Methylcobalamin

[Guest guest]

Merle,

This is interesting, since I have some neurological problems. What form did

you take? Where did you get it? How much? How did you know you didn't need

it anymore?

Thanks in advance,

Methylcobalamin

Hi!

I used methylcobalamin for about three weeks to eliminate a B12 deficiency.

My bottle is labelled as the neuroligically active co-enzyme form of B12

and has a half life of 8 hours, which means

that it does not remain in your system very long. I thought that I would

have to take it indefinitely, but that was not the case. After three weeks,

it was like my methlcobalamin was topped up and

I didn't need it anymore. I took it in August and check peiordically, to see

if I need to start taking it again.

My impression was that it helps the nerves and don't know of a correlation

with mercruy.

Merle

[Guest guest]

Carole

I took B12 supplements and didn't notice any results. I read an article about

Methylcobalamin, a B12 enzyme with a short life span, and noticed a difference

as soon as I started taking it. I took

two bottles of sublingual methylcobalamin and haven't taken any since. I think

it corrected a B12 deficiency.

There have been other posts about problems with hydroxycobalamin injections. You

might want to check the archives and see if you can find some others that have

had a similar experience.

I also found MSM to be detrimental. I never used whey but read enough posts of

others that have had problems with it.

Unless toxic material is removed from the system by the skin, lungs, liver or

kidneys, it continues to circulate and can attack or attach itself to any number

of body systems. As I said in the

previous post, I think people with CFS have major problems because the toxins

have broken through the blood brain barrier that is supposed to protect our

brain from toxic material.

My personal opinion is that individuals with CFS are too sick to handle

treatments that mobilize toxins. I think a better approach is to render the

toxins harmless with anti-oxidants when they get

into the blood stream. That might avoid the crash and burn that so many with CFS

experience.

I think recovering from CFS is a two-step process - remove toxic material with

anti-oxidants and rebuild organs/systems damaged by the toxic material.

Merle

Carole Sierpien wrote:

> I am trying to understand the detoxing process. Have been in a downward

> spiral for the past 3 months, seemingly as a result of hydroxycobalamin

> injections, but not sure.

>

> Here are my questions :

>

> (1) I understand that certain agents help to mobilize toxins (eg mercury),

> like B12, MSM, whey. Toxins that are buried in organs are freed and then

> what happens to them?

> (2) Why do we feel sick when toxins are mobilized?

> (3) And most important, what helps ELIMINATE them once they are mobilized?

> (4) Are hydroxycobalamin, selenium, cilantro, chlorella MOBILIZERS or

> ELIMINATORS (chelators?)?

>

> I seem to be particularly sensitive to agents like MSM, B12, whey. With

> whey, had terrific results for about 6 months and then gradually made me

> sick, which I understand now may be due to high cysteine. Problem is getting

> t

[Guest guest]

---Merle

What do you mean you took 2 bottles of methylcobalamin and sublingual?

How can you take a bottle of liquid and put it under your tongue? Or

were they pills? Can you tell me where you got them from, because I

started Hydroxylcobalamin and was supposed to take methylcobalamin

jabs with Dr Hyams, but I cancelled as I couldn't really afford to

see him so soon after the first appointment (£450 each time with

treatments).

So, please tell me where I can get this methylcobalamin and do you

put it under your tongue> What symptoms exactly does it improve??

In @y..., Merle <peerent@c...> wrote:

> Carole

>

> I took B12 supplements and didn't notice any results. I read an

article about Methylcobalamin, a B12 enzyme with a short life span,

and noticed a difference as soon as I started taking it. I took

> two bottles of sublingual methylcobalamin and haven't taken any

since. I think it corrected a B12 deficiency.

>

> There have been other posts about problems with hydroxycobalamin

injections. You might want to check the archives and see if you can

find some others that have had a similar experience.

>

> I also found MSM to be detrimental. I never used whey but read

enough posts of others that have had problems with it.

>

> Unless toxic material is removed from the system by the skin,

lungs, liver or kidneys, it continues to circulate and can attack or

attach itself to any number of body systems. As I said in the

> previous post, I think people with CFS have major problems because

the toxins have broken through the blood brain barrier that is

supposed to protect our brain from toxic material.

>

> My personal opinion is that individuals with CFS are too sick to

handle treatments that mobilize toxins. I think a better approach is

to render the toxins harmless with anti-oxidants when they get

> into the blood stream. That might avoid the crash and burn that so

many with CFS experience.

