Re: AntiPhospholipid Syndrome/Autism/Prevalence Statistics

[Guest guest]

Reading this email has prompted me to remember that when I bled at 31 weeks with Luke and was rushed into hospital - I am sure I was given an injection to stabilise things.

I cannot recall what injection it was? Has anyone experienced something similar?

I wonder if this had thermisol in it? I am going to try and find out.

Nicola

AntiPhospholipid Syndrome/Autism/Prevalence Statistics

I have just received an interesting phone call from a Specialist who treated me at St s Paddington, for Recurrent Miscarriage (3 prior to the birth of my autistic son) and one miscarriage in between the births of each of my neurotypical sons.

A few years ago I asked her about the possibility of a link between Antiphospholipid Syndrome (APS) which is a blood clotting problem which causes recurrent miscarriages, and Autism. This was to some extent based on my hunch that it is too much of a coincidence that the mothers of autistic children are often (but not always – which is why this puzzle is so complicated)

either :

-Rhesus Negative

-Recurrent Miscarriers (and have therefore had Anti-D or Rhogam injections probably containing Thiomersal)

-People with unexplained sub fertility

-People with explained sub fertility

-People who have a family history of auto immune disorders

-People with a family history of immune problems eg allergies etc

-People with problems processing heavy metals

or all or any of the above (and those with none at all)

Long story short, my Specialist said that she has in fact seen what appears to be quite a few more autistic babies born out of her clinics over the past few years. She was concerned that there are no accurate prevalence studies of diagnosis of Autism with which she can compare her figures.

So

how do I get hold of the latest accurate prevalence statistics? Prof Regan is currently of the view that the “so called increase” is largely down to greater recognition of autism and better diagnosis.

Does anyone have any relevant views to pass on – which I can feed back. They need to be suitably backed up by research – of course!

This could be a very exciting opportunity, or it could be a damp squib, but she appears interested, and she is very influential in the world of Obstetrics and Gynaecology, and to some extent in the medical profession more widely.. She is going to a conference in Paris on Thursday night at which she would like to raise the possibility of a connection.

Please forward this request to other email groups who might have the answer or any useful ideas.

I need to get back to her by Thursday latest.

Hopefully, Alison

[Guest guest]

Reading this email has prompted me to remember that when I bled at 31 weeks with Luke and was rushed into hospital - I am sure I was given an injection to stabilise things.

I cannot recall what injection it was? Has anyone experienced something similar?

I wonder if this had thermisol in it? I am going to try and find out.

Nicola

AntiPhospholipid Syndrome/Autism/Prevalence Statistics

I have just received an interesting phone call from a Specialist who treated me at St s Paddington, for Recurrent Miscarriage (3 prior to the birth of my autistic son) and one miscarriage in between the births of each of my neurotypical sons.

A few years ago I asked her about the possibility of a link between Antiphospholipid Syndrome (APS) which is a blood clotting problem which causes recurrent miscarriages, and Autism. This was to some extent based on my hunch that it is too much of a coincidence that the mothers of autistic children are often (but not always – which is why this puzzle is so complicated)

either :

-Rhesus Negative

-Recurrent Miscarriers (and have therefore had Anti-D or Rhogam injections probably containing Thiomersal)

-People with unexplained sub fertility

-People with explained sub fertility

-People who have a family history of auto immune disorders

-People with a family history of immune problems eg allergies etc

-People with problems processing heavy metals

or all or any of the above (and those with none at all)

Long story short, my Specialist said that she has in fact seen what appears to be quite a few more autistic babies born out of her clinics over the past few years. She was concerned that there are no accurate prevalence studies of diagnosis of Autism with which she can compare her figures.

So

how do I get hold of the latest accurate prevalence statistics? Prof Regan is currently of the view that the “so called increase” is largely down to greater recognition of autism and better diagnosis.

Does anyone have any relevant views to pass on – which I can feed back. They need to be suitably backed up by research – of course!

This could be a very exciting opportunity, or it could be a damp squib, but she appears interested, and she is very influential in the world of Obstetrics and Gynaecology, and to some extent in the medical profession more widely.. She is going to a conference in Paris on Thursday night at which she would like to raise the possibility of a connection.

Please forward this request to other email groups who might have the answer or any useful ideas.

I need to get back to her by Thursday latest.

Hopefully, Alison

[Guest guest]

Hope these abstracts can be of some help:

J Child Neurol. 1999 Jun;14(6):388-94.

Familial clustering of autoimmune disorders and evaluation of medical risk

factors in autism.

Comi AM, Zimmerman AW, Frye VH, Law PA, Peeden JN.

s Hopkins Hospital, Division of Pediatric Neurology, Baltimore, MD 21212,

USA. acomimd@...

Autism is an age-dependent neurologic disorder that is often associated with

autoimmune disorders in the patients' relatives. To evaluate the frequency of

autoimmune disorders, as well as various prenatal and postnatal events in

autism, we surveyed the families of 61 autistic patients and 46 healthy controls

using questionnaires. The mean number of autoimmune disorders was greater in

families with autism; 46% had two or more members with autoimmune disorders. As

the number of family members with autoimmune disorders increased from one to

three, the risk of autism was greater, with an odds ratio that increased from

1.9 to 5.5, respectively. In mothers and first-degree relatives of autistic

children, there were more autoimmune disorders (16% and 21%) as compared to

controls (2% and 4%), with odds ratios of 8.8 and 6.0, respectively. The most

common autoimmune disorders in both groups were type 1 diabetes, adult

rheumatoid arthritis, hypothyroidism, and systemic lupus erythematosus.

