Re: Does ibuprofen decrease glutathione and result in CFSer feeling worse?

[Guest guest]

,

Cheney pink lined me on Tylenol. That means, it is very important.

He wants me to take 350mg X 3/wk. He said this would influence

glutathione gene expression.

I am not doing it, because I don't feel as well doing it. I keep

thinking I should make a greater effort, but just haven't gotten

around to it.

Anyway, just FYI

Zippy

btw, THIS IS HOW YOU SEPERATE A MESSAGE JASON !!!

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-- In , jseaton357@a... wrote:

> Rich, does advil reduce glutathione? I know Tylenol does. I ask

b/c I

> injured my low back many weeks ago and when I returned to the back

doc a month

> later for checkup he told me just one advil morning and night can

reduce

> inflamation enough which promotes healing, and so I began taking

just that. I noticed

> maybe coincidence but I have not felt as well since then which is

the first

> time I stopped getting better on consistent basis. Not feeling

like crap, just

> not as good as 2 weeks ago is all. It's all good though b/c I was

hoping I'd

> not be as good as I was at my max couple weeks ago when I see Dr.

Shoemaker in

> a couple weeks as I don't want any test results to come out looking

like I'm

> running like a champ. In addition to this thinking, I also decided

not to do

> abx rotation this month for the first time since May as by the time

I finished

> my rotation of 10 days it would be only a few days before the visit

and I

> didn't want to chance say killing off any staph that need to show

up as normally

> there when he does his typical deep nasal culture for coag neg

staph, and I

> sure don't want to sway any cytokine or hormone results he may

measure as who

> knows what those abx are doing in addition to just assumably

killing bacteria.

> As I told another, I am not expecting Shoemaker to be able to help

me, but if

> he does then great. If not I'll continue to do what I'm doing and

try other

> things as I get more money. I'd like to try both Zhang's Herbs and

new Samento

> tincture from Allergy Research Group.

>

>

>

>

[Guest guest]

,

Ibuprofen is not detoxed from the body by conjugation with

glutathione, so it doesn't deplete glutathione in the way that

acetaminophen can. Ibuprofen is detoxed using a couple of the

cytochrome P450 enzymes in Phase 1, and glucuronidation in Phase 2

of detox.

This is not to say that ibuprofen can't produce other problems.

Rich

> Rich, does advil reduce glutathione? I know Tylenol does.

>