more evidence grape seed extract lowers BP

[Guest guest]

Hi all,

To me this is very significant news, especially considering I started

CRONing to lower my BP in the first place. Have been half-heartedly

taking grape seed extract or Pycnogenol on and off in the past already

for my BP, but reading about this study encourages me to take it

regularly. Anyone experienced lower average BP after taking this

supplement?

New human clinical trial study from UC :

" . . . .groups receiving grape seed extract experienced an equal

degree of reduced blood pressure. The average drop in systolic

pressure was 12 mm Hg. The average drop in diastolic pressure was

eight mm Hg "

Regards, Dave

Link:

http://www.nutraingredients-usa.com/news/ng.asp?n=66704 & m=1NIU328 & c=lqeudkujayvv\

lpc

full text:

Grape seed extract may help lower blood pressure

3/28/2006- A daily supplement of grape seed extract, a rich source of

polyphenols, could lower blood pressure and ease the burden of

metabolic syndrome, says new research.

Scientists from the University of California, , carried out the

first human clinical trial of grape seed extract with people suffering

from metabolic syndrome (MetS), a condition that affects an estimated

40 per cent of the US adult population.

MetS is a condition characterised by central obesity, hypertension,

and disturbed glucose and insulin metabolism. The syndrome has been

linked to increased risks of both type 2 diabetes and CVD.

The new research, presented at last weekend's American Chemical

Society Meeting and Exposition in Atlanta, divided 20 male and female

volunteers with diagnosed MetS into three groups, and supplemented

their normal diets with a placebo, or grape seed extracts with 150 or

300 milligrams of extract.

After one month, all participants taking the supplements had a

significant decrease in both systolic and diastolic blood pressure.

" Participants in the two groups receiving grape seed extract

experienced an equal degree of reduced blood pressure. The average

drop in systolic pressure was 12 mm Hg. The average drop in diastolic

pressure was eight mm Hg, " said lead author Tissa Kappagoda.

While both extracts produced similar decreases in blood pressure, the

scientists observed that the 300 mg extract also reduced blood levels

of oxidised LDL-cholesterol, which ahs been linked to an increased

risk of heart disease by a variety of experimental, genetic and

epidemiological studies.

" Generally, the higher the initial oxidised LDL level was, the greater

the drop by the end of the study, " said Kappagoda.

Grape seed extracts are rich sources of antioxidants such as catechins

and flavan-3-ols, and subsequent dimmers, trimers, and tetramers.

These polyphenols compounds are found in highest concentrations in the

seed of grapes, which can contain as much as eight per cent

polyphenols by weight.

The proposed mechanism of antioxidant activity of grape seed extract

involves intercepting the damaging free radicals that are produced by

oxidation of LDL-cholesterol.

The extracts, supplied by Polyphenolics, a division of Constellation

Wines US, who also funded the study, have already received the

generally recognised as safe (GRAS) certification from the FDA.

The news comes hot-on-the-heels of similar positive results for grape

seed extracts, with Masquelier's Original OPCs (oligomeric

proanythocyanidins), Anthogenol, being reported to reduce free radical

damage of endothelial cells (cells that line the wall of blood vessels).

Recent ex vivo experiments by Japanese researchers reported that

Anthogenol reduced oxidative stress of cell cultures by 60 per cent.

[Guest guest]

Hi folks:

Does anyone have information whether there is danger for people with

already very healthy blood pressure readings (such as the subjects in

the WUSTL study, for example) if they also take a bunch of 'food'

substances that may further reduce their BP? Grape seed extract is

one example. Cinnamon is another.

IOW, can one create a dangerously low level of BP if already CRONing

and takes some of these substances in addition?

Rodney.

>

> Hi all,

>

> To me this is very significant news, especially considering I

started

> CRONing to lower my BP in the first place. Have been half-heartedly

> taking grape seed extract or Pycnogenol on and off in the past

already

> for my BP, but reading about this study encourages me to take it

> regularly. Anyone experienced lower average BP after taking this

> supplement?