Forty-six percent of the autism group reported having relatives with rheumatoid

diseases, as compared to 26% of the controls. Prenatal maternal urinary tract,

upper respiratory, and vaginal infections; asphyxia; prematurity, and seizures

were more common in the autistic group, although the differences were not

significant. Thirty-nine percent of the controls, but only 11% of the autistic,

group, reported allergies. An increased number of autoimmune disorders suggests

that in some families with autism, immune dysfunction could interact with

various environmental factors to play a role in autism pathogenesis.

PMID: 10385847 [PubMed - indexed for MEDLINE]

1: Mol Psychiatry. 2004 Sep;9(9):833-45.

Neurotoxic effects of postnatal thimerosal are mouse strain dependent.

Hornig M et al. Jerome L and Dawn Greene Infectious Disease Laboratory, Department of

Epidemiology, Mailman School of Public Health, Columbia University, New York, NY

10032, USA. mady.hornig@...

The developing brain is uniquely susceptible to the neurotoxic hazard posed by

mercurials. Host differences in maturation, metabolism, nutrition, sex, and

autoimmunity influence outcomes. How population-based variability affects the

safety of the ethylmercury-containing vaccine preservative, thimerosal, is

unknown. Reported increases in the prevalence of autism, a highly heritable

neuropsychiatric condition, are intensifying public focus on environmental

exposures such as thimerosal. Immune profiles and family history in autism are

frequently consistent with autoimmunity. We hypothesized that autoimmune

propensity influences outcomes in mice following thimerosal challenges that

mimic routine childhood immunizations. Autoimmune disease-sensitive SJL/J mice

showed growth delay; reduced locomotion; exaggerated response to novelty; and

densely packed, hyperchromic hippocampal neurons with altered glutamate

receptors and transporters. Strains resistant to autoimmunity, C57BL/6J and

BALB/cJ, were not susceptible. These findings implicate genetic influences and

provide a model for investigating thimerosal-related neurotoxicity.

PMID: 15184908 [PubMed - indexed for MEDLINE]

THESE TALK ABOUT MATERNAL INFECTION BEING A RISK FACTOR :

2: J Neurosci. 2003 Jan 1;23(1):297-302.

Maternal influenza infection causes marked behavioral and pharmacological

changes in the offspring.

free full text available from : http://www.jneurosci.org/cgi/content/full/23/1/297

Shi L, Fatemi SH, Sidwell RW, PH. Biology Division, California Institute of Technology, Pasadena, California

91125, USA.

Maternal viral infection is known to increase the risk for schizophrenia and

autism in the offspring. Using this observation in an animal model, we find that

respiratory infection of pregnant mice (both BALB/c and C57BL/6 strains) with

the human influenza virus yields offspring that display highly abnormal

behavioral responses as adults. As in schizophrenia and autism, these offspring

display deficits in prepulse inhibition (PPI) in the acoustic startle response.

Compared with control mice, the infected mice also display striking responses to

the acute administration of antipsychotic (clozapine and chlorpromazine) and

psychomimetic (ketamine) drugs. Moreover, these mice are deficient in

exploratory behavior in both open-field and novel-object tests, and they are

deficient in social interaction. At least some of these behavioral changes

likely are attributable to the maternal immune response itself. That is,

maternal injection of the synthetic double-stranded RNA

polyinosinic-polycytidylic acid causes a PPI deficit in the offspring in the

absence of virus. Therefore, maternal viral infection has a profound effect on

the behavior of adult offspring, probably via an effect of the maternal immune

response on the fetus.

PMID: 12514227 [PubMed - indexed for MEDLINE]

1: Synapse. 2005 Aug;57(2):91-9.

Prenatal viral infection in mouse causes differential expression of genes in

brains of mouse progeny: a potential animal model for schizophrenia and autism.

Fatemi SH, Pearce DA, AI, Sidwell RW. University of Minnesota,

Department of Psychiatry, Division of Neuroscience Research,

Minneapolis, Minnesota 55455, USA. fatem002@...

Schizophrenia and autism are neurodevelopmental disorders with genetic and

environmental etiologies. Prenatal viral infection has been associated with both

disorders. We investigated the effects of prenatal viral infection on gene

regulation in offspring of Balb-c mice using microarray technology. The results

showed significant upregulation of 21 genes and downregulation of 18 genes in

the affected neonatal brain homogenates spanning gene families affecting cell

structure and function, namely, cytosolic chaperone system, HSC70, Bicaudal D,

aquaporin 4, carbonic anhydrase 3, glycine receptor, norepinephrine transporter,

and myelin basic protein. We also verified the results using QPCR measurements

of selected mRNA species. These results show for the first time that prenatal

human influenza viral infection on day 9 of pregnancy leads to alterations in a

subset of genes in brains of exposed offspring, potentially leading to permanent

changes in brain structure and function. Copyright © 2005 Wiley-Liss, Inc.

PMID: 15906383 [PubMed - indexed for MEDLINE]

J Neurosci. 2006 May 3;26(18):4752-62.

The time of prenatal immune challenge determines the specificity of

inflammation-mediated brain and behavioral pathology.

