Re: Parkinsonism--an analog?

[Guest guest]

Hi ,

I find your comments very interesting, not least as my mother-in-law has

PD and we often compare notes which turn out to be very similar in many

instances eg; that 'fizzing' electrical 'stiff' feeling that I certainly

get as does she.

Rosie

Looking at Parkinson's Disease info got me thinking that maybe

Parkinson's

(also an SNP-linked condition, BTW) is, like Autism, a specific analog

to

the underlying type of dysfunction found in CFS. It's a conjecture

strengthened by recent apparent successes in CFS with dopamine boosters.

What really got my attention though, is that the impaired part of the

brain

in PD, the substantia nigra, is among the basal ganglia, and they have

shown

a hypoperfusion of blood in CFIDS, no?. And depression does not show a

hypoperfusion there--is that right??

Among the three neurological impairments of PD, there is one I feel I

have

in spades. Described in one article, like this: " Bradykinesia...is a

difficulty INITIATING VOLUNTARY MOVEMENT, as though the brake cannot be

released. "

Maybe we lack the effective preparatory pre-picturing of actions, which

is

dependent on the basal ganglia, and is required before an action can be

externalized in the body.

To me, it is not so much like the _brake_ being set as like the _clutch_

being disengaged. I think this may be the " staring " state PWCs have

described (like I'm sitting _way_ back inside my body, looking out

through

the wrong end of a telescope, and to come all the way forward and do

something is unimaginable.

This immobilization is on top off the mitochondrial fatigue, or it could

be

a defense against pre-picturing things the mitochondria are not equipped

to

enact. Anyhow, it is a different kind of immobilization, which is widely

misunderstood, even by ourselves sometimes, when characterized simply as

fatigue.

--

[Guest guest]

" Kolodney " <d4235@...> wrote:

> Among the three neurological impairments of PD, there is one I feel

I have in spades. Described in one article, like

this: " Bradykinesia...is a difficulty INITIATING VOLUNTARY MOVEMENT,

as though the brake cannot be released. "

> This immobilization is on top off the mitochondrial fatigue, or it

could be a defense against pre-picturing things the mitochondria are

not equipped to enact. Anyhow, it is a different kind of

immobilization, which is widely misunderstood, even by ourselves

sometimes, when characterized simply as fatigue.

>

> --

Terrific description!

-

[Guest guest]

Interesting...my father has Parkinson's Disease, and he was told he

had hypoperfusion in the brain..

My mother had extremely severe Rhuematoid Arthritis/Vasculitis..there

seemed to be a connection, there, as well, to our diseases.

What symptoms have been relieved with Dopamine Boosting?

>

> Looking at Parkinson's Disease info got me thinking that maybe

Parkinson's

> (also an SNP-linked condition, BTW) is, like Autism, a specific

analog to

> the underlying type of dysfunction found in CFS. It's a conjecture

> strengthened by recent apparent successes in CFS with dopamine

boosters.

>

> What really got my attention though, is that the impaired part of

the brain

> in PD, the substantia nigra, is among the basal ganglia, and they

have shown

> a hypoperfusion of blood in CFIDS, no?. And depression does not

show a

> hypoperfusion there--is that right??

>

> Among the three neurological impairments of PD, there is one I feel

I have

> in spades. Described in one article, like this: " Bradykinesia...is a

> difficulty INITIATING VOLUNTARY MOVEMENT, as though the brake

cannot be

> released. "

>

> Maybe we lack the effective preparatory pre-picturing of actions,

which is

> dependent on the basal ganglia, and is required before an action

can be

> externalized in the body.

> To me, it is not so much like the _brake_ being set as like the

_clutch_

> being disengaged. I think this may be the " staring " state PWCs have

> described (like I'm sitting _way_ back inside my body, looking out

through

> the wrong end of a telescope, and to come all the way forward and do

> something is unimaginable.

>

> This immobilization is on top off the mitochondrial fatigue, or it

could be

> a defense against pre-picturing things the mitochondria are not

equipped to

> enact. Anyhow, it is a different kind of immobilization, which is

widely

> misunderstood, even by ourselves sometimes, when characterized

simply as

> fatigue.

>

> --

>

[Guest guest]

Posted by: " lifelonglearner79 "

>>What symptoms have been relieved with Dopamine Boosting?

Good call! I don't know why I stated that " boosting " idea so flatly. I was

still in the context of the message from Janice I had responded to the day

before, which suggested the benefit of dopamine as a " proposed hypothesis, "

so in my response to _that_ it was a " given. "

I really don't have a lot to go on. Janice's report. My own positive

experience with Wellbutrin and policosanol. This message from

" davidhall2020 "

" Check out message# 110561. Also, Dr Yasko thinks dopamine is disrupted and

important to the pathology of autism, CFS and several other conditions with

similar features, FWIW. " And in his earlier message 110561, " Dopamine is

often low in PWCs on neurotransmitter tests along with GABA. "

So, nothing you could call " success stories, " (although I did!).

Leaving all that behind, I did find what might be a suggestion of common

mechanisms in CFIDS and Parkinson's, in relation to hypoperfusion in the

brain stem, though I may well be reading it wrong.

We have this in the archive:

From: " Lance " <alancemor@...>

Subject: Brain hypoperfusion causal theories?

Date: Fri, 22 Aug 2003 16:53:19 -0000

" Some/many of us have abnormal brain SPECT/PETs, usually asymmetric

hypoperfusion affecting localized areas - lobes and/or brain stem (vs.

depression's more symmetric and global hypoperfusion). "

And this from Google:

" Akinesia is the most disabling symptom of Parkinson's disease. The neural

mechanisms underlying it probably involve the descending projections of the

basal ganglia to the brain stem... "

http://cat.inist.fr/?aModele=afficheN & cpsidt=2295183

--

[Guest guest]

Wow! O boy!

I had never heard that described before. I have been at a loss for so long about

that. Not only is it weird, but it is as coming-and-going a symptom as many

others are. Boy: a flood of emotion. How scary a thing it is, how confusing.

A clue. Caffeine takes it right away. ('Course I cannot do caffeine on more than

a very occasional basis.)

Adrienne

Parkinsonism--an analog?

Looking at Parkinson's Disease info got me thinking that maybe Parkinson's

(also an SNP-linked condition, BTW) is, like Autism, a specific analog to

the underlying type of dysfunction found in CFS. It's a conjecture

strengthened by recent apparent successes in CFS with dopamine boosters.

What really got my attention though, is that the impaired part of the brain

in PD, the substantia nigra, is among the basal ganglia, and they have shown

a hypoperfusion of blood in CFIDS, no?. And depression does not show a

hypoperfusion there--is that right??

Among the three neurological impairments of PD, there is one I feel I have

in spades. Described in one article, like this: " Bradykinesia...is a

difficulty INITIATING VOLUNTARY MOVEMENT, as though the brake cannot be

released. "

Maybe we lack the effective preparatory pre-picturing of actions, which is

dependent on the basal ganglia, and is required before an action can be

externalized in the body.

To me, it is not so much like the _brake_ being set as like the _clutch_

being disengaged. I think this may be the " staring " state PWCs have

described (like I'm sitting _way_ back inside my body, looking out through

the wrong end of a telescope, and to come all the way forward and do

something is unimaginable.

This immobilization is on top off the mitochondrial fatigue, or it could be

a defense against pre-picturing things the mitochondria are not equipped to

enact. Anyhow, it is a different kind of immobilization, which is widely

misunderstood, even by ourselves sometimes, when characterized simply as

fatigue.

--

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.