>

> New human clinical trial study from UC :

>

> " . . . .groups receiving grape seed extract experienced an equal

> degree of reduced blood pressure. The average drop in systolic

> pressure was 12 mm Hg. The average drop in diastolic pressure was

> eight mm Hg "

>

> Regards, Dave

>

>

> Link:

>

> http://www.nutraingredients-usa.com/news/ng.asp?

n=66704 & m=1NIU328 & c=lqeudkujayvvlpc

>

> full text:

>

> Grape seed extract may help lower blood pressure

>

> 3/28/2006- A daily supplement of grape seed extract, a rich source

of

> polyphenols, could lower blood pressure and ease the burden of

> metabolic syndrome, says new research.

>

> Scientists from the University of California, , carried out the

> first human clinical trial of grape seed extract with people

suffering

> from metabolic syndrome (MetS), a condition that affects an

estimated

> 40 per cent of the US adult population.

>

> MetS is a condition characterised by central obesity, hypertension,

> and disturbed glucose and insulin metabolism. The syndrome has been

> linked to increased risks of both type 2 diabetes and CVD.

>

> The new research, presented at last weekend's American Chemical

> Society Meeting and Exposition in Atlanta, divided 20 male and

female

> volunteers with diagnosed MetS into three groups, and supplemented

> their normal diets with a placebo, or grape seed extracts with 150

or

> 300 milligrams of extract.

>

> After one month, all participants taking the supplements had a

> significant decrease in both systolic and diastolic blood pressure.

>

> " Participants in the two groups receiving grape seed extract

> experienced an equal degree of reduced blood pressure. The average

> drop in systolic pressure was 12 mm Hg. The average drop in

diastolic

> pressure was eight mm Hg, " said lead author Tissa Kappagoda.

>

> While both extracts produced similar decreases in blood pressure,

the

> scientists observed that the 300 mg extract also reduced blood

levels

> of oxidised LDL-cholesterol, which ahs been linked to an increased

> risk of heart disease by a variety of experimental, genetic and

> epidemiological studies.

>

> " Generally, the higher the initial oxidised LDL level was, the

greater

> the drop by the end of the study, " said Kappagoda.

>

> Grape seed extracts are rich sources of antioxidants such as

catechins

> and flavan-3-ols, and subsequent dimmers, trimers, and tetramers.

> These polyphenols compounds are found in highest concentrations in

the

> seed of grapes, which can contain as much as eight per cent

> polyphenols by weight.

>

> The proposed mechanism of antioxidant activity of grape seed extract

> involves intercepting the damaging free radicals that are produced

by

> oxidation of LDL-cholesterol.

>

> The extracts, supplied by Polyphenolics, a division of Constellation

> Wines US, who also funded the study, have already received the

> generally recognised as safe (GRAS) certification from the FDA.

>

> The news comes hot-on-the-heels of similar positive results for

grape

> seed extracts, with Masquelier's Original OPCs (oligomeric

> proanythocyanidins), Anthogenol, being reported to reduce free

radical

> damage of endothelial cells (cells that line the wall of blood

vessels).

>

> Recent ex vivo experiments by Japanese researchers reported that

> Anthogenol reduced oxidative stress of cell cultures by 60 per cent.

>

[Guest guest]

Hi folks:

Does anyone have information whether there is danger for people with

already very healthy blood pressure readings (such as the subjects in

the WUSTL study, for example) if they also take a bunch of 'food'

substances that may further reduce their BP? Grape seed extract is

one example. Cinnamon is another.

IOW, can one create a dangerously low level of BP if already CRONing

and takes some of these substances in addition?

Rodney.

>

> Hi all,

>

> To me this is very significant news, especially considering I

started

> CRONing to lower my BP in the first place. Have been half-heartedly

> taking grape seed extract or Pycnogenol on and off in the past

already

> for my BP, but reading about this study encourages me to take it

> regularly. Anyone experienced lower average BP after taking this

> supplement?

>

> New human clinical trial study from UC :

>

> " . . . .groups receiving grape seed extract experienced an equal

> degree of reduced blood pressure. The average drop in systolic

> pressure was 12 mm Hg. The average drop in diastolic pressure was

> eight mm Hg "

>

> Regards, Dave

>

>

> Link:

>

> http://www.nutraingredients-usa.com/news/ng.asp?

n=66704 & m=1NIU328 & c=lqeudkujayvvlpc

>

> full text:

>

> Grape seed extract may help lower blood pressure

>

> 3/28/2006- A daily supplement of grape seed extract, a rich source

of

> polyphenols, could lower blood pressure and ease the burden of

> metabolic syndrome, says new research.