>

> I think recovering from CFS is a two-step process - remove toxic

material with anti-oxidants and rebuild organs/systems damaged by the

toxic material.

>

> Merle

>

>

> Carole Sierpien wrote:

>

> > I am trying to understand the detoxing process. Have been in a

downward

> > spiral for the past 3 months, seemingly as a result of

hydroxycobalamin

> > injections, but not sure.

> >

> > Here are my questions :

> >

> > (1) I understand that certain agents help to mobilize toxins (eg

mercury),

> > like B12, MSM, whey. Toxins that are buried in organs are freed

and then

> > what happens to them?

> > (2) Why do we feel sick when toxins are mobilized?

> > (3) And most important, what helps ELIMINATE them once they are

mobilized?

> > (4) Are hydroxycobalamin, selenium, cilantro, chlorella

MOBILIZERS or

> > ELIMINATORS (chelators?)?

> >

> > I seem to be particularly sensitive to agents like MSM, B12,

whey. With

> > whey, had terrific results for about 6 months and then gradually

made me

> > sick, which I understand now may be due to high cysteine. Problem

is getting

> > t

[Guest guest]

You can get sublingual methylcobalamin in 5mg tablets from lef.org That is

the highest dose I have seen in one pill.

Thanks,

Doris

p.s. I personally find much more benefit from hydroxy by shots, but I am

taking the methyl by mouth too since it seems that they both are beneficial

in different ways.

[Guest guest]

I took 5 mg Methylcobalamin sublingual lozenges. They are designed to be put

under the tongue and dissolved, rather than going through the digestive system.

I bought mine in a local health food store, but others have found it available

on the net (can't remember the sites). I paid $26.99 (Cdn) for 60 lozenges.

I felt for a long time that I had a B12 deficiency and it eliminated the

deficiency and improved brain and nerve function. Like so many symptoms of the

disease, improvement is a subjective call,

and all I can really say is that I went from barely being able to shop for

groceries (if I got home with my groceries, purse, and gloves that was a

successful trip) to being able to work full time

and take care of my home and garden.

I think Methylcobalmin was just one of the supplements that got me back on

track. Others include Magnesium and Malic Acid, Bilberry, Vitamin E and

Selenium, Halibut Oil. Calc.Phos 6x, Chasteberry,

Cilantro Tincture, Bancha Twig Tea, and Jian Pi Wan.

Merle

martin19671967 wrote:

> ---Merle

> What do you mean you took 2 bottles of methylcobalamin and sublingual?

> How can you take a bottle of liquid and put it under your tongue? Or

> were they pills? Can you tell me where you got them from, because I

>

> So, please tell me where I can get this methylcobalamin and do you

> put it under your tongue> What symptoms exactly does it improve??

>

>

>

[Guest guest]

Merle,

What is " short life span " Methylcobalamin?

How is it different from normal Methylcobalamin?

Is there a difference in the results between consuming

Methylcobalamin sublingually and subcutaneously?

Thanks,

Prashant

--- Merle <peerent@...> wrote:

> Carole

>

> I took B12 supplements and didn't notice any

> results. I read an article about Methylcobalamin, a

> B12 enzyme with a short life span, and noticed a

> difference as soon as I started taking it. I took

> two bottles of sublingual methylcobalamin and

> haven't taken any since. I think it corrected a B12

> deficiency.

__________________________________________________

[Guest guest]

Prashant

According the article I wrote, B12 is comprised of Two enzymes, hydroxyl, which

stays in the body for a long period of time and methyl, which has a life span of

8 hours, at which time it is half

its strength. 'Short life span' is normal methylcobalamin, all it means is that

it does not stay in the body for a long period of time.

From the posts I have read, a lot of individuals seem to crash from subcutaneous

Methylcobalamin. It could be too much at one time. The sublingual is more

gradual and perhaps the body just needs a

minute amount. My experience was that over a period of several months, I

continually reduced the amount I took.

Merle

Prashant Krishnan wrote:

> Merle,

> What is " short life span " Methylcobalamin?

> How is it different from normal Methylcobalamin?

> Is there a difference in the results between consuming

> Methylcobalamin sublingually and subcutaneously?

