Vitamin D, the antioxidant

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COMPARATIVE EFFECTIVENESS OF VITAMIN D3 AND DIETARY VITAMIN E ON

PEROXIDATION OF LIPIDS AND ENZYMES OF THE HEPATIC ANTIOXIDANT

SYSTEM IN SPRAGUE - DAWLEY RATS

Sutapa Sardar, Anindita Chakraborty and Malay Chatterjee Division

of Biochemistry, Department of Pharmaceutical Technology,

Jadavpur University, P.O. Box No. 17028, Calcutta - 700 032, India.

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

1, 1996, p. 39-45 © Verlag Hans Huber AG, Bern

Summary

The vitamin D - endocrine system has mostly been studied for its

role in calcium and phosphorus metabolism and its possible role

as an antioxidant has been neglected. This study attempts to

elucidate the antioxidative properties of the prohormone with

respect to vitamin E, a membrane antioxidant. Results herein show

that D3 treatment brought about similar reduction in the extent of

lipid peroxidation and induction in superoxide dismutase (SOD)

activity, as with vitamin E supplementation. While selenium

dependent glutathione peroxidase (Se-dep. GPx) activity reflected

no change with vitamin D3 treatment, total GPx activity was more

significantly influenced by vitamin D3 than by vitamin E. The

glutathione (GSH) content in the experimental rats also reflected

similar changes. Vitamin E supplementation caused 8.57% increase

in glutathione reductase (GR) activity, while vitamin D3 decreased

the concerned enzymes activity by 11.11%. Vitamin D3 treatment

also caused 25% increase in glucose 6-phosphate dehydrogenase

(G6PD) activity. These data thus suggest that vitamin D3 may

function as an antioxidant in the liver in vivo and illustrate

an effectiveness higher than that observed with vitamin E

supplementation.

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