Genotype 2 Extending Therapy With Peg/Riba

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Genotype 2 Extending Therapy With Peg/Riba

Intervirology. 2010 Mar 3;53(3):188-192.

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Extending Combination Therapy with Peginterferon plus Ribavirin for Genotype 2 Chronic Hepatitis C Virological Responders: A Pilot Study of 7 Cases.

..Akuta N, Suzuki F, Arase Y, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Ikeda K, Kumada H.Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

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Objective: In treatment-resistant patients with genotype 2 chronic hepatitis C the suitable treatment duration is still unclear.The aims were to investigate extending combination therapy with peginterferon plus ribavirin for genotype 2.Methods: 7 patients infected with genotype 2 at a high viral load and who did not achieve a sustained virological response (SVR) with the first course of 24-week IFN plus ribavirin were recruited into the study protocol with a total of 48 weeks of peginterferon plus ribavirin therapy.Results: SVR was achieved in 5 of 7 patients (71%). All 4 patients (100%) who were in relapse with the first course achieved SVR.Only 1 of 3 patients (33%) who had a non-virological response (NVR) with the first course achieved SVR. All 4 patients who

had an early virological response (EVR) with the first course achieved EVR and SVR.Two of 3 patients who had no EVR with the first course also did not achieve EVR and SVR. One patient who had no EVR or a NVR during the first course achieved EVR and SVR with the second course. Conclusions: Our results suggest that extending combination therapy for genotype 2 chronic hepatitis C might be useful for patients who relapse following 24-week combination therapy.

.. S. Karger AG, Basel.PMID: 20197686

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http://www.ncbi.nlm.nih.gov/pubmed/20197686http://www.ncbi.nlm.nih.gov/pubmed/20197686

http://Hepatitis Cnewdrugs.blogspot.com/2010/03/genotype-2-extending-therapy-with.html