>

> Thanks,

> Prashant

>

> --- Merle <peerent@...> wrote:

> > Carole

> >

> > I took B12 supplements and didn't notice any

> > results. I read an article about Methylcobalamin, a

> > B12 enzyme with a short life span, and noticed a

> > difference as soon as I started taking it. I took

> > two bottles of sublingual methylcobalamin and

> > haven't taken any since. I think it corrected a B12

> > deficiency.

>

[Guest guest]

This is all in the archives, but I wanted to remind new people. There is

evidence for hydroxycobalamine and methylcobalamine being helpful. But they

do different things. Cheney recommend hydroxy by injection to detox and

protect the brain. The methyl has other benefits (which I can't remember).

If you want to be sure you are doing both, it seems you should take both.

That is what I do.

Thanks,

Doris

[Guest guest]

> Which is the best pharmacy to get this from? the injectable

5,000mcgs ? Also my letterst went out today to the top 5 tv shows for

million letter campaign. joyce

>

>

[Guest guest]

Methylcobalamin: A Potential Breakthrough in Neurological Disease

Japanese scientists have identified a form of vitamin B12 that protects against neurological disease and aging by a unique mechanism that differs from current therapies. Some of the disorders that may be preventable or treatable with this natural vitamin therapy, called methylcobalamin, include chronic fatigue syndrome, Parkinson's disease, peripheral neuropathies, Alzheimer's disease, muscular dystrophy and neurological aging. Americans have immediate access to this unique and new form of vitamin B12, and, unlike prescription drugs, it costs very little and is free of side effects.vitamin B12 is a general label for a group of essential biological compounds knows as cobalamins. The cobalamins are structurally related to hemoglobin in the blood, and a deficiency of vitamin B12 can cause anemia. The primary concern of conventional doctors is to maintain adequate cobalamin status to protect against anemia.The most common form of vitamin B12 is called cyanocobalamin. However, over the last ten years, a number of central and peripheral neurological diseases have been linked to a deficiency of a very specific cobalamin, the methylcobalamin form, that is required to protect against neurological diseases and aging. The liver converts a small amount of cyanocobalamin into methylcobalamin within the body, but larger amounts of methylcobalamin are necessary to correct neurological defects and protect against aging.Published studies show that high doses of methylcobalamin are needed to regenerate neurons as well as the myelin sheath that protects nerve axons and peripheral nerves.CFIDS and B-12In the Summer 1998 issue of Healthwatch, an important research article reported a fascinating new finding. Over 60% of CFIDS and FM patients cerebral spinal fluids contained subnormal levels of vitamin B12. On the other hand, vitamin B12 levels in the blood did not significantly deviate from normal ranges.According to Dr. Cheney's treatment pyramid for CFIDS, vitamin B12 in its non-cyanocobalamin form (the type commercially available) is a potent detoxifier of the brain. Recent studies in Europe suggest that it needs to be given in large doses in the range of 10 - 20 mg per day, or even more. This supplementation of methylcobalamin might protect the cognitive function of patients with CFIDS by preventing the death of brain cells.One cause of brain cell death is glutamate toxicity. Brain cells use glutamate as a neurotransmitter, but unfortunately glutamate is a double-edged sword in that it can also kill brain cells. The release of glutamate from the synapses is a usual means by which neurons communicate with each other.Effective communication means controlled release of glutamate at the right time to the right cells, but when glutamate is released in excessive amounts, intercellular communication ceases. The flood of glutamate into the receiving neurons drives them into hyperactivity, and the excessive activity leads to cellular degradation.The good news is that it may now be possible to protect brain cells against glutamate toxicity by taking methylcobalamin supplementation. In a study in the European Journal of Pharmacology, it was shown that methylcobalamin protected against glutamate-, aspartate- and nitroprusside- induced neurotoxicity in rat cortical neurons.Researchers concluded that methylcobalamin protects against neurotoxicity by enhancing brain cell methylation. The CFIDS & Fibromyalgia Health Resource recommends methylation-enhancing therapies such as vitamin B6, vitamin B12, folic acid and trimethylglycine (TMG), taken together, to protect against heart disease, stroke and other aging-related diseases. The scientists who conducted the methylcobalamin studies emphasize that ongoing intake of methylcobalamin is necessary to protect against neurotoxicity. Thus for methylcobalamin to be effective in protecting against neurological disease, daily supplementation may be required.An