Re: inability to lose/gain weight with CFS/ME/FMS

[Guest guest]

Most people are malabsorbing so I guess this could be part of the cause ie

leaky gut issues.

Regards

CS

[Guest guest]

Hi, .

As far as I know, there are no published papers in the peer-reviewed

medical literature that deal with the subject of inability to lose

or gain weight in CFS. In my experience, there are more who have

difficulty losing weight than there are who have difficulty gaining

weight, though both subsets are present in the CFS population.

As I responded to you on the cfsfmresearch list, I believe that the

reason many are unable to lose weight is that they have low

metabolic rates, due to partial blockades in their mitochondria,

often due in turn to glutathione depletion and are thus not able to

burn carbohydrates or fats at normal rates. I have reprinted that

response below.

For those who are unable to gain weight, I believe that the problem

is malabsorption by the G.I. tract. Some PWCs have serious issues

in the function of their gut, and they are simply not able to absorb

enough nutrients from their food. Some report that inspection of

their stools reveals food that has hardly been changed from the way

it looked when it was eaten. In these cases, I think there are

major deficits in stomach acid production and in pancreatic

digestive juice production and supply to the duodenum, and that

these may be caused by serious mineral deficiencies, particularly in

magnesium and zinc. Some also have the diarrhea type of irritable

bowel syndrome, and I think this may involve too fast a transit of

food through the G.I. tract, so that digestion and absorption do not

have enough time to occur. Overproduction of serotonin in the gut

may be responsible for this, but I don't know what causes that.

Reprint of explanation for inability to lose weight from

cfsfmresearch list:

I think the explanation for this is that people with CFS tend to

have low metabolic rates, and thus their bodies do not burn food at

normal rates. Food therefore tends to be deposited as stored fat,

unless the intake is severely decreased. You can check this on

yourself by measuring your armpit temperature as soon as you wake up

in the morning, before you arise from bed. (Shake a thermometer

down the night before, and put it on your nightstand, so you can use

it in the morning before getting up and before doing any exercise.

Put it in an armpit for 10 minutes, with your arm held snugly

against your body. Do this for three days and average the results

together. If it comes out in the 96 degrees Fahrenheit range or

lower, your metabolic rate is low.

Some PWCs can raise their metabolic rate by taking thyroid hormone.

It's best to use Armour thyroid if you want to try this, because it

contains both T3 and T4, and some PWCs are not able to convert T4 to

T3.

Other PWCs cannot raise their metabolic rate to normal by taking

thyroid hormones. I think the reason why many cannot is that there

are partial blockades in the mitochondria of their cells. A

possible cause of this is glutathione depletion, which can allow

oxidizing free radicals to rise in concentration, and can also allow

toxins to build up. If you try thyroid hormone and it doesn't bring

your armpit temperature into the 98 Fahrenheit range, then the next

thing to do is to have your red blood cell glutathione measured by

http://www.immuno-sci-lab.com, which I think still costs $85. If it

comes out low, then the task is to build it up. I have posted

messages about this here in the past, and they are in the archives.

Note especially the one on autism and CFS and the one on glutathione

building.

For those in the U.K. especially, but it's also possible to do this

from the U.S. or other countries, you can send a blood sample to

http://www.biolab.co.uk for their ATP Profile. This test panel will

determine more specifically what's going on in your mitchondria.

They have also recently completed development on a test that will

determine which specific toxins are blocking the ATP-ADP Translocase

protein in the mitochondrial inner membrane, if that turns out to be

a problem, based on the ATP Profile.

Rich

>

> Hi

>

> I am seeking expert information such as articles in medical

journals;

> or quoteable statements from experts

> about the reasons why many people with ME/CFS/FMS are unable to

either

> lose or gain weight.

>

> I must stress that I am not looking for any kind of nutritional or

> dietary information.

>

> I heard a hint somewhere that interferences with hormones or

metabolic

> rate within ME/CFS/FMS;

> can cause either an inability to lose or gain weight, and I am

hoping

> that someone here can further enlighten me with some expert

> information; or point me in the direction of finding expert

information

> that I can pass on to my specialist.

>

> many thanks

>

[Guest guest]

thank you for your ideas

they may be useful if you can substantiate them?

or perhaps refer me to a source of medical information on the subject

that I can take to my specialist

thanks

thanks

>

>

>

> Most people are malabsorbing so I guess this could be part of the

cause ie

> leaky gut issues.

>

> Regards

> CS

>

>

>

>

>

[Guest guest]

thanks very much rich

I knew you had given me some information before but I when I searched

for it I couldnt find it again.

Its a shame that there seems to be nothing more substantial available

but this certainly better than nothing at all

thanks

> >

> > Hi

> >

> > I am seeking expert information such as articles in medical

> journals;

> > or quoteable statements from experts

> > about the reasons why many people with ME/CFS/FMS are unable to

> either

> > lose or gain weight.

> >

> > I must stress that I am not looking for any kind of nutritional

or

> > dietary information.

> >

> > I heard a hint somewhere that interferences with hormones or

> metabolic

> > rate within ME/CFS/FMS;

> > can cause either an inability to lose or gain weight, and I am

> hoping

> > that someone here can further enlighten me with some expert

> > information; or point me in the direction of finding expert

> information

> > that I can pass on to my specialist.