Meyer U, Nyffeler M, Engler A, Urwyler A, Schedlowski M, Knuesel I, Yee BK,

Feldon J.

Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology

Zurich, CH-8603 Schwerzenbach, Switzerland.

Disturbance to early brain development is implicated in several neuropsychiatric

disorders including autism, schizophrenia, and mental retardation.

Epidemiological studies have indicated that the risk of developing these

disorders is enhanced by prenatal maternal infection, presumably as a result of

neurodevelopmental defects triggered by cytokine-related inflammatory events.

Here, we demonstrate that the effects of maternal immune challenge between

middle and late gestation periods in mice are dissociable in terms of fetal

brain cytokine responses to maternal inflammation and the pathological

consequences in brain and behavior. Specifically, the relative expression of

pro- and anti-inflammatory cytokines in the fetal brains in response to maternal

immune challenge may be an important determinant among other developmental

factors for the precise pathological profile emerging in later life. Thus, the

middle and late gestation periods correspond to two windows with differing

vulnerability to adult behavioral dysfunction, brain neuropathology in early

adolescence, and of the acute cytokine responses in the fetal brain.

PMID: 16672647 [PubMed - indexed for MEDLINE]

3: Curr Opin Neurobiol. 2002 Feb;12(1):115-8.

Maternal infection: window on neuroimmune interactions in fetal brain

development and mental illness.

PH.

Biology Division, California Institute of Technology, Pasadena, California

91125, USA. php@...

Direct viral infection of the developing brain can have disastrous consequences

for the fetus. More subtle and perhaps more insidious are viral infections of

the pregnant mother, which can have long-lasting effects such as an increased

risk of schizophrenia in the offspring. A recent mouse model has shown that

respiratory infection in the pregnant mother leads to marked behavioral and

pharmacological abnormalities in the offspring, some of which are relevant for

schizophrenia and autism. This effect on fetal brain development might be caused

by the maternal antiviral immune response, possibly mediated by cytokines.

PMID: 11861174 [PubMed - indexed for MEDLINE]

>> I have just received an interesting phone call from a Specialist who> treated me at St s Paddington, for Recurrent Miscarriage (3 prior> to the birth of my autistic son) and one miscarriage in between the> births of each of my neurotypical sons. > > A few years ago I asked her about the possibility of a link between> Antiphospholipid Syndrome (APS) which is a blood clotting problem which> causes recurrent miscarriages, and Autism. This was to some extent based> on my hunch that it is too much of a coincidence that the mothers of> autistic children are often (but not always - which is why this puzzle> is so complicated)> either :> > -Rhesus Negative> -Recurrent Miscarriers (and have therefore had Anti-D or Rhogam> injections probably containing Thiomersal)> -People with unexplained sub fertility> -People with explained sub fertility > -People who have a family history of auto immune disorders > -People with a family history of immune problems eg allergies etc> -People with problems processing heavy metals> > or all or any of the above (and those with none at all)> > Long story short, my Specialist said that she has in fact seen what> appears to be quite a few more autistic babies born out of her clinics> over the past few years. She was concerned that there are no accurate> prevalence studies of diagnosis of Autism with which she can compare her> figures. > > So> > a. how do I get hold of the latest accurate prevalence statistics?> Prof Regan is currently of the view that the "so called increase" is> largely down to greater recognition of autism and better diagnosis. > b. Does anyone have any relevant views to pass on - which I can> feed back. They need to be suitably backed up by research - of course! > > This could be a very exciting opportunity, or it could be a damp squib,> but she appears interested, and she is very influential in the world of> Obstetrics and Gynaecology, and to some extent in the medical profession> more widely.. She is going to a conference in Paris on Thursday night at> which she would like to raise the possibility of a connection. > Please forward this request to other email groups who might have the> answer or any useful ideas. > > I need to get back to her by Thursday latest. > Hopefully, Alison>

[Guest guest]

Hope these abstracts can be of some help:

J Child Neurol. 1999 Jun;14(6):388-94.

Familial clustering of autoimmune disorders and evaluation of medical risk

factors in autism.

Comi AM, Zimmerman AW, Frye VH, Law PA, Peeden JN.

s Hopkins Hospital, Division of Pediatric Neurology, Baltimore, MD 21212,

USA. acomimd@...

Autism is an age-dependent neurologic disorder that is often associated with

autoimmune disorders in the patients' relatives. To evaluate the frequency of

autoimmune disorders, as well as various prenatal and postnatal events in

autism, we surveyed the families of 61 autistic patients and 46 healthy controls

using questionnaires. The mean number of autoimmune disorders was greater in

families with autism; 46% had two or more members with autoimmune disorders. As

the number of family members with autoimmune disorders increased from one to

three, the risk of autism was greater, with an odds ratio that increased from

1.9 to 5.5, respectively. In mothers and first-degree relatives of autistic

children, there were more autoimmune disorders (16% and 21%) as compared to

controls (2% and 4%), with odds ratios of 8.8 and 6.0, respectively. The most

common autoimmune disorders in both groups were type 1 diabetes, adult

rheumatoid arthritis, hypothyroidism, and systemic lupus erythematosus.

