Re: Re: SOY...A goitrogen!!!

[Guest guest]

I just did a quick search on "iodine, soy, goitrogen" and found an article with the following quotes. They talk about how

Isoflavones are inhibitors of the thyroid peroxidase which makes T3 and T4. I was just reading in my thyroid book this morning about the importance of peroxidase in making thyroid hormones from iodine. So, this almost makes sense to me.

These quotes also suggest that there is a goitrogen in soy that prevents the absorption of iodine from the gastrointestinal tract.

Another quote says, "we have identified genistein and daidzein as the goitrogenic isoflavonoid components of soy and defined the mechanisms for inhibition of thyroid peroxidase (TPO)-catalyzed thyroid hormone synthesis in vitro."

So, it certainly looks like we have some very strong evidence here that soy interferes with iodine utilization by the body.

I had not fully appreciated that this is one of the effects of soy. I certainly need to research this further.

Zoe

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Isoflavones are inhibitors of the thyroid peroxidase which makes T3 and T4. Inhibition can be expected to generate thyroid abnormalities, including goiter and autoimmune thyroiditis. There exists a significant body of animal data that demonstrates goitrogenic and even carcinogenic effects of soy products.

"In studying the literature on soy I found there are about five types of plant chemicals in the soybean that can be toxic to humans if they are not removed by special processing… the fifth antinutrient in soybeans is called a goitrogen. This is a chemical that latches on to iodine, preventing it from absorbing into the body from the gastrointestinal tract.

Moreover, there are significant reports of goitrogenic effects from soy consumption in human infants (cf., Van Wyk et al., 1959; Hydovitz, 1960; Shepard et al., 1960; Pinchers et al., 1965; Chorazy et al., 1995) and adults (McCarrison, 1933; Ishizuki, et al., 1991). Recently, we have identified genistein and daidzein as the goitrogenic isoflavonoid components of soy and defined the mechanisms for inhibition of thyroid peroxidase (TPO)-catalyzed thyroid hormone synthesis in vitro (Divi et al., 1997; Divi et al., 1996). The observed suicide inactivation of TPO by isoflavones, through covalent binding to TPO, raises the possibility of neoantigen formation and because anti-TPO is the principal autoantibody present in auto immune thyroid disease.

McCarrison, R. The goitrogenic action of soybean and groundnut. Indian J. Med. Res. 21, 179-181, 1933.There are significant reports of goitrogenic effects from soy consumption in human infants (cf., Van Wyk et al., 1959; Hydovitz, 1960; Shepard et al., 1960; Pinchers et al., 1965; Chorazy et al., 1995) and adults (McCarrison, 1933; Ishizuki, et al., 1991).

We have identified genistein and daidzein as the goitrogenic isoflavonoid components of soy and defined the mechanisms for inhibition of thyroid peroxidase (TPO)-catalyzed thyroid hormone synthesis in vitro (Divi et al., 1997; Divi et al., 1996).

Even with the change to soy protein isolate, FDA bureaucrats engaged in the "rigorous approval process" were forced to deal nimbly with concerns about mineral blocking effects, enzyme inhibitors, goitrogenicity, endocrine disruption, reproductive problems and increased allergic reactions from consumption of soy products.

It is inappropriate to allow a health claim for Soy Protein Isolate, SPI, … it could be misinterpreted, … the health labeling of SPI for foods needs to be considered just as would the addition of any Estrogen or Goitrogen to foods, which are bad ideas. Estrogenic and goitrogenic drugs are regulated by the FDA, and are taken under a physicians care. Patients are informed of risks, and are monitored by their physicians for evidence of toxicity. No similar safeguards are in place for foods, so the public will be put at potential risk from soy isoflavones in SPI without adequate warning and information...

2002 Goitrogenic and estrogenic activity of soy isoflavones, Doerge D.R. and D.M. Sheehan, Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA.

Although safety testing of natural products, including soy products, is not required, the possibility that widely consumed soy products may cause harm in the human population via either or both estrogenic and goitrogenic activities is of concern.

The above quotes are all from http://www.senselessplanet.com/medicalresearch.htm

Zoe

Re: SOY...A goitrogen?

> Do you know if she talks about soy as a goitrogen? Zoe----> Oh yes she has plenty to say about that. I'd have to go dig thebook for the references and exactly what she says but I can if anyoneis interested.Lynn

[Guest guest]

I just found this interesting article on Hypothyroidism in Green Iguanas . It is talking about the feeding of iguanas, and how to avoid the goitrogenic foods.

Here are a few quotes: "Goitrogenic foods are those which contain iodine binders. When the body cannot get enough iodine, a goiter forms, which impairs thyroid function, causing hypothyroidism. Feeding goitrogenic foods as a significant part of the diet, human and iguana, can thus lead to hypothyroidism....

