did not significantly ameliorate the fall in Hb levels produced by antiviral therapy after 2, 4 or 12 w of treatment. Use of recombinant erythropoietin was similar in both groups (17% vs 12%). Conclusion The authors conclude, "This regimen of AO treatment with vitamin E, vitamin C and S-adenosyl-L-methionine did not substantially ameliorate the fall in Hb levels in HCV patients during the first 12 w of therapy with pegylated interferon alfa-2b and ribavirin."Jackie

[Guest guest]

Liz, Jax, why is it that "real" vitamine E is so expensive? Don't we get Vit. E naturally eating fish? If I'm wrong here, where is a good source of Vit E that can be added to the diet? Thanks in advance, Love to all, Eat well, sleep well, be well!Jackie on <redjaxjm@...> wrote: Good article Liz,, but I have one comment,, and of course you knew I would have one comment,, lol,, First off, IF you read the conclusion, it said it did not produce a significant effect against the anemia,, Natural substances wont give the same kind of effect that chemicals have , one should NOT EXPECT it to do the same as procrit.. but it doesnt have the side effects that procrit have either.. procrit didnt work very well for me, it managed to keep me from falling

further ,, but did not raise my hemoglobin at all,, so I dont think that one would expect that AO's would cause a huge raise in hemo-g's or RBC's.. but might help maintain it from falling faster,, so the study is not accurate in what its expecting.. and Second,, I wonder IF they used REAL or synthetic vit E.. there is a huge difference and the body does NOT recognize synthetic E as E at all.. most studies use synthetic E because its so much cheaper than real E... I WISH they would do a REAL study with REAL vitamin E,, and use all the different kinds of vit e... then they would have real answers.. love ya sis, jaxelizabethnv1 <elizabethnv1@...> wrote: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in HCV Patients Treated with Pegylated Interferon Alfa-2b

(Peg-Intron) and RibavirinRibavirin is commonly used in combination with pegylated interferon alfa to treat patients with chronic hepatitis C (HCV). Ribavirin can cause hemolysis and a decrease in hemoglobin (Hb) levels is common. The mechanism of ribavirin-induced hemolysis is uncertain, but an increased susceptibility of erythrocytes (RBC) to membrane oxidative damage may play a role. The aim of the present study was to test whether antioxidant (AO) treatment would ameliorate the fall in Hb levels in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) and ribavirin. A randomized, prospective, open-label study was designed to study the effects of AO treatment (vitamin E, 400 IU BID; vitamin C, 500 mg BID; S-adenosyl-L-methionine, 400 mg TID) in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) 1.5 mcg/kg QW) and ribavirin (800-1400 mg QD). Treatment-naive, non-smoking

patients with chronic HCV were divided into two groups: the AO group (n=17) received AO for a total of 28 w beginning 4 w before antiviral therapy, while the control group (n=24) received antiviral therapy alone. This report focuses on measurements made at entry (6 w prior to antiviral therapy) and at 2, 4 or 12 w of antiviral therapy. RBC levels of malondialdehyde (MDA, a lipid peroxidation product) and glutathione (GSH) were also measured. Results The control and AO groups were well matched with respect to age (47 ?1 vs 49 ?2), gender (67% vs 59% male), race (83% vs 94% Caucasian), HCV genotype (79% vs 94% type 1), and baseline Hb levels (15.2 ?0.3 vs 15.1 ?0.3 g/dL). Antiviral therapy for 12 w resulted in decreases in ALT activity (-60 ?10 U/L), platelets (-45 ?9/mm3), white blood cells (-2.8 ?0.4/mm3) and haptoglobin (-20 ?10 mg/dL), and an increase in retiulocytes (+1.4 ?0.4%): none of these effects

was significantly changed by AO. RBC levels of MDA and GSH were not significantly altered by either antiviral therapy or AO. In addition, AO did not significantly ameliorate the fall in Hb levels produced by antiviral therapy after 2, 4 or 12 w of treatment. Use of recombinant erythropoietin was similar in both groups (17% vs 12%). Conclusion The authors conclude, "This regimen of AO treatment with vitamin E, vitamin C and S-adenosyl-L-methionine did not substantially ameliorate the fall in Hb levels in HCV patients during the first 12 w of therapy with pegylated interferon alfa-2b and ribavirin."Jackie

New Messenger with Voice. Call regular phones from your PC and save big.

[Guest guest]

Vegetable Oils are Natural Sources of Vitamin E ( wheatgerm is also a high source)

Many people argue that it is not necessary to take pills or capsules of vitamins because you can get your vitamins and much more from the foods you normally eat. It is hard to argue against the "natural is better" point of view. It is of course very difficult for those of us who are forced to eat on the run and have to eat only what we can hold in one hand to get our share of essential nutrients each day. Added to this is the fact that when studies show health benefits of such things as vitamins, it is often at intake levels beyond what is normally accepted as adequate for proper nutrition.

Vitamin E is a nutrient that is constantly in the news these days, mainly because of its antioxidant properties. The whole topic of vitamin E is complicated by the fact that there are eight chemically related compounds - called isomers - that are often lumped together and called vitamin E. d-alpha-tocopherol is the shorter and easier way of referring to [2R-2R*(4R*,8R*)]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1- benzopyran-6-0l or vitamin E. In many of the foods we eat we find alpha-tocopherol and in addition beta-tocopherol, delta-tocopherol, gamma-tocopherol and esters of alpha-tocoperol. All of these compounds have "vitamin E activity" in the classical sense, but are not as potent as alpha-tocopherol. However, as far as its antioxidant effectiveness goes, alpha-tocopherol is often not as good as the other forms of vitamin E. It is widely accepted that delta is a better antioxidant than gamma which is better than beta which is better than alpha.