Forty-six percent of the autism group reported having relatives with rheumatoid

diseases, as compared to 26% of the controls. Prenatal maternal urinary tract,

upper respiratory, and vaginal infections; asphyxia; prematurity, and seizures

were more common in the autistic group, although the differences were not

significant. Thirty-nine percent of the controls, but only 11% of the autistic,

group, reported allergies. An increased number of autoimmune disorders suggests

that in some families with autism, immune dysfunction could interact with

various environmental factors to play a role in autism pathogenesis.

PMID: 10385847 [PubMed - indexed for MEDLINE]

1: Mol Psychiatry. 2004 Sep;9(9):833-45.

Neurotoxic effects of postnatal thimerosal are mouse strain dependent.

Hornig M et al. Jerome L and Dawn Greene Infectious Disease Laboratory, Department of

Epidemiology, Mailman School of Public Health, Columbia University, New York, NY

10032, USA. mady.hornig@...

The developing brain is uniquely susceptible to the neurotoxic hazard posed by

mercurials. Host differences in maturation, metabolism, nutrition, sex, and

autoimmunity influence outcomes. How population-based variability affects the

safety of the ethylmercury-containing vaccine preservative, thimerosal, is

unknown. Reported increases in the prevalence of autism, a highly heritable

neuropsychiatric condition, are intensifying public focus on environmental

exposures such as thimerosal. Immune profiles and family history in autism are

frequently consistent with autoimmunity. We hypothesized that autoimmune

propensity influences outcomes in mice following thimerosal challenges that

mimic routine childhood immunizations. Autoimmune disease-sensitive SJL/J mice

showed growth delay; reduced locomotion; exaggerated response to novelty; and

densely packed, hyperchromic hippocampal neurons with altered glutamate

receptors and transporters. Strains resistant to autoimmunity, C57BL/6J and

BALB/cJ, were not susceptible. These findings implicate genetic influences and

provide a model for investigating thimerosal-related neurotoxicity.

PMID: 15184908 [PubMed - indexed for MEDLINE]

THESE TALK ABOUT MATERNAL INFECTION BEING A RISK FACTOR :

2: J Neurosci. 2003 Jan 1;23(1):297-302.

Maternal influenza infection causes marked behavioral and pharmacological

changes in the offspring.

free full text available from : http://www.jneurosci.org/cgi/content/full/23/1/297

Shi L, Fatemi SH, Sidwell RW, PH. Biology Division, California Institute of Technology, Pasadena, California

91125, USA.

Maternal viral infection is known to increase the risk for schizophrenia and

autism in the offspring. Using this observation in an animal model, we find that

respiratory infection of pregnant mice (both BALB/c and C57BL/6 strains) with

the human influenza virus yields offspring that display highly abnormal

behavioral responses as adults. As in schizophrenia and autism, these offspring

display deficits in prepulse inhibition (PPI) in the acoustic startle response.

Compared with control mice, the infected mice also display striking responses to

the acute administration of antipsychotic (clozapine and chlorpromazine) and

psychomimetic (ketamine) drugs. Moreover, these mice are deficient in

exploratory behavior in both open-field and novel-object tests, and they are

deficient in social interaction. At least some of these behavioral changes

likely are attributable to the maternal immune response itself. That is,

maternal injection of the synthetic double-stranded RNA

polyinosinic-polycytidylic acid causes a PPI deficit in the offspring in the

absence of virus. Therefore, maternal viral infection has a profound effect on

the behavior of adult offspring, probably via an effect of the maternal immune

response on the fetus.

PMID: 12514227 [PubMed - indexed for MEDLINE]

1: Synapse. 2005 Aug;57(2):91-9.

Prenatal viral infection in mouse causes differential expression of genes in

brains of mouse progeny: a potential animal model for schizophrenia and autism.

Fatemi SH, Pearce DA, AI, Sidwell RW. University of Minnesota,

Department of Psychiatry, Division of Neuroscience Research,

Minneapolis, Minnesota 55455, USA. fatem002@...

Schizophrenia and autism are neurodevelopmental disorders with genetic and

environmental etiologies. Prenatal viral infection has been associated with both

disorders. We investigated the effects of prenatal viral infection on gene

regulation in offspring of Balb-c mice using microarray technology. The results

showed significant upregulation of 21 genes and downregulation of 18 genes in

the affected neonatal brain homogenates spanning gene families affecting cell

structure and function, namely, cytosolic chaperone system, HSC70, Bicaudal D,

aquaporin 4, carbonic anhydrase 3, glycine receptor, norepinephrine transporter,

and myelin basic protein. We also verified the results using QPCR measurements

of selected mRNA species. These results show for the first time that prenatal

human influenza viral infection on day 9 of pregnancy leads to alterations in a

subset of genes in brains of exposed offspring, potentially leading to permanent

changes in brain structure and function. Copyright © 2005 Wiley-Liss, Inc.

PMID: 15906383 [PubMed - indexed for MEDLINE]

J Neurosci. 2006 May 3;26(18):4752-62.

The time of prenatal immune challenge determines the specificity of

inflammation-mediated brain and behavioral pathology.

Meyer U, Nyffeler M, Engler A, Urwyler A, Schedlowski M, Knuesel I, Yee BK,

Feldon J.

Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology

Zurich, CH-8603 Schwerzenbach, Switzerland.

Disturbance to early brain development is implicated in several neuropsychiatric

disorders including autism, schizophrenia, and mental retardation.

Epidemiological studies have indicated that the risk of developing these

disorders is enhanced by prenatal maternal infection, presumably as a result of

neurodevelopmental defects triggered by cytokine-related inflammatory events.

