Re: [SPAM?] Autism May Result From Slight Changes in Brain Genes

[Guest guest]

Here's a thought:

If I had a name like Sanofi-Pasteur (note the emphasis on Pasteur), and I was putting thimerosal into vaccines at the levels they're putting into vaccines:

http://www.vaccinesafety.edu/thi-table.htm

then why wouldn't my company use a Medical Institute of at least partial same name (Pasteur), to rationalize the poisons they inject into babies by blaming it on the babies and finding genes to fit the circumstance?

You see, it's not the poisons that poison the baby, it's the baby's genes.

This is beyond Hail .

The level that once great institutes must now resort to in order to deal with collapsing credibiliyand lies is at least a great societal tragedy.

Worse, our media is complicit.

[sPAM?] Autism May Result From Slight Changes in Brain Genes

Study: Autism May Result From Slight Changes in Brain GenesMonday, December 18, 2006By J. DeNoonhttp://www.foxnews.com/story/0,2933,237290,00.htmlAutism disorders result from slight changes in genes that govern brain structure, suggests a study from France's Pasteur Institute.Autism and related diseases, broadly known as autism spectrum disorders, are among the most genetic of all psychiatric and neurological problems. Genetic changes are thought to be present in 3 percent to 6 percent of all cases.What Raises a Baby's Risk of Autism?What kinds of changes are important? It looks like even small changes -- resulting in either too much or too little gene function -- affect how well people can use language and how well they can interact with others.There's no single autism gene. However, changes in a certain region of one human chromosome are often seen in people with autism spectrum disorders.SHANK3 is the name of one of the three genes in this part of the chromosome.Researchers Bourgeron, PhD, and colleagues at the Pasteur Institute in Paris painstakingly evaluated the SHANK3 gene in more than 200 people with autism spectrum disorders. They found the gene in three families.

[Guest guest]

Also, there could be some sort of epigenetic control mechanism affecting the expression of the SHANK3 gene. Please see below: http://72.14.203.104/search?q=cache:5VpZtyo2nZsJ:fens2006.neurosciences.asso.fr/abstracts/R7/A231_7.html+shank3+epigenetic & hl=en & gl=ca & ct=clnk & cd=1 http://fens2006.neurosciences.asso.fr/abstracts/R7/A231_7.html An excerpt from the above: "All together, these data suggest the existence of an epigenetic control mechanism regulating SHANK3, but not SHANK1 and SHANK2, expression. Aasa H

<stratpat@...> wrote: Here's a thought: If I had a name like Sanofi-Pasteur (note the emphasis on Pasteur), and I was putting thimerosal into vaccines at the levels they're putting into vaccines: http://www.vaccinesafety.edu/thi-table.htm then why wouldn't my company use a Medical Institute of at least partial same name (Pasteur), to rationalize the poisons they inject into babies by blaming it on the babies and finding genes to fit the circumstance? You see, it's not the poisons that poison the baby, it's the baby's genes. This is beyond Hail . The level that once great institutes must now resort to in order to deal with collapsing

credibiliyand lies is at least a great societal tragedy. Worse, our media is complicit. [sPAM?]

Autism May Result From Slight Changes in Brain Genes Study: Autism May Result From Slight Changes in Brain GenesMonday, December 18, 2006By J. DeNoonhttp://www.foxnews.com/story/0,2933,237290,00.htmlAutism disorders result from slight changes in genes that govern brain structure, suggests a study from France's Pasteur Institute.Autism and related diseases, broadly known as autism spectrum disorders, are among the most genetic of all psychiatric and neurological problems. Genetic changes are thought to be present in 3 percent to 6 percent of all cases.What Raises a Baby's Risk of Autism?What kinds of changes are important? It looks like even small changes -- resulting in either too much

or too little gene function -- affect how well people can use language and how well they can interact with others.There's no single autism gene. However, changes in a certain region of one human chromosome are often seen in people with autism spectrum disorders.SHANK3 is the name of one of the three genes in this part of the chromosome.Researchers Bourgeron, PhD, and colleagues at the Pasteur Institute in Paris painstakingly evaluated the SHANK3 gene in more than 200 people with autism spectrum disorders. They found the gene in three families.