So how can you increase your intake of vitamin E? Generally oilseeds (canola, soybean, corn, safflower and cottonseed ) and their products (vegetable oils or margarines) are good sources of vitamin E. But as the table below shows, vegetable oils contain a mixture of the different chemical forms of tocopherol.

TOCOPHEROL CONTENT OF VARIOUS VEGETABLE OILS (mg/kg)

Oil

alpha

beta

gamma

delta

Soybean

116

34

737

275

Sunflower

608

17

11

-

Olive

93

-

7.3

-

Canola

192

-

431

40

Most food labels are not detailed enough to report the different isomers of vitamin E and so the value quoted on the label is either for only alpha-tocopherol or it may be for the total of all vitamin E compounds. It depends on how the analyses were carried out. It is probably best to use a variety of oils in the diet to make sure that you are getting at least some of all the different forms of vitamin E. Vegetable oils still are one of the best sources of vitamin E in the diet.

Re: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in H

Liz, Jax, why is it that "real" vitamine E is so expensive? Don't we get Vit. E naturally eating fish? If I'm wrong here, where is a good source of Vit E that can be added to the diet?

Thanks in advance,

Love to all,

Chris

Eat well, sleep well, be well!Jackie on <redjaxjm@...> wrote:

Good article Liz,, but I have one comment,, and of course you knew I would have one comment,, lol,,

First off, IF you read the conclusion, it said it did not produce a significant effect against the anemia,, Natural substances wont give the same kind of effect that chemicals have , one should NOT EXPECT it to do the same as procrit.. but it doesnt have the side effects that procrit have either.. procrit didnt work very well for me, it managed to keep me from falling further ,, but did not raise my hemoglobin at all,, so I dont think that one would expect that AO's would cause a huge raise in hemo-g's or RBC's.. but might help maintain it from falling faster,, so the study is not accurate in what its expecting.. and Second,, I wonder IF they used REAL or synthetic vit E.. there is a huge difference and the body does NOT recognize synthetic E as E at all.. most studies use synthetic E because its so much cheaper than real E...

I WISH they would do a REAL study with REAL vitamin E,, and use all the different kinds of vit e... then they would have real answers..

love ya sis,

jaxelizabethnv1 <elizabethnv1@...> wrote:

Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in HCV Patients Treated with Pegylated Interferon Alfa-2b (Peg-Intron) and RibavirinRibavirin is commonly used in combination with pegylated interferon alfa to treat patients with chronic hepatitis C (HCV). Ribavirin can cause hemolysis and a decrease in hemoglobin (Hb) levels is common. The mechanism of ribavirin-induced hemolysis is uncertain, but an increased susceptibility of erythrocytes (RBC) to membrane oxidative damage may play a role. The aim of the present study was to test whether antioxidant (AO) treatment would ameliorate the fall in Hb levels in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) and ribavirin. A randomized, prospective, open-label study was designed to study the effects of AO treatment (vitamin E, 400 IU BID; vitamin C, 500 mg BID; S-adenosyl-L-methionine, 400 mg TID) in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) 1.5 mcg/kg QW) and ribavirin (800-1400 mg QD). Treatment-naive, non-smoking patients with chronic HCV were divided into two groups: the AO group (n=17) received AO for a total of 28 w beginning 4 w before antiviral therapy, while the control group (n=24) received antiviral therapy alone. This report focuses on measurements made at entry (6 w prior to antiviral therapy) and at 2, 4 or 12 w of antiviral therapy. RBC levels of malondialdehyde (MDA, a lipid peroxidation product) and glutathione (GSH) were also measured. Results The control and AO groups were well matched with respect to age (47 ?1 vs 49 ?2), gender (67% vs 59% male), race (83% vs 94% Caucasian), HCV genotype (79% vs 94% type 1), and baseline Hb levels (15.2 ?0.3 vs 15.1 ?0.3 g/dL). Antiviral therapy for 12 w resulted in decreases in ALT activity (-60 ?10 U/L), platelets (-45 ?9/mm3), white blood cells (-2.8 ?0.4/mm3) and haptoglobin (-20 ?10 mg/dL), and an increase in retiulocytes (+1.4 ?0.4%): none of these effects was significantly changed by AO. RBC levels of MDA and GSH were not significantly altered by either antiviral therapy or AO. In addition, AO did not significantly ameliorate the fall in Hb levels produced by antiviral therapy after 2, 4 or 12 w of treatment. Use of recombinant erythropoietin was similar in both groups (17% vs 12%). Conclusion The authors conclude, "This regimen of AO treatment with vitamin E, vitamin C and S-adenosyl-L-methionine did not substantially ameliorate the fall in Hb levels in HCV patients during the first 12 w of therapy with pegylated interferon alfa-2b and ribavirin."Jackie

New Messenger with Voice. Call regular phones from your PC and save big.

[Guest guest]

Vegetable Oils are Natural Sources of Vitamin E ( wheatgerm is also a high source)

Many people argue that it is not necessary to take pills or capsules of vitamins because you can get your vitamins and much more from the foods you normally eat. It is hard to argue against the "natural is better" point of view. It is of course very difficult for those of us who are forced to eat on the run and have to eat only what we can hold in one hand to get our share of essential nutrients each day. Added to this is the fact that when studies show health benefits of such things as vitamins, it is often at intake levels beyond what is normally accepted as adequate for proper nutrition.

