Fw: New discussion: PhV in medical research - XXIII

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Dear members,

The commonly used causality assessment scale - Naranjo's scale is objective method of assessment. The two most important questions it it are -

1) Did the AR reappear when drug was readministered (Rechallenge)?

2) Was the drug detected in the blood [or other fluids] in a concentration known to be toxic?

Rechallenge with drug is "Generally" not done (but if done it has to be with utmost precautions and starting with lower dose in cases of serious AEs)

Also, blood concentration of the drug is generally not meaured.

Because of these two important reasons, the Nanranjo's score comes to be Probable or possible.

Regards, Dr. Vijay M. katekhayePostgraduate StudentDept. of Pharmacology,LTMMC & LTMGH, Sion,Mumbai - 400 022 Ph - +919619313060

----- Forwarded Message ----From: Dr. vijay Katekhaye <dr.vijaykatekhaye@...>netrum Sent: Fri, 29 October, 2010 8:22:22 PMSubject: New discussion: PhV in medical research - XVI

Dear members,The most of the results for the Naranjo's Causality Assessment scale fall between the probable or possible category.What is most important factor responsible for such happening? or in other words, what is the most important factor in Naranjo's causality assessment scale?

Regards,Dr. Vijay M. katekhayePostgraduate StudentDept. of Pharmacology,LTMMC & LTMGH, Sion,Mumbai - 400 022 Ph - +919619313060