Here, we demonstrate that the effects of maternal immune challenge between

middle and late gestation periods in mice are dissociable in terms of fetal

brain cytokine responses to maternal inflammation and the pathological

consequences in brain and behavior. Specifically, the relative expression of

pro- and anti-inflammatory cytokines in the fetal brains in response to maternal

immune challenge may be an important determinant among other developmental

factors for the precise pathological profile emerging in later life. Thus, the

middle and late gestation periods correspond to two windows with differing

vulnerability to adult behavioral dysfunction, brain neuropathology in early

adolescence, and of the acute cytokine responses in the fetal brain.

PMID: 16672647 [PubMed - indexed for MEDLINE]

3: Curr Opin Neurobiol. 2002 Feb;12(1):115-8.

Maternal infection: window on neuroimmune interactions in fetal brain

development and mental illness.

PH.

Biology Division, California Institute of Technology, Pasadena, California

91125, USA. php@...

Direct viral infection of the developing brain can have disastrous consequences

for the fetus. More subtle and perhaps more insidious are viral infections of

the pregnant mother, which can have long-lasting effects such as an increased

risk of schizophrenia in the offspring. A recent mouse model has shown that

respiratory infection in the pregnant mother leads to marked behavioral and

pharmacological abnormalities in the offspring, some of which are relevant for

schizophrenia and autism. This effect on fetal brain development might be caused

by the maternal antiviral immune response, possibly mediated by cytokines.

PMID: 11861174 [PubMed - indexed for MEDLINE]

>> I have just received an interesting phone call from a Specialist who> treated me at St s Paddington, for Recurrent Miscarriage (3 prior> to the birth of my autistic son) and one miscarriage in between the> births of each of my neurotypical sons. > > A few years ago I asked her about the possibility of a link between> Antiphospholipid Syndrome (APS) which is a blood clotting problem which> causes recurrent miscarriages, and Autism. This was to some extent based> on my hunch that it is too much of a coincidence that the mothers of> autistic children are often (but not always - which is why this puzzle> is so complicated)> either :> > -Rhesus Negative> -Recurrent Miscarriers (and have therefore had Anti-D or Rhogam> injections probably containing Thiomersal)> -People with unexplained sub fertility> -People with explained sub fertility > -People who have a family history of auto immune disorders > -People with a family history of immune problems eg allergies etc> -People with problems processing heavy metals> > or all or any of the above (and those with none at all)> > Long story short, my Specialist said that she has in fact seen what> appears to be quite a few more autistic babies born out of her clinics> over the past few years. She was concerned that there are no accurate> prevalence studies of diagnosis of Autism with which she can compare her> figures. > > So> > a. how do I get hold of the latest accurate prevalence statistics?> Prof Regan is currently of the view that the "so called increase" is> largely down to greater recognition of autism and better diagnosis. > b. Does anyone have any relevant views to pass on - which I can> feed back. They need to be suitably backed up by research - of course! > > This could be a very exciting opportunity, or it could be a damp squib,> but she appears interested, and she is very influential in the world of> Obstetrics and Gynaecology, and to some extent in the medical profession> more widely.. She is going to a conference in Paris on Thursday night at> which she would like to raise the possibility of a connection. > Please forward this request to other email groups who might have the> answer or any useful ideas. > > I need to get back to her by Thursday latest. > Hopefully, Alison>

[Guest guest]

I had 2 steroid injections - i wonder too.

margaret

AntiPhospholipid Syndrome/Autism/Prevalence Statistics

I have just received an interesting phone call from a Specialist who treated me at St s Paddington, for Recurrent Miscarriage (3 prior to the birth of my autistic son) and one miscarriage in between the births of each of my neurotypical sons.

A few years ago I asked her about the possibility of a link between Antiphospholipid Syndrome (APS) which is a blood clotting problem which causes recurrent miscarriages, and Autism. This was to some extent based on my hunch that it is too much of a coincidence that the mothers of autistic children are often (but not always – which is why this puzzle is so complicated)

either :

-Rhesus Negative

-Recurrent Miscarriers (and have therefore had Anti-D or Rhogam injections probably containing Thiomersal)

-People with unexplained sub fertility

-People with explained sub fertility

-People who have a family history of auto immune disorders

-People with a family history of immune problems eg allergies etc

-People with problems processing heavy metals

or all or any of the above (and those with none at all)

Long story short, my Specialist said that she has in fact seen what appears to be quite a few more autistic babies born out of her clinics over the past few years. She was concerned that there are no accurate prevalence studies of diagnosis of Autism with which she can compare her figures.

So

how do I get hold of the latest accurate prevalence statistics? Prof Regan is currently of the view that the “so called increase” is largely down to greater recognition of autism and better diagnosis.

Does anyone have any relevant views to pass on – which I can feed back. They need to be suitably backed up by research – of course!

This could be a very exciting opportunity, or it could be a damp squib, but she appears interested, and she is very influential in the world of Obstetrics and Gynaecology, and to some extent in the medical profession more widely.. She is going to a conference in Paris on Thursday night at which she would like to raise the possibility of a connection.

Please forward this request to other email groups who might have the answer or any useful ideas.

I need to get back to her by Thursday latest.