Vitamin E is a nutrient that is constantly in the news these days, mainly because of its antioxidant properties. The whole topic of vitamin E is complicated by the fact that there are eight chemically related compounds - called isomers - that are often lumped together and called vitamin E. d-alpha-tocopherol is the shorter and easier way of referring to [2R-2R*(4R*,8R*)]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1- benzopyran-6-0l or vitamin E. In many of the foods we eat we find alpha-tocopherol and in addition beta-tocopherol, delta-tocopherol, gamma-tocopherol and esters of alpha-tocoperol. All of these compounds have "vitamin E activity" in the classical sense, but are not as potent as alpha-tocopherol. However, as far as its antioxidant effectiveness goes, alpha-tocopherol is often not as good as the other forms of vitamin E. It is widely accepted that delta is a better antioxidant than gamma which is better than beta which is better than alpha.

So how can you increase your intake of vitamin E? Generally oilseeds (canola, soybean, corn, safflower and cottonseed ) and their products (vegetable oils or margarines) are good sources of vitamin E. But as the table below shows, vegetable oils contain a mixture of the different chemical forms of tocopherol.

TOCOPHEROL CONTENT OF VARIOUS VEGETABLE OILS (mg/kg)

Oil

alpha

beta

gamma

delta

Soybean

116

34

737

275

Sunflower

608

17

11

-

Olive

93

-

7.3

-

Canola

192

-

431

40

Most food labels are not detailed enough to report the different isomers of vitamin E and so the value quoted on the label is either for only alpha-tocopherol or it may be for the total of all vitamin E compounds. It depends on how the analyses were carried out. It is probably best to use a variety of oils in the diet to make sure that you are getting at least some of all the different forms of vitamin E. Vegetable oils still are one of the best sources of vitamin E in the diet.

Re: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in H

Liz, Jax, why is it that "real" vitamine E is so expensive? Don't we get Vit. E naturally eating fish? If I'm wrong here, where is a good source of Vit E that can be added to the diet?

Thanks in advance,

Love to all,

Chris

Eat well, sleep well, be well!Jackie on <redjaxjm@...> wrote:

Good article Liz,, but I have one comment,, and of course you knew I would have one comment,, lol,,

First off, IF you read the conclusion, it said it did not produce a significant effect against the anemia,, Natural substances wont give the same kind of effect that chemicals have , one should NOT EXPECT it to do the same as procrit.. but it doesnt have the side effects that procrit have either.. procrit didnt work very well for me, it managed to keep me from falling further ,, but did not raise my hemoglobin at all,, so I dont think that one would expect that AO's would cause a huge raise in hemo-g's or RBC's.. but might help maintain it from falling faster,, so the study is not accurate in what its expecting.. and Second,, I wonder IF they used REAL or synthetic vit E.. there is a huge difference and the body does NOT recognize synthetic E as E at all.. most studies use synthetic E because its so much cheaper than real E...

I WISH they would do a REAL study with REAL vitamin E,, and use all the different kinds of vit e... then they would have real answers..

love ya sis,

jaxelizabethnv1 <elizabethnv1@...> wrote:

Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in HCV Patients Treated with Pegylated Interferon Alfa-2b (Peg-Intron) and RibavirinRibavirin is commonly used in combination with pegylated interferon alfa to treat patients with chronic hepatitis C (HCV). Ribavirin can cause hemolysis and a decrease in hemoglobin (Hb) levels is common. The mechanism of ribavirin-induced hemolysis is uncertain, but an increased susceptibility of erythrocytes (RBC) to membrane oxidative damage may play a role. The aim of the present study was to test whether antioxidant (AO) treatment would ameliorate the fall in Hb levels in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) and ribavirin. A randomized, prospective, open-label study was designed to study the effects of AO treatment (vitamin E, 400 IU BID; vitamin C, 500 mg BID; S-adenosyl-L-methionine, 400 mg TID) in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) 1.5 mcg/kg QW) and ribavirin (800-1400 mg QD). Treatment-naive, non-smoking patients with chronic HCV were divided into two groups: the AO group (n=17) received AO for a total of 28 w beginning 4 w before antiviral therapy, while the control group (n=24) received antiviral therapy alone. This report focuses on measurements made at entry (6 w prior to antiviral therapy) and at 2, 4 or 12 w of antiviral therapy. RBC levels of malondialdehyde (MDA, a lipid peroxidation product) and glutathione (GSH) were also measured. Results The control and AO groups were well matched with respect to age (47 ?1 vs 49 ?2), gender (67% vs 59% male), race (83% vs 94% Caucasian), HCV genotype (79% vs 94% type 1), and baseline Hb levels (15.2 ?0.3 vs 15.1 ?0.3 g/dL). Antiviral therapy for 12 w resulted in decreases in ALT activity (-60 ?10 U/L), platelets (-45 ?9/mm3), white blood cells (-2.8 ?0.4/mm3) and haptoglobin (-20 ?10 mg/dL), and an increase in retiulocytes (+1.4 ?0.4%): none of these effects was significantly changed by AO. RBC levels of MDA and GSH were not significantly altered by either antiviral therapy or AO. In addition, AO did not significantly ameliorate the fall in Hb levels produced by antiviral therapy after 2, 4 or 12 w of treatment. Use of recombinant erythropoietin was similar in both groups (17% vs 12%). Conclusion The authors conclude, "This regimen of AO treatment with vitamin E, vitamin C and S-adenosyl-L-methionine did not substantially ameliorate the fall in Hb levels in HCV patients during the first 12 w of therapy with pegylated interferon alfa-2b and ribavirin."Jackie

New Messenger with Voice. Call regular phones from your PC and save big.