appropriate dose to protect against neurological aging might be 1 to 5 mg a day taken under the tongue in lozenge form.SleepA recent German study appearing in Neuropharmacology showed methylcobalamin reduced the amount of time subjects slept; sleep quality was better and subjects awoke feeling refreshed, with better alertness and concentration. Part of this effect was apparently due to melatonin suppression during the daytime because morning methylcobalamin supplementation reduces drowsiness by decreasing daytime melatonin levels. Multiple SclerosisAccording to a recent study at Vanderbilt University, chlamydia pneumoniae might link multiple sclerosis (MS) to CFIDS. This makes the published effect of methylcobalamin treatment on MS of great importance to those who suffer from CFIDS.A study in the Journal of Internal Medicine investigated the daily administration of 60 mg of methylcobalamin to patients with chronic progressive multiple sclerosis (MS), a disease that has a poor prognosis and feature side spread demyelination in the central nervous system.Although motor disability did not improve, there were clinical improvements in visual and auditory MS related disabilities. The scientist stated that methylcobalamin might be an effective adjunct to immunosuppressive treatment for chronic, progressive MS. Those with less serious forms of MS may consider adding methylcobalamin to their daily treatment regimen.The effects of methylcobalamin were studied on an animal model of muscular dystrophy. This study, published in Neuroscience Letter looked at degeneration of axon motor terminals. In mice receiving methylcobalamin, nerve sprouts were more frequently observed and regeneration of motor nerve terminals occurred in sites that had been previously degenerating.Regenerating NervesFew substances have been shown to regenerate nerves in humans with peripheral neuropathies. However, a study in the Journal of Neurological Science postulated that methylcobalamin could increase protein synthesis and help regenerate nerves. The scientists showed that very high doses of methylcobalamin produce nerve regeneration in laboratory rats.The scientists stated that ultra-high doses of methylcobalamin might be of clinical use for patients with peripheral neuropathies. The human equivalent dose the scientists used is about 40 mg of sublingually administered methylcobalamin on a daily basis.Those suffering from peripheral neuropathies often take alpha lipoic acid. Based on our new understanding of peripheral neuropathy, it may be prudent that anyone using alpha lipoic acid also take at least 5 mg a day of sublingually administered methylcobalamin to ensure that alpha lipoic acid will be bioavailable to the peripheral nerves.Cancer/Immune FunctionA study in the journal Oncology examined the effects of methylcobalamin on several different kinds of tumors in mice. The administration of methylcobalamin for seven days suppressed liver, lung and ascites tumor growth. Mice receiving methylcobalamin survived longer than control mice did. In mice irradiated before tumor cell inoculation, methylcobalamin did not improve survival.The effects of methylcobalamin on human immune function was investigated in the Journal of Clinical Immunology. The study showed that methylcobalamin demonstrated remarkable T cell-enhancing effects when the T cells were exposed to certain antigens.The scientists also showed that methylcobalamin improved the activity of T helper cells. The scientists concluded that methylcobalamin could modulate lymphocyte function by augmenting regulatory T cell activities.Americans need to know about this important natural therapy that could extend the healthy human life span. A search of the scientific literature reveals 334 published studies on methylcobalamin. However, it would not be an exaggeration to say that virtually no doctors know of it or are recommending it.Methylcobalamin should be considered for the treatment of any neurological disease. For example, based on its unique mechanisms of action, methylcobalamin could be effective in slowing the progression of "untreatable" diseases such as ALS (Lou Gerhig's disease).Since methylcobalamin is not a drug, there is little economic incentive to conduct expensive clinical studies on it, so it may be a long time before we know just how effective this unique form of vitamin B12 is in slowing the progression of common diseases like Parkinson's disease.The sublingual intake of methylcobalamin is an affordable and effective natural therapy, and has proven even safe when given in large doses.(euro-journ-pharm; 1993 Sep.7;7;241 (1):1-6) (Experientia; 1992 Aug;48[8]:716-720)(Neuropharmacology; 1996;15[5]:456-464)(journ-int-med; 1994 Feb. 33(2):82-86)(Neuroscience Letter; 1994 Mar 28; 170[1] 195-197)(journ-neuro-sci 1994 Apr. 122[2]:140-143)(journ-inherited-meta-dis 1993;16[4]:762-770) (Oncology; 1987;44[3]:169-173)(journ-clin-immuno 1982 Apr 2;[2]:101-109) http://www.immunesupport.com/message/neurob12.htm

Qadoshyah

www.gotdownsyndrome.net