> >

> > many thanks

> >

>

[Guest guest]

>

> Hi, .

>

>

> For those in the U.K. especially, but it's also possible to do this

> from the U.S. or other countries, you can send a blood sample to

> http://www.biolab.co.uk for their ATP Profile. This test panel

will

> determine more specifically what's going on in your mitchondria.

> They have also recently completed development on a test that will

> determine which specific toxins are blocking the ATP-ADP

Translocase

> protein in the mitochondrial inner membrane, if that turns out to

be

> a problem, based on the ATP Profile.

>

> Rich

>

Hi Rich

As you might recall I had a partial blockage in the production of

ATP from ADP (not the translocator section, that was normal). Do

you know the name of the new test?

Thanks

Pam

[Guest guest]

Hi, Pam.

The test is called " Mitochondrial membrane--Translocator protein

[TL] " . Dr. wrote me that they have worked on the development

of this test for four years, and that they are now able to determine

the specific cause of blocks in the translocator site for 97% of the

cases that have such a block (which amounts to about 40% of those

who have an abnormal ATP Profile test). This test sounds very

impressive to me, and it specifically detects a variety of toxins,

including pesticides, toxic metals, chlorinated hydrocarbons, PBBs,

etc.

Rich

> >

> > Hi, .

> >

> >

> > For those in the U.K. especially, but it's also possible to do

this

> > from the U.S. or other countries, you can send a blood sample to

> > http://www.biolab.co.uk for their ATP Profile. This test panel

> will

> > determine more specifically what's going on in your mitchondria.

> > They have also recently completed development on a test that will

> > determine which specific toxins are blocking the ATP-ADP

> Translocase

> > protein in the mitochondrial inner membrane, if that turns out

to

> be

> > a problem, based on the ATP Profile.

> >

> > Rich

> >

> Hi Rich

>

> As you might recall I had a partial blockage in the production of

> ATP from ADP (not the translocator section, that was normal). Do

> you know the name of the new test?

>

> Thanks

> Pam

>

[Guest guest]

> >

> > Hi

> >

> > I am seeking expert information such as articles in medical

> journals;

> > or quoteable statements from experts

> > about the reasons why many people with ME/CFS/FMS are unable to

> either

> > lose or gain weight.

> >

> > I must stress that I am not looking for any kind of nutritional

or

> > dietary information.

> >

> > I heard a hint somewhere that interferences with hormones or

> metabolic

> > rate within ME/CFS/FMS;

> > can cause either an inability to lose or gain weight, and I am

> hoping

> > that someone here can further enlighten me with some expert

> > information; or point me in the direction of finding expert

> information

> > that I can pass on to my specialist.

> >

> > many thanks

> >

>

[Guest guest]

Hi Dianne,

I just wanted to comment, I don't know if you have a diagnosis of fibro or not,

but the pain in your feet thing sounds very familiar to me. It is definitely

one of my fibro symptoms. I cannot ever wear sandals that have those " massage

insoles " . They cause great pain. I even had to throw away a brand new pair of

socks this winter because they had nonskid bottoms and the little rubber pieces

caused me great pain with every step. If you aren't already aware, often CFS

and fibro do go together.

-Dawn...I have a lot of pain in my feet all the time more than > anywhere else

and I still get muscle fatigue....like what ever I do > whether walking or

lifting something on the heavy side I suffer not > just the next day but it

seems on going..like you just cannot > improve your strength whatever you do.

Because e-mail on your cell phone should be easy: Try Windows Live Mail for

Mobile beta

http://www2.imagine-msn.com/minisites/mail/Default.aspx?locale=en-us

[Guest guest]

>

> Hi Dianne,

>

> I just wanted to comment, I don't know if you have a diagnosis of

fibro or not, but the pain in your feet thing sounds very familiar

to me. It is definitely one of my fibro symptoms. I cannot ever

wear sandals that have those " massage insoles " . They cause great

pain. I even had to throw away a brand new pair of socks this

winter because they had nonskid bottoms and the little rubber pieces

caused me great pain with every step. If you aren't already aware,

often CFS and fibro do go together.

>

> -Dawn...I have a lot of pain in my feet all the time more than >

anywhere else and I still get muscle fatigue....like what ever I do

> whether walking or lifting something on the heavy side I suffer

not > just the next day but it seems on going..like you just cannot

> improve your strength whatever you do.

>

.........Hi Dawn,

The only through examination I had was Dec 05 and I only got

that because I went private...it felt like my time was running

out.. I chose an endo as my consultant physician, highly

recommended around here and allrounder. His conclusions where based

on Physcial examination at this stage..a functional disorder and/or

chronic fatigue syndrome,fibromyalgia possibility of Sjogrens or a

mixed connectivie-tissue disorder... he felt this was not endocrine

related(at that time my thyroid levels where reasonable and he would

have known that)But he was through and I was impressed with him...

I did have loads of bloodwork done and liver and kidney functions

where out of range but not enough for any comments from my GP who

was sympathic etc. etc....end of story Dr wise,end of me chasing

doctors wise or otherewise...pun intended. BW Dianne

>

>

> Because e-mail on your cell phone should be easy: Try Windows

Live Mail for Mobile beta

> http://www2.imagine-msn.com/minisites/mail/Default.aspx?locale=en-

us

>

>