[Guest guest]

Great Article Liz,, yes good sources of REAL vit E are found in oils, nuts and seeds and wheatgerm.. I have a hard time with the excuses ppl give for NOT getting the right nutrition (being on the run and only being able to eat what you can hold in one hand while doing other things) really gets me.. I mean,, we ARE talking about our lives,, about our health here and I think anyone CAN get the right nutrition if they use a little bit of planning.. the synthetic vit E that is manufactured in the lab , the body doesnt even recognize it as E.. Im not sure what it thinks its is, but I have read articles that show that the body does NOT use it in the same way as 'Real vit E..elizabethnv1 <elizabethnv1@...> wrote: Vegetable Oils are Natural Sources

of Vitamin E ( wheatgerm is also a high source) Many people argue that it is not necessary to take pills or capsules of vitamins because you can get your vitamins and much more from the foods you normally eat. It is hard to argue against the "natural is better" point of view. It is of course very difficult for those of us who are forced to eat on the run and have to eat only what we can hold in one hand to get our share of essential nutrients each day. Added to this is the fact that when studies show health benefits of such things as vitamins, it is often at intake levels beyond what is normally accepted as adequate for proper nutrition. Vitamin E is a nutrient that is constantly in the news these days, mainly because of its antioxidant properties. The whole topic of vitamin E is complicated by the fact that there are eight chemically related compounds - called isomers - that are often lumped together and called vitamin E. d-alpha-tocopherol is the shorter

and easier way of referring to [2R-2R*(4R*,8R*)]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1- benzopyran-6-0l or vitamin E. In many of the foods we eat we find alpha-tocopherol and in addition beta-tocopherol, delta-tocopherol, gamma-tocopherol and esters of alpha-tocoperol. All of these compounds have "vitamin E activity" in the classical sense, but are not as potent as alpha-tocopherol. However, as far as its antioxidant effectiveness goes, alpha-tocopherol is often not as good as the other forms of vitamin E. It is widely accepted that delta is a better antioxidant than gamma which is better than beta which is better than alpha. So how can you increase your intake of vitamin E? Generally oilseeds (canola, soybean, corn, safflower and cottonseed ) and their products (vegetable oils or margarines) are good sources of vitamin E. But as the table below shows, vegetable oils contain a mixture of the different chemical forms of tocopherol. TOCOPHEROL CONTENT OF VARIOUS VEGETABLE OILS (mg/kg) Oil alpha beta gamma delta Soybean 116 34 737 275 Sunflower 608 17 11 - Olive 93 - 7.3 - Canola 192 - 431 40 Most food labels are not detailed enough to report the different isomers of vitamin E and so the value quoted on the label is either for only alpha-tocopherol or it may be for the total of all vitamin E compounds. It depends on how the analyses were carried out. It is probably best to use a

variety of oils in the diet to make sure that you are getting at least some of all the different forms of vitamin E. Vegetable oils still are one of the best sources of vitamin E in the diet. Re: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in H

Liz, Jax, why is it that "real" vitamine E is so expensive? Don't we get Vit. E naturally eating fish? If I'm wrong here, where is a good source of Vit E that can be added to the diet? Thanks in advance, Love to all, Eat well, sleep well, be well!Jackie on <redjaxjm@...> wrote: Good article Liz,, but I have one comment,, and of course you knew I would have one comment,, lol,, First off, IF you read the conclusion, it said it did not produce a significant effect against the anemia,, Natural substances wont give the same kind of effect that chemicals have , one should NOT EXPECT it to do the same as procrit.. but it doesnt have the side effects that procrit have either.. procrit

didnt work very well for me, it managed to keep me from falling further ,, but did not raise my hemoglobin at all,, so I dont think that one would expect that AO's would cause a huge raise in hemo-g's or RBC's.. but might help maintain it from falling faster,, so the study is not accurate in what its expecting.. and Second,, I wonder IF they used REAL or synthetic vit E.. there is a huge difference and the body does NOT recognize synthetic E as E at all.. most studies use synthetic E because its so much cheaper than real E... I WISH they would do a REAL study with REAL vitamin E,, and use all the different kinds of vit e... then they would have real answers.. love ya sis, jaxelizabethnv1 <elizabethnv1@...> wrote: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in HCV

Patients Treated with Pegylated Interferon Alfa-2b (Peg-Intron) and RibavirinRibavirin is commonly used in combination with pegylated interferon alfa to treat patients with chronic hepatitis C (HCV). Ribavirin can cause hemolysis and a decrease in hemoglobin (Hb) levels is common. The mechanism of ribavirin-induced hemolysis is uncertain, but an increased susceptibility of erythrocytes (RBC) to membrane oxidative damage may play a role. The aim of the present study was to test whether antioxidant (AO) treatment would ameliorate the fall in Hb levels in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) and ribavirin. A randomized, prospective, open-label study was designed to study the effects of AO treatment (vitamin E, 400 IU BID; vitamin C, 500 mg BID; S-adenosyl-L-methionine, 400 mg TID) in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) 1.5 mcg/kg QW) and ribavirin

(800-1400 mg QD). Treatment-naive, non-smoking patients with chronic HCV were divided into two groups: the AO group (n=17) received AO for a total of 28 w beginning 4 w before antiviral therapy, while the control group (n=24) received antiviral therapy alone. This report focuses on measurements made at entry (6 w prior to antiviral therapy) and at 2, 4 or 12 w of antiviral therapy. RBC levels of malondialdehyde (MDA, a lipid peroxidation product) and glutathione (GSH) were also measured. Results The control and AO groups were well matched with respect to age (47 ?1 vs 49 ?2), gender (67% vs 59% male), race (83% vs 94% Caucasian), HCV genotype (79% vs 94% type 1), and baseline Hb levels (15.2 ?0.3 vs 15.1 ?0.3 g/dL). Antiviral therapy for 12 w resulted in decreases in ALT activity (-60 ?10 U/L), platelets (-45 ?9/mm3), white blood cells (-2.8 ?0.4/mm3) and haptoglobin (-20 ?10 mg/dL), and an increase

in retiulocytes (+1.4 ?0.4%): none of these effects was significantly changed by AO. RBC levels of MDA and GSH were not significantly altered by either antiviral therapy or AO. In addition, AO did not significantly ameliorate the fall in Hb levels produced by antiviral therapy after 2, 4 or 12 w of treatment. Use of recombinant erythropoietin was similar in both groups (17% vs 12%). Conclusion The authors conclude, "This regimen of AO treatment with vitamin E, vitamin C and S-adenosyl-L-methionine did not substantially ameliorate the fall in Hb levels in HCV patients during the first 12 w of therapy with pegylated interferon alfa-2b and ribavirin."Jackie New Messenger with Voice. Call

regular phones from your PC and save big. Jackie

[Guest guest]