>

> Scientists from the University of California, , carried out the

> first human clinical trial of grape seed extract with people

suffering

> from metabolic syndrome (MetS), a condition that affects an

estimated

> 40 per cent of the US adult population.

>

> MetS is a condition characterised by central obesity, hypertension,

> and disturbed glucose and insulin metabolism. The syndrome has been

> linked to increased risks of both type 2 diabetes and CVD.

>

> The new research, presented at last weekend's American Chemical

> Society Meeting and Exposition in Atlanta, divided 20 male and

female

> volunteers with diagnosed MetS into three groups, and supplemented

> their normal diets with a placebo, or grape seed extracts with 150

or

> 300 milligrams of extract.

>

> After one month, all participants taking the supplements had a

> significant decrease in both systolic and diastolic blood pressure.

>

> " Participants in the two groups receiving grape seed extract

> experienced an equal degree of reduced blood pressure. The average

> drop in systolic pressure was 12 mm Hg. The average drop in

diastolic

> pressure was eight mm Hg, " said lead author Tissa Kappagoda.

>

> While both extracts produced similar decreases in blood pressure,

the

> scientists observed that the 300 mg extract also reduced blood

levels

> of oxidised LDL-cholesterol, which ahs been linked to an increased

> risk of heart disease by a variety of experimental, genetic and

> epidemiological studies.

>

> " Generally, the higher the initial oxidised LDL level was, the

greater

> the drop by the end of the study, " said Kappagoda.

>

> Grape seed extracts are rich sources of antioxidants such as

catechins

> and flavan-3-ols, and subsequent dimmers, trimers, and tetramers.

> These polyphenols compounds are found in highest concentrations in

the

> seed of grapes, which can contain as much as eight per cent

> polyphenols by weight.

>

> The proposed mechanism of antioxidant activity of grape seed extract

> involves intercepting the damaging free radicals that are produced

by

> oxidation of LDL-cholesterol.

>

> The extracts, supplied by Polyphenolics, a division of Constellation

> Wines US, who also funded the study, have already received the

> generally recognised as safe (GRAS) certification from the FDA.

>

> The news comes hot-on-the-heels of similar positive results for

grape

> seed extracts, with Masquelier's Original OPCs (oligomeric

> proanythocyanidins), Anthogenol, being reported to reduce free

radical

> damage of endothelial cells (cells that line the wall of blood

vessels).

>

> Recent ex vivo experiments by Japanese researchers reported that

> Anthogenol reduced oxidative stress of cell cultures by 60 per cent.

>

[Guest guest]

Hi folks:

IOW, do we know if the relationship between risk and BP is a straight

line or a 'U-curve'? And if the latter, how low is too low?

Rodney.

> >

> > Hi all,

> >

> > To me this is very significant news, especially considering I

> started

> > CRONing to lower my BP in the first place. Have been half-

heartedly

> > taking grape seed extract or Pycnogenol on and off in the past

> already

> > for my BP, but reading about this study encourages me to take it

> > regularly. Anyone experienced lower average BP after taking this

> > supplement?

> >

> > New human clinical trial study from UC :

> >

> > " . . . .groups receiving grape seed extract experienced an equal

> > degree of reduced blood pressure. The average drop in systolic

> > pressure was 12 mm Hg. The average drop in diastolic pressure was

> > eight mm Hg "

> >

> > Regards, Dave

> >

> >

> > Link:

> >

> > http://www.nutraingredients-usa.com/news/ng.asp?

> n=66704 & m=1NIU328 & c=lqeudkujayvvlpc

> >

> > full text:

> >

> > Grape seed extract may help lower blood pressure

> >

> > 3/28/2006- A daily supplement of grape seed extract, a rich

source

> of

> > polyphenols, could lower blood pressure and ease the burden of

> > metabolic syndrome, says new research.

> >

> > Scientists from the University of California, , carried out

the

> > first human clinical trial of grape seed extract with people

> suffering

> > from metabolic syndrome (MetS), a condition that affects an

> estimated

> > 40 per cent of the US adult population.

> >

> > MetS is a condition characterised by central obesity,

hypertension,

> > and disturbed glucose and insulin metabolism. The syndrome has

been

> > linked to increased risks of both type 2 diabetes and CVD.

> >

> > The new research, presented at last weekend's American Chemical

> > Society Meeting and Exposition in Atlanta, divided 20 male and

> female

> > volunteers with diagnosed MetS into three groups, and supplemented

> > their normal diets with a placebo, or grape seed extracts with

150

> or

> > 300 milligrams of extract.

