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I have been on 400 mg since January. I take both tablets ( 200 each) in

the morning soon as I wake. I find that my stomach is most empty then,

and by the time I get up, shower, ready for work, then an hour has

passed and I can have the coffee and breakfast without any hesitation.

It really works for me. Like Matt, can have a glass of wine on tasigna.

We do want to watch the AST/ALT counts for liver because tasigna tends

to run them high and the wine or alcolol wouldn't help with that!

I also find I can be in the sun a little without burning, and I have a

healthy look now rather than the gleevec transparent skin!

In all, I think you will find this drug to be THE best solution all the

way around. I am absolutelyelated on it.

Be well,

Barb

Barb Stanley 57 DX 5-5-2002 age 51 Hydroxurea 5-5-02-6-3--02

Gleevec 400 mg 6-11-02 MMR 8-1-02 CCR 12-10-02 PCRU 3-17-03 Gleevec

break: Feb. 15 - May 1-2007 (severe side effects) Gleevec 300 mg. May 1

- Dec. 15- 2007 800 mg tasigna Dec. 27 -Jan 12 ( stopped because of

side effects) 400 mg tasigna Jan 20 - present (NO SIDE EFFECTS)

Continuing strong PCRU

>

> Thanks Matt. I'll just keep crossing my fingers that no side effects

pop up!

>

>

>

>

> Regards,

>

>

>

> from Down Under

>

>

>

>

>

> From: [mailto: ] On Behalf Of

> mtmaynor@...

> Sent: Wednesday, 6 August 2008 11:22 PM

>

> Subject: Re: [ ] tasigna

>

>

>

> :

>

> If I eat and then take Tasigna, then I feel

> as if my body is struggling to process it,

> if that makes sense. I can just tell that

> I am not feeling right and it takes some

> time to get rid of that feeling.

>

> Yes, QT Prolongation is the biggest

> concern and that is why you need

> weekly EKG's done for your first

> month on the drug.

>

> Over time, you body will adjust and

> you will be better than ever. Just

> wait, you will see.

>

> Matt

>

>

>

>

>

> In a message dated 8/6/2008 8:53:54 A.M. Eastern Daylight Time,

> rodorbal@... <mailto:rodorbal%40westvic.com.au> writes:

>

> Hi Matt - thanks for the info, it is always good to get it first hand

so to

> speak. I know that if you have food with Tasigna is a definite no no

due to

> as you say, taking with food increases the absorption. I have a large

glass

> of water with the capsule, so at least have a drink after 2 hours

fasting.

>

> It's interesting with Glivec, that I never had a problem drinking

alcohol

> with it and with Tasigna have only had 1 glass of wine so far, as with

the

> cold I haven't felt like anything much. I hate grapefruit and it's

juice, so

> no problem and never taken St s Wart. My haem't passed on all the

info

> that Novartis sent him re contra indications, possible adverse effects

etc

> as I am his first patient on Tasigna, so we will be learning together.

It's

> great to have " thin " ankles again and eyes I can see out of! I was

doing

> well on Glivec 200mg, but as I have only just had my first CML

anniversary,

> it was felt it was too risky to continue on at this stage and I also

had a

> low serum level.

>

> I am still taking my magnesium tablets as I know this can also be a

problem

> with Tasigna. I have been on this drug 10 days now and it is a joy

compared

> to Glivec and I have been able to stop taking diuretics and other

medication

> I was taking for the migraines I was experiencing.

>

> Dr Tim our leading CML specialist told me that if you were to

eat a

> fatty meal without fasting on Tasigna, that possible side effects

could

> affect the heart (QT prolongation)affect the heart (QT

prolongation)<WB

> experience issues with pancreas and rises in serum amylase, lipase

etc. I

> had a base line ECG and that was fine and my haem't is monitoring that

> closely.

>

> When you say " I can tell if I eat and then take Tasigna that it is

more

> potent, but not as much afterward " , what sort of side effects do you

get?

>

> Regards,

>

> from Downunder

>

> From: _@... <mailto:_%40groups.CML> _

> (mailto: <mailto:%40> )

> [mailto:_@... <mailto:_%40groups.CML> _

> (mailto: <mailto:%40> ) ] On

Behalf

> Of

> _mtmaynor@... <mailto:_mtmaynor%40aol.mtm> _ (mailto:mtmaynor@...

> <mailto:mtmaynor%40aol.com> )

> Sent: Wednesday, 6 August 2008 10:09 PM

> _@... <mailto:_%40groups.CML> _

> (mailto: <mailto:%40> )

> Subject: Re: [ ] tasigna

>

> :

>

> Regarding your Tasigna question.

>

> According to my oncologist, they want you to have an

> empty stomach, so liquids or solids are supposed to

> be kept to a minimum. It has to do with the absorption

> and efficacy in your system, from what I understand. A

> full stomach increases the potency and thus can trigger

> heart or organ issues. For me, it seems that the no food

> two hours before is the most important. I can tell if I eat

> and then take Tasigna that it is more potent, but not as

> much afterward. Just like Gleevec, you will find the things

> that work and do not work for you. The standard things to

> watch on Gleevec, you also need to watch on Tasigna

> including Tylenol, St. s Wart and Grapefruit Juice, to

> name just a few.

>

> A lot of people find, especially after loose stools from

> Gleevec, that they have constipation (a shock to your

> system, especially if you have been on Gleevec for

> several years) so I take my doses with a half of a glass

> of Metamucil and I have no problems. Another thing to

> watch out for is middle back pain. This may be a sign

> of high Lipase, which is a concern of toxicity in your

> pancreas, which I experienced early on as I made the

> adjustment. You should call your Oncologist if this occurs.

>

> One thing that I found on Tasigna was that I could drink,

> which I really could not on Gleevec. So maybe you have

> that to look forward to.

>

> I hope Tasigna works well for you.

>

> Matt

> Florida CML Army

> Zero Club Number Misplaced

>

> In a message dated 8/6/2008 4:55:44 A.M. Eastern Daylight Time,

> _rodorbal@... <mailto:_rodorbal%40westvic.rodorb> _

> (mailto:rodorbal@... <mailto:rodorbal%40westvic.com.au> )

> <mailto:rodorbal%mailto:rodmailto> writes:

>

> Hi everyone,

>

> I commenced Tasigna last week - 400mg once a day and will commence

200mg

> tonight, working my way up to 400mg. After the very unlovely side

effects of

> Glivec, I am hesitant about going up to " full " strength without a lead

in

> and my haem/t has been very supportive of this.

>

> So far I have tolerated 400mg with no problems, except that I have the

worse

> head cold I have had in years, which was developing before I started

taking

> Tasigna.

>

> Just a question for the more experienced - when fasting at night, can

you

> still have water? I hate to think what it will be like come summer if

I

> can't have any water for 3 hours!

>

> I was going to start last night, then forgot to take the capsule at

7pm, so

> as we had family around to celebrate my daughter's birthday, I didn't

take

> it last night. I can see I am going to need to be very disciplined,

which I

> am not as I would often forget to take my Glivec at teatime and take

later

> in the night.

>

> Regards,

>

> from Down Under

>

> Rodorbal Labradors Australia

>

> <__http://www.rodorbalhttp:_ (http://www.rodorbalhttp_/)

> (_http://www.rodorbalhttp:_ (http://www.rodorbal.com/) ) >

www.rodorbal.

>

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