Nuts, seeds, wheatgerm, oils are all good sources of vit e,, why the synthetic is more expensive ,, heck I dunno, but I think that its cuz THEY CAN charge more,, and we are so indoctrinated to believe that 'anything' made by big pharmy is better and therefore should cost more,, just my 2 centsHunter <us2china2@...> wrote: Liz, Jax, why is it that "real" vitamine E is so expensive? Don't we get Vit. E naturally eating fish? If I'm wrong here, where is a good source of Vit E that can be added to the diet? Thanks in advance, Love to all, Eat well, sleep well, be well!Jackie on <redjaxjm@...> wrote: Good article Liz,, but I have one comment,, and of course you knew I would have one comment,, lol,, First off, IF you read the conclusion, it said it did not produce a significant effect against the anemia,, Natural substances wont give the same kind of effect that chemicals have , one should NOT EXPECT it to do the same as procrit.. but it doesnt have the side effects that procrit have either.. procrit didnt work very well for me, it managed to keep me from falling further ,, but did not raise my hemoglobin at all,, so I dont think that one would expect that AO's would cause a huge raise in hemo-g's or RBC's.. but might help maintain it from falling faster,, so the study is not accurate in what its expecting.. and Second,, I wonder IF they used REAL or synthetic vit E.. there is a huge difference and the body does NOT recognize synthetic E as E at all.. most studies use synthetic E because its so much cheaper than real E... I WISH

they would do a REAL study with REAL vitamin E,, and use all the different kinds of vit e... then they would have real answers.. love ya sis, jaxelizabethnv1 <elizabethnv1@...> wrote: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in HCV Patients Treated with Pegylated Interferon Alfa-2b (Peg-Intron) and RibavirinRibavirin is commonly used in combination with pegylated interferon alfa to treat patients with chronic hepatitis C (HCV). Ribavirin can cause hemolysis and a decrease in hemoglobin (Hb) levels is common. The mechanism of ribavirin-induced hemolysis is uncertain, but an increased susceptibility of erythrocytes (RBC) to membrane oxidative damage may play a role. The aim of the present study was to test whether antioxidant (AO)

treatment would ameliorate the fall in Hb levels in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) and ribavirin. A randomized, prospective, open-label study was designed to study the effects of AO treatment (vitamin E, 400 IU BID; vitamin C, 500 mg BID; S-adenosyl-L-methionine, 400 mg TID) in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) 1.5 mcg/kg QW) and ribavirin (800-1400 mg QD). Treatment-naive, non-smoking patients with chronic HCV were divided into two groups: the AO group (n=17) received AO for a total of 28 w beginning 4 w before antiviral therapy, while the control group (n=24) received antiviral therapy alone. This report focuses on measurements made at entry (6 w prior to antiviral therapy) and at 2, 4 or 12 w of antiviral therapy. RBC levels of malondialdehyde (MDA, a lipid peroxidation product) and glutathione (GSH) were also measured. Results

The control and AO groups were well matched with respect to age (47 ?1 vs 49 ?2), gender (67% vs 59% male), race (83% vs 94% Caucasian), HCV genotype (79% vs 94% type 1), and baseline Hb levels (15.2 ?0.3 vs 15.1 ?0.3 g/dL). Antiviral therapy for 12 w resulted in decreases in ALT activity (-60 ?10 U/L), platelets (-45 ?9/mm3), white blood cells (-2.8 ?0.4/mm3) and haptoglobin (-20 ?10 mg/dL), and an increase in retiulocytes (+1.4 ?0.4%): none of these effects was significantly changed by AO. RBC levels of MDA and GSH were not significantly altered by either antiviral therapy or AO. In addition, AO did not significantly ameliorate the fall in Hb levels produced by antiviral therapy after 2, 4 or 12 w of treatment. Use of recombinant erythropoietin was similar in both groups (17% vs 12%). Conclusion The authors conclude, "This regimen of AO treatment with vitamin E, vitamin C and

S-adenosyl-L-methionine did not substantially ameliorate the fall in Hb levels in HCV patients during the first 12 w of therapy with pegylated interferon alfa-2b and ribavirin."Jackie New Messenger with Voice. Call regular phones from your PC and save big. Jackie

[Guest guest]

Well its a good article hon,, elizabethnv1 <elizabethnv1@...> wrote: LOL yeah I expected you to find something to say about this ,hehe love ya girl Re: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in H Good article Liz,, but I have one comment,, and of course you knew I would have one comment,, lol,, First off, IF you read the conclusion, it said it did not produce a significant effect against the anemia,, Natural substances wont give the same kind of effect that chemicals have , one should NOT EXPECT it to do the same as procrit.. but it doesnt have the side effects that procrit have either.. procrit didnt work very well for me, it managed to keep me from falling further ,, but did not raise my hemoglobin at all,, so I dont think that one would expect that AO's would cause a huge raise in hemo-g's or RBC's.. but might help maintain it from falling faster,, so the study is not accurate in what its expecting.. and