> >

> > After one month, all participants taking the supplements had a

> > significant decrease in both systolic and diastolic blood

pressure.

> >

> > " Participants in the two groups receiving grape seed extract

> > experienced an equal degree of reduced blood pressure. The average

> > drop in systolic pressure was 12 mm Hg. The average drop in

> diastolic

> > pressure was eight mm Hg, " said lead author Tissa Kappagoda.

> >

> > While both extracts produced similar decreases in blood pressure,

> the

> > scientists observed that the 300 mg extract also reduced blood

> levels

> > of oxidised LDL-cholesterol, which ahs been linked to an increased

> > risk of heart disease by a variety of experimental, genetic and

> > epidemiological studies.

> >

> > " Generally, the higher the initial oxidised LDL level was, the

> greater

> > the drop by the end of the study, " said Kappagoda.

> >

> > Grape seed extracts are rich sources of antioxidants such as

> catechins

> > and flavan-3-ols, and subsequent dimmers, trimers, and tetramers.

> > These polyphenols compounds are found in highest concentrations

in

> the

> > seed of grapes, which can contain as much as eight per cent

> > polyphenols by weight.

> >

> > The proposed mechanism of antioxidant activity of grape seed

extract

> > involves intercepting the damaging free radicals that are

produced

> by

> > oxidation of LDL-cholesterol.

> >

> > The extracts, supplied by Polyphenolics, a division of

Constellation

> > Wines US, who also funded the study, have already received the

> > generally recognised as safe (GRAS) certification from the FDA.

> >

> > The news comes hot-on-the-heels of similar positive results for

> grape

> > seed extracts, with Masquelier's Original OPCs (oligomeric

> > proanythocyanidins), Anthogenol, being reported to reduce free

> radical

> > damage of endothelial cells (cells that line the wall of blood

> vessels).

> >

> > Recent ex vivo experiments by Japanese researchers reported that

> > Anthogenol reduced oxidative stress of cell cultures by 60 per

cent.

> >

>

[Guest guest]

Hi folks:

IOW, do we know if the relationship between risk and BP is a straight

line or a 'U-curve'? And if the latter, how low is too low?

Rodney.

> >

> > Hi all,

> >

> > To me this is very significant news, especially considering I

> started

> > CRONing to lower my BP in the first place. Have been half-

heartedly

> > taking grape seed extract or Pycnogenol on and off in the past

> already

> > for my BP, but reading about this study encourages me to take it

> > regularly. Anyone experienced lower average BP after taking this

> > supplement?

> >

> > New human clinical trial study from UC :

> >

> > " . . . .groups receiving grape seed extract experienced an equal

> > degree of reduced blood pressure. The average drop in systolic

> > pressure was 12 mm Hg. The average drop in diastolic pressure was

> > eight mm Hg "

> >

> > Regards, Dave

> >

> >

> > Link:

> >

> > http://www.nutraingredients-usa.com/news/ng.asp?

> n=66704 & m=1NIU328 & c=lqeudkujayvvlpc

> >

> > full text:

> >

> > Grape seed extract may help lower blood pressure

> >

> > 3/28/2006- A daily supplement of grape seed extract, a rich

source

> of

> > polyphenols, could lower blood pressure and ease the burden of

> > metabolic syndrome, says new research.

> >

> > Scientists from the University of California, , carried out

the

> > first human clinical trial of grape seed extract with people

> suffering

> > from metabolic syndrome (MetS), a condition that affects an

> estimated

> > 40 per cent of the US adult population.

> >

> > MetS is a condition characterised by central obesity,

hypertension,

> > and disturbed glucose and insulin metabolism. The syndrome has

been

> > linked to increased risks of both type 2 diabetes and CVD.

> >

> > The new research, presented at last weekend's American Chemical

> > Society Meeting and Exposition in Atlanta, divided 20 male and

> female

> > volunteers with diagnosed MetS into three groups, and supplemented

> > their normal diets with a placebo, or grape seed extracts with

150

> or

> > 300 milligrams of extract.

> >

> > After one month, all participants taking the supplements had a

> > significant decrease in both systolic and diastolic blood

pressure.