[Guest guest]

Absolutely. Methylation reactions key in some of our kids (MB12/DMG effect, etc). But the fact that Pasteur institute does genetic work on autistic children when Sanofi Pasteur still uses thimerosal in its vaccines (one of the few vaccine manufacturers still using full compliment of thimerosal in its vaccines) smacks of such a huge potential conflict of interest that even if the work is top notch, it has a tremendous burden of proof surrounding it that it may never get past. Kind of like the IOM report on what is now beginning to become more widely known as flawed CDC epidemiology.

http://www.sanofipasteur.us/sanofi-pasteur-us/front/templates/index.jsp?codeRubrique=47 & lang=EN

[sPAM?] Autism May Result From Slight Changes in Brain Genes

Study: Autism May Result From Slight Changes in Brain GenesMonday, December 18, 2006By J. DeNoonhttp://www.foxnews.com/story/0,2933,237290,00.htmlAutism disorders result from slight changes in genes that govern brain structure, suggests a study from France's Pasteur Institute.Autism and related diseases, broadly known as autism spectrum disorders, are among the most genetic of all psychiatric and neurological problems. Genetic changes are thought to be present in 3 percent to 6 percent of all cases.What Raises a Baby's Risk of Autism?What kinds of changes are important? It looks like even small changes -- resulting in either too much or too little gene function -- affect how well people can use language and how well they can interact with others.There's no single autism gene. However, changes in a certain region of one human chromosome are often seen in people with autism spectrum disorders.SHANK3 is the name of one of the three genes in this part of the chromosome.Researchers Bourgeron, PhD, and colleagues at the Pasteur Institute in Paris painstakingly evaluated the SHANK3 gene in more than 200 people with autism spectrum disorders. They found the gene in three families.

[Guest guest]

The slight brain changes cited in this report has been hyped by the

researchers in media reports. They found the SHANK3 gene mutation in 3

out of 200 families they studied. What happened in the other 197.

I think we need to stand up and shout " BS " to these reports and to the

hype coming from the researchers. Is this an interesting finding that

requires examination, yes. Does it mean that autism is genetic. No, all

disease has some genetic basis. Some people don't catch colds, some

can't avoid them. Is susceptibility to rhinovirus or adenoviruses

genetic? I suspect no more nor less that autism is 'genetic. "

On Dec 19, 2006, at 12:48 PM, H wrote:

> Absolutely.  Methylation reactions key in some of our kids (MB12/DMG

> effect, etc).  But the fact that Pasteur institute does genetic work

> on autistic children when Sanofi Pasteur still uses thimerosal in its

> vaccines (one of the few vaccine manufacturers still using full

> compliment of thimerosal in its vaccines) smacks of such a huge

> potential conflict of interest that even if the work is top notch, it

> has a tremendous burden of proof surrounding it that it may never get

> past.  Kind of like the IOM report on what is now beginning to become

> more widely known as flawed CDC epidemiology. 

>  

> http://www.sanofipasteur.us/sanofi-pasteur-us/front/templates/

> index.jsp?codeRubrique=47 & lang=EN

>  

>  

>> [sPAM?] Autism May Result From Slight Changes in

>>>> Brain Genes

>>>>

>>>> Study: Autism May Result From Slight Changes in Brain Genes

>>>> Monday, December 18, 2006

>>>>

>>>> By J. DeNoon

>>>> http://www.foxnews.com/story/0,2933,237290,00.html

>>>>

>>>>

>>>> Autism disorders result from slight changes in genes that govern

>>>> brain structure, suggests a study from France's Pasteur Institute.

>>>>

>>>> Autism and related diseases, broadly known as autism spectrum

>>>> disorders, are among the most genetic of all psychiatric and

>>>> neurological problems. Genetic changes are thought to be present in

>>>> 3 percent to 6 percent of all cases.

>>>>

>>>> What Raises a Baby's Risk of Autism?

>>>>

>>>>

>>>> What kinds of changes are important? It looks like even small

>>>> changes -- resulting in either too much or too little gene function

>>>> -- affect how well people can use language and how well they can

>>>> interact with others.

>>>>

>>>> There's no single autism gene. However, changes in a certain region

>>>> of one human chromosome are often seen in people with autism

>>>> spectrum disorders.

>>>>

>>>> SHANK3 is the name of one of the three genes in this part of the

>>>> chromosome.

>>>>

>>>> Researchers Bourgeron, PhD, and colleagues at the Pasteur

>>>> Institute in Paris painstakingly evaluated the SHANK3 gene in more

>>>> than 200 people with autism spectrum disorders. They found the gene

>>>> in three families.