Second,, I wonder IF they used REAL or synthetic vit E.. there is a huge difference and the body does NOT recognize synthetic E as E at all.. most studies use synthetic E because its so much cheaper than real E... I WISH they would do a REAL study with REAL vitamin E,, and use all the different kinds of vit e... then they would have real answers.. love ya sis, jaxelizabethnv1 <elizabethnv1@...> wrote: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in HCV Patients Treated with Pegylated Interferon Alfa-2b (Peg-Intron) and RibavirinRibavirin is commonly used in combination with pegylated interferon alfa to treat patients with chronic hepatitis C (HCV). Ribavirin can cause hemolysis and a decrease in hemoglobin (Hb) levels is common. The

mechanism of ribavirin-induced hemolysis is uncertain, but an increased susceptibility of erythrocytes (RBC) to membrane oxidative damage may play a role. The aim of the present study was to test whether antioxidant (AO) treatment would ameliorate the fall in Hb levels in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) and ribavirin. A randomized, prospective, open-label study was designed to study the effects of AO treatment (vitamin E, 400 IU BID; vitamin C, 500 mg BID; S-adenosyl-L-methionine, 400 mg TID) in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) 1.5 mcg/kg QW) and ribavirin (800-1400 mg QD). Treatment-naive, non-smoking patients with chronic HCV were divided into two groups: the AO group (n=17) received AO for a total of 28 w beginning 4 w before antiviral therapy, while the control group (n=24) received antiviral therapy alone. This report focuses on

measurements made at entry (6 w prior to antiviral therapy) and at 2, 4 or 12 w of antiviral therapy. RBC levels of malondialdehyde (MDA, a lipid peroxidation product) and glutathione (GSH) were also measured. Results The control and AO groups were well matched with respect to age (47 ± 1 vs 49 ± 2), gender (67% vs 59% male), race (83% vs 94% Caucasian), HCV genotype (79% vs 94% type 1), and baseline Hb levels (15.2 ± 0.3 vs 15.1 ± 0.3 g/dL). Antiviral therapy for 12 w resulted in decreases in ALT activity (-60 ± 10 U/L), platelets (-45 ± 9/mm3), white blood cells (-2.8 ± 0.4/mm3) and haptoglobin (-20 ± 10 mg/dL), and an increase in retiulocytes (+1.4 ± 0.4%): none of these effects was significantly changed by AO. RBC levels of MDA and GSH were not significantly altered by either antiviral therapy or AO. In addition, AO did not significantly ameliorate the fall in Hb levels produced by antiviral therapy

after 2, 4 or 12 w of treatment. Use of recombinant erythropoietin was similar in both groups (17% vs 12%). Conclusion The authors conclude, "This regimen of AO treatment with vitamin E, vitamin C and S-adenosyl-L-methionine did not substantially ameliorate the fall in Hb levels in HCV patients during the first 12 w of therapy with pegylated interferon alfa-2b and ribavirin."Jackie Jackie

[Guest guest]

Tofu (or in Chinese Doufu [pronounced like dough fu]) ROCKS! I eat gobs of this stuff everyday. And I'm going to switch from olive oil for cooking to soy oil too. According to the chart, soy far outclasses all the others. Could be why the Chinese have a lower incidence of cancers than Americans. Incidently ladies, The women here know doufu is helpful for premenstral and menapausal problems, and believe it is very good for the skin. I saw a special on soy beans once that touted them as the worlds perfect food. but then I heard the same thing about eggs when I was younger... some of everything is probably the best you can do.elizabethnv1 <elizabethnv1@...> wrote: Vegetable Oils are

Natural Sources of Vitamin E ( wheatgerm is also a high source) Many people argue that it is not necessary to take pills or capsules of vitamins because you can get your vitamins and much more from the foods you normally eat. It is hard to argue against the "natural is better" point of view. It is of course very difficult for those of us who are forced to eat on the run and have to eat only what we can hold in one hand to get our share of essential nutrients each day. Added to this is the fact that when studies show health benefits of such things as vitamins, it is often at intake levels beyond what is normally accepted as adequate for proper nutrition. Vitamin E is a nutrient that is constantly in the news these days, mainly because of its antioxidant properties. The whole topic of vitamin E is complicated by the fact that there are eight chemically related compounds - called isomers - that are often lumped together and called vitamin E. d-alpha-tocopherol

is the shorter and easier way of referring to [2R-2R*(4R*,8R*)]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1- benzopyran-6-0l or vitamin E. In many of the foods we eat we find alpha-tocopherol and in addition beta-tocopherol, delta-tocopherol, gamma-tocopherol and esters of alpha-tocoperol. All of these compounds have "vitamin E activity" in the classical sense, but are not as potent as alpha-tocopherol. However, as far as its antioxidant effectiveness goes, alpha-tocopherol is often not as good as the other forms of vitamin E. It is widely accepted that delta is a better antioxidant than gamma which is better than beta which is better than alpha. So how can you increase your intake of vitamin E? Generally oilseeds (canola, soybean, corn, safflower and cottonseed ) and their products (vegetable oils or margarines) are good sources of vitamin E. But as the table below shows, vegetable oils contain a mixture of the different chemical forms of

tocopherol. TOCOPHEROL CONTENT OF VARIOUS VEGETABLE OILS (mg/kg) Oil alpha beta gamma delta Soybean 116 34 737 275 Sunflower 608 17 11 - Olive 93 - 7.3 - Canola 192 - 431 40 Most food labels are not detailed enough to report the different isomers of vitamin E and so the value quoted on the label is either for only alpha-tocopherol or it may be for the total of all vitamin E compounds. It depends on how the analyses were carried out. It is