Hopefully, Alison

__________ NOD32 1.1581 (20060606) Information __________This message was checked by NOD32 antivirus system.http://www.eset.com

[Guest guest]

I had 2 steroid injections - i wonder too.

margaret

AntiPhospholipid Syndrome/Autism/Prevalence Statistics

I have just received an interesting phone call from a Specialist who treated me at St s Paddington, for Recurrent Miscarriage (3 prior to the birth of my autistic son) and one miscarriage in between the births of each of my neurotypical sons.

A few years ago I asked her about the possibility of a link between Antiphospholipid Syndrome (APS) which is a blood clotting problem which causes recurrent miscarriages, and Autism. This was to some extent based on my hunch that it is too much of a coincidence that the mothers of autistic children are often (but not always – which is why this puzzle is so complicated)

either :

-Rhesus Negative

-Recurrent Miscarriers (and have therefore had Anti-D or Rhogam injections probably containing Thiomersal)

-People with unexplained sub fertility

-People with explained sub fertility

-People who have a family history of auto immune disorders

-People with a family history of immune problems eg allergies etc

-People with problems processing heavy metals

or all or any of the above (and those with none at all)

Long story short, my Specialist said that she has in fact seen what appears to be quite a few more autistic babies born out of her clinics over the past few years. She was concerned that there are no accurate prevalence studies of diagnosis of Autism with which she can compare her figures.

So

how do I get hold of the latest accurate prevalence statistics? Prof Regan is currently of the view that the “so called increase” is largely down to greater recognition of autism and better diagnosis.

Does anyone have any relevant views to pass on – which I can feed back. They need to be suitably backed up by research – of course!

This could be a very exciting opportunity, or it could be a damp squib, but she appears interested, and she is very influential in the world of Obstetrics and Gynaecology, and to some extent in the medical profession more widely.. She is going to a conference in Paris on Thursday night at which she would like to raise the possibility of a connection.

Please forward this request to other email groups who might have the answer or any useful ideas.

I need to get back to her by Thursday latest.

Hopefully, Alison

__________ NOD32 1.1581 (20060606) Information __________This message was checked by NOD32 antivirus system.http://www.eset.com

[Guest guest]

Hi Alison, just re-read you post and something else came mind, only

anecdotal this time: my mum also had numerour miscarriages before she

had me, and she later on developed MS.

Both me and my brother are nt, although I am positive my brother would

have been ASD were he to be hit by today's amount of toxic crap - he is

very technically minded, slightly dyslexic, started talking late (was

almost three) and he is not very eloquent, even though his social skills

are more or less nt he is a bit 'slow' socially.

Natasa

>

> I have just received an interesting phone call from a Specialist who

> treated me at St s Paddington, for Recurrent Miscarriage (3 prior

> to the birth of my autistic son) and one miscarriage in between the

> births of each of my neurotypical sons.

>

> A few years ago I asked her about the possibility of a link between

> Antiphospholipid Syndrome (APS) which is a blood clotting problem

which

> causes recurrent miscarriages, and Autism. This was to some extent

based

> on my hunch that it is too much of a coincidence that the mothers of

> autistic children are often (but not always - which is why this puzzle

> is so complicated)

> either :

>

> -Rhesus Negative

> -Recurrent Miscarriers (and have therefore had Anti-D or Rhogam

> injections probably containing Thiomersal)

> -People with unexplained sub fertility

> -People with explained sub fertility

> -People who have a family history of auto immune disorders

> -People with a family history of immune problems eg allergies etc

> -People with problems processing heavy metals

>

> or all or any of the above (and those with none at all)

>

> Long story short, my Specialist said that she has in fact seen what

> appears to be quite a few more autistic babies born out of her clinics

> over the past few years. She was concerned that there are no accurate

> prevalence studies of diagnosis of Autism with which she can compare

her

> figures.

>

> So

>

> a. how do I get hold of the latest accurate prevalence statistics?

> Prof Regan is currently of the view that the " so called increase " is

> largely down to greater recognition of autism and better diagnosis.

> b. Does anyone have any relevant views to pass on - which I can

> feed back. They need to be suitably backed up by research - of course!

>

> This could be a very exciting opportunity, or it could be a damp

squib,

> but she appears interested, and she is very influential in the world

of

> Obstetrics and Gynaecology, and to some extent in the medical

profession

> more widely.. She is going to a conference in Paris on Thursday night

at

> which she would like to raise the possibility of a connection.

> Please forward this request to other email groups who might have the

> answer or any useful ideas.

>

> I need to get back to her by Thursday latest.

> Hopefully, Alison

>

[Guest guest]

Hi Alison, just re-read you post and something else came mind, only

anecdotal this time: my mum also had numerour miscarriages before she

had me, and she later on developed MS.

Both me and my brother are nt, although I am positive my brother would

have been ASD were he to be hit by today's amount of toxic crap - he is

very technically minded, slightly dyslexic, started talking late (was

almost three) and he is not very eloquent, even though his social skills

are more or less nt he is a bit 'slow' socially.

Natasa

>

> I have just received an interesting phone call from a Specialist who

> treated me at St s Paddington, for Recurrent Miscarriage (3 prior

> to the birth of my autistic son) and one miscarriage in between the

> births of each of my neurotypical sons.