>>

>

J. Krakow

Attorney At Law

2001 Marcus Avenue, Suite N125

Lake Success, New York 11042

(516) 354-3300

(646) 349-1771 (fax)

(212) 227-0600 (NYC telephone)

[Guest guest]

What if they find (beyond their doubt) a gene regulating mercury is

absent/switched off/changed in those with autism? Seems they have 2

courses, they can either expose and tout it as a genetic cause for

autism, clearing their liability, or they do everything they can to

keep it from surfacing.

Debi

>

> Absolutely. Methylation reactions key in some of our kids (MB12/DMG

effect, etc). But the fact that Pasteur institute does genetic work

on autistic children when Sanofi Pasteur still uses thimerosal in its

vaccines (one of the few vaccine manufacturers still using full

compliment of thimerosal in its vaccines) smacks of such a huge

potential conflict of interest that even if the work is top notch, it

has a tremendous burden of proof surrounding it that it may never get

past. Kind of like the IOM report on what is now beginning to become

more widely known as flawed CDC epidemiology.

>

>

http://www.sanofipasteur.us/sanofi-pasteur-us/front/templates/index.jsp?codeRubr\

ique=47 & lang=EN

[Guest guest]

Even if a gene " regulating mercury " is switched off genetics would not

be the cause -- mercury would be a substantial causal factors. In fact,

the MTHFR polymorphism (methylene tetrahydrofolate reductase) has been

shown to be possibly that kind of gene in that it results in reduced

folate metabolic activity and reduced methylation. This in turn results

in reduction in sulfation capability - i.e. lower levels of glutathione

and metallothionien, and a reduced ability to detoxify many substances

including mercury.

Perhaps 30% of the population has the MTHFR polymorphism (not mutation)

but absent toxic exposure, like mercury exposure, which is not normal,

30% of the population would not get sick. Parents of children with

MTHFR are usually not sick as they did not receive the current vaccine

schedule containing excess mercury.

MTHFR is one of a number of susceptibility genes that have been

identified. The idea of susceptibility is being distorted into one of

genetic cause. Susceptibility is not the same as causal.

On Dec 19, 2006, at 4:46 PM, Debi wrote:

> What if they find (beyond their doubt) a gene regulating mercury is

> absent/switched off/changed in those with autism? Seems they have 2

> courses, they can either expose and tout it as a genetic cause for

> autism, clearing their liability, or they do everything they can to

> keep it from surfacing.

>

> Debi

>

>

> >

> > Absolutely. Methylation reactions key in some of our kids (MB12/DMG

> effect, etc). But the fact that Pasteur institute does genetic work

> on autistic children when Sanofi Pasteur still uses thimerosal in its

> vaccines (one of the few vaccine manufacturers still using full

> compliment of thimerosal in its vaccines) smacks of such a huge

> potential conflict of interest that even if the work is top notch, it

> has a tremendous burden of proof surrounding it that it may never get

> past. Kind of like the IOM report on what is now beginning to become

> more widely known as flawed CDC epidemiology.

> >

> >

> http://www.sanofipasteur.us/sanofi-pasteur-us/front/templates/

> index.jsp?codeRubrique=47 & lang=EN

>

>

J. Krakow

Attorney At Law

2001 Marcus Avenue, Suite N125

Lake Success, New York 11042

(516) 354-3300

(646) 349-1771 (fax)

(212) 227-0600 (NYC telephone)

[Guest guest]

If the first, and there is a gene/genes to regulate mercury (there clearly is through variants and isozymes of glutathione synthetase and/or metallothionein, others), then why did they pump such toxic levels of mercury into babies? That's reckless on its face and will point to the fact that it's the mercury which caused the damage. They won't ever admit that.

If the second, that'll be the same old, same old. That is what to expect.

Re: [sPAM?] Autism May Result From Slight Changes in Brain Genes

What if they find (beyond their doubt) a gene regulating mercury isabsent/switched off/changed in those with autism? Seems they have 2courses, they can either expose and tout it as a genetic cause forautism, clearing their liability, or they do everything they can tokeep it from surfacing.Debi>> Absolutely. Methylation reactions key in some of our kids (MB12/DMGeffect, etc). But the fact that Pasteur institute does genetic workon autistic children when Sanofi Pasteur still uses thimerosal in itsvaccines (one of the few vaccine manufacturers still using fullcompliment of thimerosal in its vaccines) smacks of such a hugepotential conflict of interest that even if the work is top notch, ithas a tremendous burden of proof surrounding it that it may never getpast. Kind of like the IOM report on what is now beginning to becomemore widely known as flawed CDC epidemiology. > >http://www.sanofipasteur.us/sanofi-pasteur-us/front/templates/index.jsp?codeRubrique=47 & lang=EN

[Guest guest]



Shank3- I thought that's how Phil Mikelson lost the most recent US Open.