probably best to use a variety of oils in the diet to make sure that you are getting at least some of all the different forms of vitamin E. Vegetable oils still are one of the best sources of vitamin E in the diet. Re: Antioxidant Treatment Does Not Substantially Counter the Fall

in Hemoglobin in H Liz, Jax, why is it that "real" vitamine E is so expensive? Don't we get Vit. E naturally eating fish? If I'm wrong here, where is a good source of Vit E that can be added to the diet? Thanks in advance, Love to all, Eat well, sleep well, be well!Jackie on <redjaxjm@...> wrote: Good article Liz,, but I have one comment,, and of course you knew I would have one comment,, lol,, First off, IF you read the conclusion, it said it did not produce a significant effect against the anemia,, Natural substances wont give the same kind of effect that chemicals have , one should NOT EXPECT it to do the same as procrit.. but it doesnt have the side effects that

procrit have either.. procrit didnt work very well for me, it managed to keep me from falling further ,, but did not raise my hemoglobin at all,, so I dont think that one would expect that AO's would cause a huge raise in hemo-g's or RBC's.. but might help maintain it from falling faster,, so the study is not accurate in what its expecting.. and Second,, I wonder IF they used REAL or synthetic vit E.. there is a huge difference and the body does NOT recognize synthetic E as E at all.. most studies use synthetic E because its so much cheaper than real E... I WISH they would do a REAL study with REAL vitamin E,, and use all the different kinds of vit e... then they would have real answers.. love ya sis, jaxelizabethnv1 <elizabethnv1@...> wrote: Antioxidant Treatment Does Not Substantially Counter the

Fall in Hemoglobin in HCV Patients Treated with Pegylated Interferon Alfa-2b (Peg-Intron) and RibavirinRibavirin is commonly used in combination with pegylated interferon alfa to treat patients with chronic hepatitis C (HCV). Ribavirin can cause hemolysis and a decrease in hemoglobin (Hb) levels is common. The mechanism of ribavirin-induced hemolysis is uncertain, but an increased susceptibility of erythrocytes (RBC) to membrane oxidative damage may play a role. The aim of the present study was to test whether antioxidant (AO) treatment would ameliorate the fall in Hb levels in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) and ribavirin. A randomized, prospective, open-label study was designed to study the effects of AO treatment (vitamin E, 400 IU BID; vitamin C, 500 mg BID; S-adenosyl-L-methionine, 400 mg TID) in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) 1.5

mcg/kg QW) and ribavirin (800-1400 mg QD). Treatment-naive, non-smoking patients with chronic HCV were divided into two groups: the AO group (n=17) received AO for a total of 28 w beginning 4 w before antiviral therapy, while the control group (n=24) received antiviral therapy alone. This report focuses on measurements made at entry (6 w prior to antiviral therapy) and at 2, 4 or 12 w of antiviral therapy. RBC levels of malondialdehyde (MDA, a lipid peroxidation product) and glutathione (GSH) were also measured. Results The control and AO groups were well matched with respect to age (47 ?1 vs 49 ?2), gender (67% vs 59% male), race (83% vs 94% Caucasian), HCV genotype (79% vs 94% type 1), and baseline Hb levels (15.2 ?0.3 vs 15.1 ?0.3 g/dL). Antiviral therapy for 12 w resulted in decreases in ALT activity (-60 ?10 U/L), platelets (-45 ?9/mm3), white blood cells (-2.8 ?0.4/mm3) and haptoglobin (-20

?10 mg/dL), and an increase in retiulocytes (+1.4 ?0.4%): none of these effects was significantly changed by AO. RBC levels of MDA and GSH were not significantly altered by either antiviral therapy or AO. In addition, AO did not significantly ameliorate the fall in Hb levels produced by antiviral therapy after 2, 4 or 12 w of treatment. Use of recombinant erythropoietin was similar in both groups (17% vs 12%). Conclusion The authors conclude, "This regimen of AO treatment with vitamin E, vitamin C and S-adenosyl-L-methionine did not substantially ameliorate the fall in Hb levels in HCV patients during the first 12 w of therapy with pegylated interferon alfa-2b and ribavirin."Jackie New Messenger with Voice. Call regular phones from your PC and save big.

Messenger with Voice. PC-to-Phone calls for ridiculously low rates.

[Guest guest]

, just be careful,, remember BALANCE ,,, if you consume too much soy,, it raises the hormone levels in your body and if you have an occult hormone driven tumor,, it can spring it into action... just a thought hon,, Olive oil is a great choice of oil,, Hunter <us2china2@...> wrote: Tofu (or in Chinese Doufu [pronounced like dough fu]) ROCKS! I eat gobs of this stuff everyday. And I'm going to switch from olive oil for cooking to soy oil too. According to the chart, soy far outclasses all the others. Could be why the Chinese have a lower incidence of cancers than Americans. Incidently ladies, The women here know doufu is helpful for premenstral and menapausal problems, and believe it is very good for the skin. I saw a special on soy beans once that touted them as the worlds perfect

food. but then I heard the same thing about eggs when I was younger... some of everything is probably the best you can do.elizabethnv1 <elizabethnv1@...> wrote: Vegetable Oils are Natural Sources of Vitamin E ( wheatgerm is also a high source) Many people argue that it is not necessary to take pills or capsules of vitamins because you can get your vitamins and much more from the foods you normally eat. It is hard to argue against the "natural is better" point of view. It is of course very difficult for those of us who are forced to eat on the run and have to eat only what we can hold in one hand to get our share of essential nutrients each day. Added to this is the fact that when studies show health benefits of

such things as vitamins, it is often at intake levels beyond what is normally accepted as adequate for proper nutrition. Vitamin E is a nutrient that is constantly in the news these days, mainly because of its antioxidant properties. The whole topic of vitamin E is complicated by the fact that there are eight chemically related compounds - called isomers - that are often lumped together and called vitamin E. d-alpha-tocopherol is the shorter and easier way of referring to [2R-2R*(4R*,8R*)]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1- benzopyran-6-0l or vitamin E. In many of the foods we eat we find alpha-tocopherol and in addition beta-tocopherol, delta-tocopherol, gamma-tocopherol and esters of alpha-tocoperol. All of these compounds have "vitamin E activity" in the classical sense, but are not as potent as alpha-tocopherol. However, as far as its antioxidant effectiveness goes, alpha-tocopherol is often not as good as the other forms of vitamin E.

