Re: ER episode last night!

[Guest guest]

Hi,

I saw that and my jaw dropped. Could not figure out where on earth they

got that from. The guy specifically said he inherited the Philadelphia

chromosome and it ran on his grandmother's side of the family. He said

he had it " from birth. " I had thought that ER actually had doctors on

staff to make sure the info was medically accurate, but clearly someone

goofed. I'm not even sure what the point of having that scene was, but

then, I did miss part of the show. It seemed gratuitous to me. I have

access to a subscription medical site that reviews each ER episode, so

I'll be interested to see what they have to say about this.

G.

Support the Leukemia Society with your donation:

www.upstairswindow.org

[ ] ER episode last night!

Did anyone see the ER episode last night? There was a patient who had

CML and he said that he inherited the Philidelphia Chromosome from his

mother. I have been told that it is not inherited!! Thought it was

interesting that they would say this!!

[Guest guest]

,

Let us know if you find anything!! I also thought they consulted with real

docs to make sure info. was accurate. I think the point of that clip had to do

with Abby. The whole episode showed little scenes with patients like that

because she was contemplating whether she was going to keep her baby (she is

pregnant). Of course, after that guy said he " inherited " this gene, she thought

well what if I pass on my family's " depression " to my baby, etc.

B

jennifer g <jenniferg@...> wrote:

Hi,

I saw that and my jaw dropped. Could not figure out where on earth they

got that from. The guy specifically said he inherited the Philadelphia

chromosome and it ran on his grandmother's side of the family. He said

he had it " from birth. " I had thought that ER actually had doctors on

staff to make sure the info was medically accurate, but clearly someone

goofed. I'm not even sure what the point of having that scene was, but

then, I did miss part of the show. It seemed gratuitous to me. I have

access to a subscription medical site that reviews each ER episode, so

I'll be interested to see what they have to say about this.

G.

Support the Leukemia Society with your donation:

www.upstairswindow.org

[ ] ER episode last night!

Did anyone see the ER episode last night? There was a patient who had

CML and he said that he inherited the Philidelphia Chromosome from his

mother. I have been told that it is not inherited!! Thought it was

interesting that they would say this!!

[Guest guest]

I was told t his summer by an old Amish doctor that cml in also

inherited he told me that I should have my girls checked out

periodically. I had an Aunt that passe away from myelofibrosis

which is an mpd so I don't know if that would have anything to do

with me?? Of course she was in her early 70's and I'm

37.

Sheila

In , " jennifer g " <jenniferg@c...> wrote:

>

> Hi,

>

> I saw that and my jaw dropped. Could not figure out where on earth

they

> got that from. The guy specifically said he inherited the

Philadelphia

> chromosome and it ran on his grandmother's side of the family. He

said

> he had it " from birth. " I had thought that ER actually had doctors

on

> staff to make sure the info was medically accurate, but clearly

someone

> goofed. I'm not even sure what the point of having that scene was,

but

> then, I did miss part of the show. It seemed gratuitous to me. I

have

> access to a subscription medical site that reviews each ER

episode, so

> I'll be interested to see what they have to say about this.

>

> G.

> Support the Leukemia Society with your donation:

> www.upstairswindow.org

>

>

>

> [ ] ER episode last night!

>

>

> Did anyone see the ER episode last night? There was a patient who

had

> CML and he said that he inherited the Philidelphia Chromosome from

his

> mother. I have been told that it is not inherited!! Thought it

was

> interesting that they would say this!!

>

>

>

>

>

>

[Guest guest]

At 07:36 PM 1/6/06 +0000, you wrote:

>I was told t his summer by an old Amish doctor that cml in also

>inherited he told me that I should have my girls checked out

>periodically. I had an Aunt that passe away from myelofibrosis

>which is an mpd so I don't know if that would have anything to do

>with me?? Of course she was in her early 70's and I'm

>37.

Hi Sheila,

I believe there is NO scientific evidence that CML is inherited. The

disease has been understood (since the 1960's) and there is no pattern of

inheritance. It is an acquired mutation.

That being said......people do inherit 'weaknesses' in their genetic

make-up....which could predispose someone to being more likely to develop

cancer, or a particular type of cancer, etc.

Do you know that there is a certain % of the population that is carrying

the ph+ chromosome at any given time that does not develop CML...this is

because their immune system recognizes the ph+ translocation as a defect

and eliminates it.......this did not happen for those of us who go on to

develop CML. (This might be because our ph+ mutation occurred in a primary

stem cell???....this is one theory).

Also, other leukemias are different....I don't believe their mechanism of

development is understood like CML....so to say that another relative had a

different kind of leukemia (such as CLL) also does not add to the theory of

it being inherited.

CML is probably one of the most studied and researched cancers...and the

consensus is that it is not inherited.

C.

[Guest guest]

Hello all

well when I was diagnosed with CML many moons ago, I

was told that it was my exposure to RF that cause my

problem.