[sPAM?] Autism May Result From Slight Changes in Brain GenesStudy: Autism May Result From Slight Changes in Brain GenesMonday, December 18, 2006By J. DeNoonhttp://www.foxnews.com/story/0,2933,237290,00.htmlAutism disorders result from slight changes in genes that govern brain structure, suggests a study from France's Pasteur Institute.Autism and related diseases, broadly known as autism spectrum disorders, are among the most genetic of all psychiatric and neurological problems. Genetic changes are thought to be present in 3 percent to 6 percent of all cases.What Raises a Baby's Risk of Autism?What kinds of changes are important? It looks like even small changes -- resulting in either too much or too little gene function -- affect how well people can use language and how well they can interact with others.There's no single autism gene. However, changes in a certain region of one human chromosome are often seen in people with autism spectrum disorders.SHANK3 is the name of one of the three genes in this part of the chromosome.Researchers Bourgeron, PhD, and colleagues at the Pasteur Institute in Paris painstakingly evaluated the SHANK3 gene in more than 200 people with autism spectrum disorders. They found the gene in three families. J. KrakowAttorney At Law2001 Marcus Avenue, Suite N125Lake Success, New York 11042(516) 354-3300 (646) 349-1771 (fax)(212) 227-0600 (NYC telephone)

[Guest guest]



Virtually every drug exhibits side effects in a population because of a genetic subpopulation being exposed to a molecule in a different way- it may be the result of variation in the structure of receptors, numbers of receptors and where they are found, how quickly and to what metabolites a drug may be metabolized, etc. It always exists to some extent. Always. I don't know of a drug that does not show some side effect in someone.

The question is not whether there is genetic variation in a population, but how the variation manifests itself and whether care was taken to make sure the protocol/dosage regimen accommodated the existing variation to minimize the damage.

Re: [sPAM?] Autism May Result From Slight Changes in Brain Genes

Even if a gene "regulating mercury" is switched off genetics would not be the cause -- mercury would be a substantial causal factors. In fact, the MTHFR polymorphism (methylene tetrahydrofolate reductase) has been shown to be possibly that kind of gene in that it results in reduced folate metabolic activity and reduced methylation. This in turn results in reduction in sulfation capability - i.e. lower levels of glutathione and metallothionien, and a reduced ability to detoxify many substances including mercury.Perhaps 30% of the population has the MTHFR polymorphism (not mutation) but absent toxic exposure, like mercury exposure, which is not normal, 30% of the population would not get sick. Parents of children with MTHFR are usually not sick as they did not receive the current vaccine schedule containing excess mercury.MTHFR is one of a number of susceptibility genes that have been identified. The idea of susceptibility is being distorted into one of genetic cause. Susceptibility is not the same as causal.On Dec 19, 2006, at 4:46 PM, Debi wrote:

What if they find (beyond their doubt) a gene regulating mercury isabsent/switched off/changed in those with autism? Seems they have 2courses, they can either expose and tout it as a genetic cause forautism, clearing their liability, or they do everything they can tokeep it from surfacing.Debi>> Absolutely. Methylation reactions key in some of our kids (MB12/DMGeffect, etc). But the fact that Pasteur institute does genetic workon autistic children when Sanofi Pasteur still uses thimerosal in itsvaccines (one of the few vaccine manufacturers still using fullcompliment of thimerosal in its vaccines) smacks of such a hugepotential conflict of interest that even if the work is top notch, ithas a tremendous burden of proof surrounding it that it may never getpast. Kind of like the IOM report on what is now beginning to becomemore widely known as flawed CDC epidemiology. > >http://www.sanofipasteur.us/sanofi-pasteur-us/front/templates/index.jsp?codeRubrique=47 & lang=EN J. KrakowAttorney At Law2001 Marcus Avenue, Suite N125Lake Success, New York 11042(516) 354-3300 (646) 349-1771 (fax)(212) 227-0600 (NYC telephone)