It is widely accepted that delta is a better antioxidant than gamma which is better than beta which is better than alpha. So how can you increase your intake of vitamin E? Generally oilseeds (canola, soybean, corn, safflower and cottonseed ) and their products (vegetable oils or margarines) are good sources of vitamin E. But as the table below shows, vegetable oils contain a mixture of the different chemical forms of tocopherol. TOCOPHEROL CONTENT OF VARIOUS VEGETABLE OILS (mg/kg) Oil alpha beta gamma delta Soybean 116 34 737 275 Sunflower 608 17 11 - Olive 93 - 7.3 - Canola 192 - 431 40 Most food labels are not detailed enough to report the different isomers of vitamin E and so the value quoted on the label is either for only alpha-tocopherol or it may be for the total of all vitamin E compounds. It depends on how the analyses were carried out. It is probably best to use a variety of oils in the diet to make sure that you are getting at least some of all the different forms of vitamin E. Vegetable oils still are one of the best sources of vitamin E in the diet. Re: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in H Liz, Jax, why is it that "real" vitamine E is so expensive? Don't we get Vit. E naturally eating fish? If I'm wrong here, where is a good source of Vit E that can be added to the diet? Thanks in advance, Love to all, Eat well, sleep well, be well!Jackie on <redjaxjm@...> wrote: Good article Liz,, but I have one comment,, and of course you knew I would have one comment,, lol,, First off, IF you read the conclusion, it said it did not produce a significant effect against the anemia,, Natural substances wont give the same kind of effect that chemicals have , one should NOT EXPECT it to do the same as procrit.. but it doesnt have the side effects that procrit have either.. procrit didnt work very well for me, it managed to keep me from falling further ,, but did not raise my hemoglobin at all,, so I dont think that one would expect that AO's would cause a huge raise in hemo-g's or RBC's.. but might help maintain it from falling faster,, so the study is not accurate in what its expecting.. and Second,, I wonder IF they used REAL or synthetic vit E.. there is a huge difference and the body does NOT recognize synthetic E as E at all.. most studies use synthetic E because its so much

cheaper than real E... I WISH they would do a REAL study with REAL vitamin E,, and use all the different kinds of vit e... then they would have real answers.. love ya sis, jaxelizabethnv1 <elizabethnv1@...> wrote: Antioxidant Treatment Does Not Substantially Counter the Fall in Hemoglobin in HCV Patients Treated with Pegylated Interferon Alfa-2b (Peg-Intron) and RibavirinRibavirin is commonly used in combination with pegylated interferon alfa to treat patients with chronic hepatitis C (HCV). Ribavirin can cause hemolysis and a decrease in hemoglobin (Hb) levels is common. The mechanism of ribavirin-induced hemolysis is uncertain, but an increased susceptibility of erythrocytes (RBC) to membrane oxidative damage may play a role. The aim of the present study

was to test whether antioxidant (AO) treatment would ameliorate the fall in Hb levels in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) and ribavirin. A randomized, prospective, open-label study was designed to study the effects of AO treatment (vitamin E, 400 IU BID; vitamin C, 500 mg BID; S-adenosyl-L-methionine, 400 mg TID) in HCV patients treated with pegylated interferon alfa-2b (Peg-Intron) 1.5 mcg/kg QW) and ribavirin (800-1400 mg QD). Treatment-naive, non-smoking patients with chronic HCV were divided into two groups: the AO group (n=17) received AO for a total of 28 w beginning 4 w before antiviral therapy, while the control group (n=24) received antiviral therapy alone. This report focuses on measurements made at entry (6 w prior to antiviral therapy) and at 2, 4 or 12 w of antiviral therapy. RBC levels of malondialdehyde (MDA, a lipid peroxidation product) and glutathione (GSH)

were also measured. Results The control and AO groups were well matched with respect to age (47 ?1 vs 49 ?2), gender (67% vs 59% male), race (83% vs 94% Caucasian), HCV genotype (79% vs 94% type 1), and baseline Hb levels (15.2 ?0.3 vs 15.1 ?0.3 g/dL). Antiviral therapy for 12 w resulted in decreases in ALT activity (-60 ?10 U/L), platelets (-45 ?9/mm3), white blood cells (-2.8 ?0.4/mm3) and haptoglobin (-20 ?10 mg/dL), and an increase in retiulocytes (+1.4 ?0.4%): none of these effects was significantly changed by AO. RBC levels of MDA and GSH were not significantly altered by either antiviral therapy or AO. In addition, AO did not significantly ameliorate the fall in Hb levels produced by antiviral therapy after 2, 4 or 12 w of treatment. Use of recombinant erythropoietin was similar in both groups (17% vs 12%). Conclusion The authors conclude, "This regimen of AO treatment with

vitamin E, vitamin C and S-adenosyl-L-methionine did not substantially ameliorate the fall in Hb levels in HCV patients during the first 12 w of therapy with pegylated interferon alfa-2b and ribavirin."Jackie New Messenger with Voice. Call regular phones from your PC and save big. Messenger with Voice. PC-to-Phone calls for ridiculously low rates. Jackie