That is low dose radiation. I forgot the year but in

a may issue of QST (Ham publication) they had many

studies listed to prove that radiation causes

cancers..

below are a few quotes from sources about the question

can it be passed on from one generation to the next

and it looks like no is the answer

1. Analysis of information on leukaemia incidence and

mortality following external exposure to low linear

energy transfer (LET) radiation concluded that the

incidence of acute leukaemias and chronic myeloid

leukaemia (CML) exhibits strong associations with

external low LET radiation exposure.

For chronic myelogenous leukemia (CML), a malignancy

of the hematopoietic stem cell characterized by the

Philadelphia chromosome and the hybrid BCR-ABL fusion

gene, epidemiologic studies have failed to find any

reproducible, significant association with either

genetic or environmental factors except for ionizing

radiation and benzene. In order to find new evidence

for the hypothesis that CML is a combined result of

environmental exposure and genetic susceptibility, we

used the polymerase chain reaction (PCR)-based

genotyping approach described by Krajinovic et al

Heredity or Genetic Factors

1. There are no clear hereditary factors associated

with CML. Identical twins of patients with CML are at

no greater risk of developing CML than other siblings.

This strongly suggests that environmental factors are

much more important than genetic factors in the

development of CML. It is a scientific mystery as to

why only one of a pair of identical twins will develop

CML, since the genetics are identical and

environmental exposures are similar, if not the same.

HLA is the histocompatibility system that is used to

match people for bone marrow, liver and kidney

transplants. One study has found that a specific HLA

type, DR4, is associated with a lower incidence of

CML, however researchers have not yet identified the

reason for this decrease.

--- jenniferabosse <jenniferabosse@...> wrote:

> Did anyone see the ER episode last night? There was

> a patient who had

> CML and he said that he inherited the Philidelphia

> Chromosome from his

> mother. I have been told that it is not inherited!!

> Thought it was

> interesting that they would say this!!

>

>

>

>

__________________________________________

DSL – Something to write home about.

Just $16.99/mo. or less.

dsl.

[Guest guest]

Skip, et. al.,

Just a final thought on CML running in families - perhaps families are

exposed to the same environmental factors so certain families are more

at risk for leukemia? By the way -the email link for ER from the NBC

website didn't work. I'm still trying to find one that does.

Barb

http://www.caringbridge.org/wi/tomneddo

On Jan 6, 2006, at 2:54 PM, Skip Duffie wrote:

[Guest guest]

HI everyone,

Unfortunately missed that ER eposiode which is probably the first time that i

have ever watched it. I also asked my doctor if my children should be tested

and she stated " IT IS NOT HEREDITARY " . Anyway below is an email address to the

NBC shows (ER) with any comments on it. I hope this helps and we all email them

our thoughts. I also thought (like everyone else) that the contacted doctors,

etc before filiming anything like that, but maybe this one just slipped by!!!

But again you can't slip anything by us huh??? LOL...LOL..

Hope everyone had a GREAT NEW YEAR!!!!

Penny

ER@... <ER@...>

Skip Duffie <skipd_2002@...> wrote: Hello all

well when I was diagnosed with CML many moons ago, I

was told that it was my exposure to RF that cause my

problem.

That is low dose radiation. I forgot the year but in

a may issue of QST (Ham publication) they had many

studies listed to prove that radiation causes

cancers..

below are a few quotes from sources about the question

can it be passed on from one generation to the next

and it looks like no is the answer

1. Analysis of information on leukaemia incidence and

mortality following external exposure to low linear

energy transfer (LET) radiation concluded that the

incidence of acute leukaemias and chronic myeloid

leukaemia (CML) exhibits strong associations with

external low LET radiation exposure.

For chronic myelogenous leukemia (CML), a malignancy

of the hematopoietic stem cell characterized by the

Philadelphia chromosome and the hybrid BCR-ABL fusion

gene, epidemiologic studies have failed to find any

reproducible, significant association with either

genetic or environmental factors except for ionizing

radiation and benzene. In order to find new evidence

for the hypothesis that CML is a combined result of

environmental exposure and genetic susceptibility, we

used the polymerase chain reaction (PCR)-based

genotyping approach described by Krajinovic et al

Heredity or Genetic Factors

1. There are no clear hereditary factors associated

with CML. Identical twins of patients with CML are at

no greater risk of developing CML than other siblings.

This strongly suggests that environmental factors are

much more important than genetic factors in the

development of CML. It is a scientific mystery as to

why only one of a pair of identical twins will develop

CML, since the genetics are identical and

environmental exposures are similar, if not the same.

HLA is the histocompatibility system that is used to

match people for bone marrow, liver and kidney

transplants. One study has found that a specific HLA

type, DR4, is associated with a lower incidence of

CML, however researchers have not yet identified the

reason for this decrease.

--- jenniferabosse wrote:

> Did anyone see the ER episode last night? There was

> a patient who had

> CML and he said that he inherited the Philidelphia

> Chromosome from his

> mother. I have been told that it is not inherited!!

