A familiar polymorphism - 677C

[Guest guest]

This article is not new (August 2005) but my interest in MTHFR 677C is

new.

http://www.psychiatrictimes.com/showArticle.jhtml?articleID=170101200

" The most notable of these polymorphisms is the folate-sensitive

product of the 677C —>T methylenetetrahydrofolate gene variant, which

participates in the remethylation of homocysteine to methionine.

Presence of this gene variant results in elevated homocysteine in the

presence of low folate (Murakami et al., 2001). This elevated

homocysteine itself has modulatory effects at the N-methyl-D-aspartate

(NMDA) receptor, the central element in the glutamatergic theory of

schizophrenia (Kornhuber and Weller, 1997). "

Sue

Upstate New York