>

> A few years ago I asked her about the possibility of a link between

> Antiphospholipid Syndrome (APS) which is a blood clotting problem

which

> causes recurrent miscarriages, and Autism. This was to some extent

based

> on my hunch that it is too much of a coincidence that the mothers of

> autistic children are often (but not always - which is why this puzzle

> is so complicated)

> either :

>

> -Rhesus Negative

> -Recurrent Miscarriers (and have therefore had Anti-D or Rhogam

> injections probably containing Thiomersal)

> -People with unexplained sub fertility

> -People with explained sub fertility

> -People who have a family history of auto immune disorders

> -People with a family history of immune problems eg allergies etc

> -People with problems processing heavy metals

>

> or all or any of the above (and those with none at all)

>

> Long story short, my Specialist said that she has in fact seen what

> appears to be quite a few more autistic babies born out of her clinics

> over the past few years. She was concerned that there are no accurate

> prevalence studies of diagnosis of Autism with which she can compare

her

> figures.

>

> So

>

> a. how do I get hold of the latest accurate prevalence statistics?

> Prof Regan is currently of the view that the " so called increase " is

> largely down to greater recognition of autism and better diagnosis.

> b. Does anyone have any relevant views to pass on - which I can

> feed back. They need to be suitably backed up by research - of course!

>

> This could be a very exciting opportunity, or it could be a damp

squib,

> but she appears interested, and she is very influential in the world

of

> Obstetrics and Gynaecology, and to some extent in the medical

profession

> more widely.. She is going to a conference in Paris on Thursday night

at

> which she would like to raise the possibility of a connection.

> Please forward this request to other email groups who might have the

> answer or any useful ideas.

>

> I need to get back to her by Thursday latest.

> Hopefully, Alison

>

[Guest guest]

I have/had Antiphospholipid syndrome - I know it as syndrome.

I was diagnosed by Dr (I didn't realise at first it was the

man himself) when I went as a private patient. He works at St

' in London. I was also diagnosed with Sjogren's (it's an

autoimmune disease like Lupus). I had a history of early miscarriage

and over 20 years of endometriosis.

Dr is lovely. He offered to take me on as an NHS patient (he

wrote a really lovely letter to my GP and making this offer clear).

I wanted to mention this incase it is useful to anyone. Going

private was the only option after 3 regional referrals to

rheumatologists (one private). It seems autoimmune diseases are not

well diagnosed at all.

I've been treating myself (as advised by DAN we're treating the

family) and have huge improvements in my health - I am off quinine

and aspirin (this thinned my blood - but I think the healthy dose of

EFA is doing the same job). My endometriosis has disappeared!. My

inflamation and rheumatism have gone - but I did find out not long

ago that I had clostridia (but I now know I am on the spectrum). I

am in the process of dealing with this and I hope to see more

improvements.

I lecture electronic engineering (which is pretty spectrum isn't it :-

) ). I do see these autoimmune/hypothyroid health symptoms all too

often in undergraduate students - especially science/engineering

students and espceially the girls. I really believe there is a lot

of endometriosis in particular in science and engineering.

We are now beginning to see ASD undergraduate students but I'm afraid

the numbers are too small to be useful (I'd be interested in any

pointers here - if anyone does know of published higher education

stats on this.) I would love to do a health screen on students and

compare disciplines. I believe we might well see significantly more

intestinal dysbiosis in the scientists and engineers (including

medics and mathematicians).

Best wishes

Sandy

> >

> > I have just received an interesting phone call from a Specialist

who

> > treated me at St s Paddington, for Recurrent Miscarriage (3

prior

> > to the birth of my autistic son) and one miscarriage in between

the

> > births of each of my neurotypical sons.

> >

> > A few years ago I asked her about the possibility of a link

between

> > Antiphospholipid Syndrome (APS) which is a blood clotting problem

> which

> > causes recurrent miscarriages, and Autism. This was to some extent

> based

> > on my hunch that it is too much of a coincidence that the mothers

of

> > autistic children are often (but not always - which is why this

puzzle

> > is so complicated)

> > either :

> >

> > -Rhesus Negative

> > -Recurrent Miscarriers (and have therefore had Anti-D or Rhogam

> > injections probably containing Thiomersal)

> > -People with unexplained sub fertility

> > -People with explained sub fertility

> > -People who have a family history of auto immune disorders

> > -People with a family history of immune problems eg allergies etc

> > -People with problems processing heavy metals

> >

> > or all or any of the above (and those with none at all)

> >

> > Long story short, my Specialist said that she has in fact seen

what

> > appears to be quite a few more autistic babies born out of her

clinics

> > over the past few years. She was concerned that there are no

accurate

> > prevalence studies of diagnosis of Autism with which she can

compare

> her

> > figures.

> >

> > So

> >

> > a. how do I get hold of the latest accurate prevalence statistics?

> > Prof Regan is currently of the view that the " so called increase "

is

> > largely down to greater recognition of autism and better

diagnosis.

> > b. Does anyone have any relevant views to pass on - which I can

> > feed back. They need to be suitably backed up by research - of

course!

> >

> > This could be a very exciting opportunity, or it could be a damp

> squib,

> > but she appears interested, and she is very influential in the

world

> of

> > Obstetrics and Gynaecology, and to some extent in the medical

> profession

> > more widely.. She is going to a conference in Paris on Thursday

night

> at

> > which she would like to raise the possibility of a connection.

> > Please forward this request to other email groups who might have

the

> > answer or any useful ideas.

> >

> > I need to get back to her by Thursday latest.