> Thought it was

> interesting that they would say this!!

>

>

>

>

__________________________________________

DSL – Something to write home about.

Just $16.99/mo. or less.

dsl.

[Guest guest]

I for one believe that Leukemia does have some sort of inherited

traits. From my dad grandads, uncle, and cousin, to me. CML or

CLL. My dads cousin and I were both 34 when we were diagnosed with

CML, my Great Grandad I found out, had both CML and CLL. This is all

on my dads moms side of the family, not one generation missed<My

grandmothers dad cml/cll, brother cll, nephew cml, granddaughter

cml>. I think it is MUCH MORE than just a COINCIDENCE! I didn't grow

up in the same areas and wasn't around the same chemical compounds

and all that jazz. But I do have their GENES! AND THIER CML!

So....just some thoughts to ponder. So yep.....I've had CML for

almost 3 years, I inherited it from my dads side of the family!

Amy B. <dx 4/03>

>

> Hi Sheila,

> I believe there is NO scientific evidence that CML is inherited.

The

> disease has been understood (since the 1960's) and there is no

pattern of

> inheritance. It is an acquired mutation.

>

> That being said......people do inherit 'weaknesses' in their

genetic

> make-up....which could predispose someone to being more likely to

develop

> cancer, or a particular type of cancer, etc.

>

> Do you know that there is a certain % of the population that is

carrying

> the ph+ chromosome at any given time that does not develop

CML...this is

> because their immune system recognizes the ph+ translocation as a

defect

> and eliminates it.......this did not happen for those of us who go

on to

> develop CML. (This might be because our ph+ mutation occurred in a

primary

> stem cell???....this is one theory).

>

> Also, other leukemias are different....I don't believe their

mechanism of

> development is understood like CML....so to say that another

relative had a

> different kind of leukemia (such as CLL) also does not add to the

theory of

> it being inherited.

>

> CML is probably one of the most studied and researched

cancers...and the

> consensus is that it is not inherited.

>

> C.

>

>

[Guest guest]

I myself, have no history of any family member of having any type of cancer. I

was diagnosed 3 years ago. I lived in an area that sprayed for mosquitoes

during the summer months as a child. The house I lived in in New York also had

coal heating, so there you go, everything that does point to CML. I guess only

time will tell how we get it. I go to MD and they are adamant that it

isn't hereditary. I believe some cancers are, but I think CML has something to

do with chemicals that we are all around at one time or another and some of us

our genes just can't accept it. I don't profess to be a professionl but that is

the only conclusion that i can come to.

Penny

Cogan <ncogan@...> wrote:

At 07:36 PM 1/6/06 +0000, you wrote:

>I was told t his summer by an old Amish doctor that cml in also

>inherited he told me that I should have my girls checked out

>periodically. I had an Aunt that passe away from myelofibrosis

>which is an mpd so I don't know if that would have anything to do

>with me?? Of course she was in her early 70's and I'm

>37.

Hi Sheila,

I believe there is NO scientific evidence that CML is inherited. The

disease has been understood (since the 1960's) and there is no pattern of

inheritance. It is an acquired mutation.

That being said......people do inherit 'weaknesses' in their genetic

make-up....which could predispose someone to being more likely to develop

cancer, or a particular type of cancer, etc.

Do you know that there is a certain % of the population that is carrying

the ph+ chromosome at any given time that does not develop CML...this is

because their immune system recognizes the ph+ translocation as a defect

and eliminates it.......this did not happen for those of us who go on to

develop CML. (This might be because our ph+ mutation occurred in a primary

stem cell???....this is one theory).

Also, other leukemias are different....I don't believe their mechanism of

development is understood like CML....so to say that another relative had a

different kind of leukemia (such as CLL) also does not add to the theory of

it being inherited.

CML is probably one of the most studied and researched cancers...and the

consensus is that it is not inherited.

C.

[Guest guest]

Hello AMy,

That is pretty remarkable, the amount of CML in your family. It does

certainly make me wonder. Although I said I do not believe that there

is a genetic component to this, my mind is not so fixed as to not see

the possibility.

Thanks for sharing this.

Love, Peace and all good things,

Cheryl-Anne

>

> I for one believe that Leukemia does have some sort of inherited

> traits. From my dad grandads, uncle, and cousin, to me. CML or

> CLL. My dads cousin and I were both 34 when we were diagnosed with

> CML, my Great Grandad I found out, had both CML and CLL. This is all

> on my dads moms side of the family, not one generation missed<My

> grandmothers dad cml/cll, brother cll, nephew cml, granddaughter

> cml>. I think it is MUCH MORE than just a COINCIDENCE! I didn't grow

> up in the same areas and wasn't around the same chemical compounds

> and all that jazz. But I do have their GENES! AND THIER CML!

> So....just some thoughts to ponder. So yep.....I've had CML for

> almost 3 years, I inherited it from my dads side of the family!

>

> Amy B. <dx 4/03>

>