> >

> > " Participants in the two groups receiving grape seed extract

> > experienced an equal degree of reduced blood pressure. The average

> > drop in systolic pressure was 12 mm Hg. The average drop in

> diastolic

> > pressure was eight mm Hg, " said lead author Tissa Kappagoda.

> >

> > While both extracts produced similar decreases in blood pressure,

> the

> > scientists observed that the 300 mg extract also reduced blood

> levels

> > of oxidised LDL-cholesterol, which ahs been linked to an increased

> > risk of heart disease by a variety of experimental, genetic and

> > epidemiological studies.

> >

> > " Generally, the higher the initial oxidised LDL level was, the

> greater

> > the drop by the end of the study, " said Kappagoda.

> >

> > Grape seed extracts are rich sources of antioxidants such as

> catechins

> > and flavan-3-ols, and subsequent dimmers, trimers, and tetramers.

> > These polyphenols compounds are found in highest concentrations

in

> the

> > seed of grapes, which can contain as much as eight per cent

> > polyphenols by weight.

> >

> > The proposed mechanism of antioxidant activity of grape seed

extract

> > involves intercepting the damaging free radicals that are

produced

> by

> > oxidation of LDL-cholesterol.

> >

> > The extracts, supplied by Polyphenolics, a division of

Constellation

> > Wines US, who also funded the study, have already received the

> > generally recognised as safe (GRAS) certification from the FDA.

> >

> > The news comes hot-on-the-heels of similar positive results for

> grape

> > seed extracts, with Masquelier's Original OPCs (oligomeric

> > proanythocyanidins), Anthogenol, being reported to reduce free

> radical

> > damage of endothelial cells (cells that line the wall of blood

> vessels).

> >

> > Recent ex vivo experiments by Japanese researchers reported that

> > Anthogenol reduced oxidative stress of cell cultures by 60 per

cent.

> >

>

[Guest guest]

Rod: cinnamon lowers blood sugar not pressure. If it lowers BP, then please someone post the evidence.

on 3/29/2006 12:27 PM, Rodney at perspect1111@... wrote:

Hi folks:

Does anyone have information whether there is danger for people with

already very healthy blood pressure readings (such as the subjects in

the WUSTL study, for example) if they also take a bunch of 'food'

substances that may further reduce their BP? Grape seed extract is

one example. Cinnamon is another.

IOW, can one create a dangerously low level of BP if already CRONing

and takes some of these substances in addition?

Rodney.

[Guest guest]

Rod: cinnamon lowers blood sugar not pressure. If it lowers BP, then please someone post the evidence.

on 3/29/2006 12:27 PM, Rodney at perspect1111@... wrote:

Hi folks:

Does anyone have information whether there is danger for people with

already very healthy blood pressure readings (such as the subjects in

the WUSTL study, for example) if they also take a bunch of 'food'

substances that may further reduce their BP? Grape seed extract is

one example. Cinnamon is another.

IOW, can one create a dangerously low level of BP if already CRONing

and takes some of these substances in addition?

Rodney.

[Guest guest]

Hi Francesca:

Funny you should mention that. Thanks. I just got a reply today

from a source I had questioned about this and they have promised to

send their source - apparently in a study that was also assessing the

effects of cinnamon on diabetics.

But I have not been able to find such a source independently.

If they supply the source I will post it.

Rodney.

>

> Hi folks:

>

> Does anyone have information whether there is danger for people with

> already very healthy blood pressure readings (such as the subjects

in

> the WUSTL study, for example) if they also take a bunch of 'food'

> substances that may further reduce their BP? Grape seed extract is

> one example. Cinnamon is another.

>

> IOW, can one create a dangerously low level of BP if already CRONing

> and takes some of these substances in addition?

>

> Rodney.

>

[Guest guest]

Hi,

I found this study that seams to support the idea that cinamon help

with lowering blood pressure.

http://www.jacn.org/cgi/content/abstract/25/2/144

Regards,

Nuno

> >

> > Hi folks:

> >

> > Does anyone have information whether there is danger for people with

> > already very healthy blood pressure readings (such as the subjects

> in

> > the WUSTL study, for example) if they also take a bunch of 'food'

> > substances that may further reduce their BP? Grape seed extract is

> > one example. Cinnamon is another.

> >

> > IOW, can one create a dangerously low level of BP if already CRONing

> > and takes some of these substances in addition?

> >

> > Rodney.

> >

>