> > Hopefully, Alison

> >

>

[Guest guest]

Please post what you find out. I also had a heavy bleed with Tom at

29 weeks and was rushed into hospital and injected - I cannot

remember what it was (expect neither of us was in a fit state to

register anything at that time!)

I'll try investigating as well.

Gail

>

> Reading this email has prompted me to remember that when I bled at

31 weeks with Luke and was rushed into hospital - I am sure I was

given an injection to stabilise things.

>

> I cannot recall what injection it was? Has anyone experienced

something similar?

>

> I wonder if this had thermisol in it? I am going to try and find

out.

>

> Nicola

> AntiPhospholipid

Syndrome/Autism/Prevalence Statistics

>

>

> I have just received an interesting phone call from a

Specialist who treated me at St s Paddington, for Recurrent

Miscarriage (3 prior to the birth of my autistic son) and one

miscarriage in between the births of each of my neurotypical sons.

>

>

>

> A few years ago I asked her about the possibility of a link

between Antiphospholipid Syndrome (APS) which is a blood clotting

problem which causes recurrent miscarriages, and Autism. This was to

some extent based on my hunch that it is too much of a coincidence

that the mothers of autistic children are often (but not always -

which is why this puzzle is so complicated)

>

> either :

>

>

>

> -Rhesus Negative

>

> -Recurrent Miscarriers (and have therefore had Anti-D or Rhogam

injections probably containing Thiomersal)

>

> -People with unexplained sub fertility

>

> -People with explained sub fertility

>

> -People who have a family history of auto immune disorders

>

> -People with a family history of immune problems eg allergies

etc

>

> -People with problems processing heavy metals

>

>

>

> or all or any of the above (and those with none at all)

>

>

>

> Long story short, my Specialist said that she has in fact seen

what appears to be quite a few more autistic babies born out of her

clinics over the past few years. She was concerned that there are no

accurate prevalence studies of diagnosis of Autism with which she

can compare her figures.

>

>

>

> So

>

>

>

> 1.. how do I get hold of the latest accurate prevalence

statistics? Prof Regan is currently of the view that the " so called

increase " is largely down to greater recognition of autism and

better diagnosis.

> 2.. Does anyone have any relevant views to pass on - which I

can feed back. They need to be suitably backed up by research - of

course!

>

>

> This could be a very exciting opportunity, or it could be a damp

squib, but she appears interested, and she is very influential in

the world of Obstetrics and Gynaecology, and to some extent in the

medical profession more widely.. She is going to a conference in

Paris on Thursday night at which she would like to raise the

possibility of a connection.

>

> Please forward this request to other email groups who might have

the answer or any useful ideas.

>

>

>

> I need to get back to her by Thursday latest.

>

> Hopefully, Alison

>

[Guest guest]

Please post what you find out. I also had a heavy bleed with Tom at

29 weeks and was rushed into hospital and injected - I cannot

remember what it was (expect neither of us was in a fit state to

register anything at that time!)

I'll try investigating as well.

Gail

>

> Reading this email has prompted me to remember that when I bled at

31 weeks with Luke and was rushed into hospital - I am sure I was

given an injection to stabilise things.

>

> I cannot recall what injection it was? Has anyone experienced

something similar?

>

> I wonder if this had thermisol in it? I am going to try and find

out.

>

> Nicola

> AntiPhospholipid

Syndrome/Autism/Prevalence Statistics

>

>

> I have just received an interesting phone call from a

Specialist who treated me at St s Paddington, for Recurrent

Miscarriage (3 prior to the birth of my autistic son) and one

miscarriage in between the births of each of my neurotypical sons.

>

>

>

> A few years ago I asked her about the possibility of a link

between Antiphospholipid Syndrome (APS) which is a blood clotting

problem which causes recurrent miscarriages, and Autism. This was to

some extent based on my hunch that it is too much of a coincidence

that the mothers of autistic children are often (but not always -

which is why this puzzle is so complicated)

>

> either :

>

>

>

> -Rhesus Negative

>

> -Recurrent Miscarriers (and have therefore had Anti-D or Rhogam

injections probably containing Thiomersal)

>

> -People with unexplained sub fertility

>

> -People with explained sub fertility

>

> -People who have a family history of auto immune disorders

>

> -People with a family history of immune problems eg allergies

etc

>

> -People with problems processing heavy metals

>

>

>

> or all or any of the above (and those with none at all)

>

>

>

> Long story short, my Specialist said that she has in fact seen

what appears to be quite a few more autistic babies born out of her

clinics over the past few years. She was concerned that there are no

accurate prevalence studies of diagnosis of Autism with which she

can compare her figures.

>

>

>

> So

>

>

>

> 1.. how do I get hold of the latest accurate prevalence

statistics? Prof Regan is currently of the view that the " so called

increase " is largely down to greater recognition of autism and

better diagnosis.

> 2.. Does anyone have any relevant views to pass on - which I

can feed back. They need to be suitably backed up by research - of

course!

>

>

> This could be a very exciting opportunity, or it could be a damp

squib, but she appears interested, and she is very influential in

the world of Obstetrics and Gynaecology, and to some extent in the

medical profession more widely.. She is going to a conference in

Paris on Thursday night at which she would like to raise the

possibility of a connection.

>

> Please forward this request to other email groups who might have

the answer or any useful ideas.

>

>

>

> I need to get back to her by Thursday latest.

>

> Hopefully, Alison

>