Of the plant parts most commonly fed, the plants with problematic levels of one or more goitrogens: Cabbages (Red, white, etc.), Garden cress, Grapes, Kale (curly kale, Kitchen kale, Scotch kale), Mango, Pea.

Some plants have both iodine and iodine-binders, such as: Kelp, Soybean. Like spinach, which has both calcium and calcium oxalate, the goitrogen in kelp, for example, may be enough to bind the iodine it contains and other iodine in the diet."

This brings up the issue of goitrogen in kelp. Is she talking about bromide, or something else?

She mentions a database for looking up goitrogens: Phytochemical and Ethnobotanical Databases

Zoe

[Guest guest]

Do you think you could post a list of foods that contain the good things for our goiters to help shrink them and to help not make them grow anymore?

Thanks, It would help me when I grocery shop.

Re: Re: SOY...A goitrogen!!!

I just found this interesting article on Hypothyroidism in Green Iguanas . It is talking about the feeding of iguanas, and how to avoid the goitrogenic foods.

Here are a few quotes: "Goitrogenic foods are those which contain iodine binders. When the body cannot get enough iodine, a goiter forms, which impairs thyroid function, causing hypothyroidism. Feeding goitrogenic foods as a significant part of the diet, human and iguana, can thus lead to hypothyroidism....

Of the plant parts most commonly fed, the plants with problematic levels of one or more goitrogens: Cabbages (Red, white, etc.), Garden cress, Grapes, Kale (curly kale, Kitchen kale, Scotch kale), Mango, Pea.

Some plants have both iodine and iodine-binders, such as: Kelp, Soybean. Like spinach, which has both calcium and calcium oxalate, the goitrogen in kelp, for example, may be enough to bind the iodine it contains and other iodine in the diet."

This brings up the issue of goitrogen in kelp. Is she talking about bromide, or something else?

She mentions a database for looking up goitrogens: Phytochemical and Ethnobotanical Databases

Zoe

[Guest guest]

Sorry to interrupt. When you say inhibitors to the thyroid, do you mean that soy products in general are bad b/c they don't allow the thyroid to make the T3 and T4 hormones?

Thanks in advance for the side note. I just woke up and read this and was not sure if I heard that correctly. Interesing, b/c I eat a lot of soy products.

Re: SOY...A goitrogen?

> Do you know if she talks about soy as a goitrogen? Zoe----> Oh yes she has plenty to say about that. I'd have to go dig thebook for the references and exactly what she says but I can if anyoneis interested.Lynn

[Guest guest]

I found another good article that talks about the goitrogens in soy:

Don't Go Overboard With the Soy Foods. Interview Researcher of the Month - Zava, Ph.D.

Some quotes: "The primary toxins in soybeans include allergens, phytates, protease inhibitors, genistein, and goitrogens....

The fifth anti-nutrient in soybeans is called a goitrogen. This is a chemical that latches on to iodine, preventing it from absorbing into the body from the gastrointestinal tract....

Soy also contains goitrogens - substances that depress thyroid function....

FDA bureaucrats engaged in the "rigorous approval process" were forced to deal nimbly with concerns about mineral blocking effects, enzyme inhibitors, goitrogenicity, endocrine disruption, reproductive problems, and increased allergic reactions from consumption of soy products."

Zoe

[Guest guest]

"When you say inhibitors to the thyroid, do you mean that soy products in general are bad b/c they don't allow the thyroid to make the T3 and T4 hormones?" -- My Group

Dear "My Group",

I'm sure not an expert on this -- I just started learning this last night! But that is the way it sounds to me: "Isoflavones are inhibitors of the thyroid peroxidase which makes T3 and T4."

Of course, whether you label the soy products as "bad" is up to you. They do seem to interfere with iodine. On the other hand, while skimming the research last night, it seemed as if the effects were worse if you were already low in iodine. So, if you had high levels of iodine already, they probably wouldn't be as "bad".

Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action.

I don't know if there are any ways of preparing soy (e.g., fermentation) that change this goitrogenic effect.

Zoe

[Guest guest]

Thanks for the info, most appreciated, I'll certainly take your word for that. I *do* need to lay off soy products then, b/c I never had a goiter until I started that, but there again are many other factors to the cause of them, and in my case it almost seems as if it was another medication caused it for me.

Thank you for the link and wonderful info on this. I'm ceasing the intake of soy as of today , I want to promote good thyroid hormone stimulation/creation, not inhibit it. I know your not a doctor, but I will certainly take your word for it.

Re: Re: SOY...A goitrogen!!!

"When you say inhibitors to the thyroid, do you mean that soy products in general are bad b/c they don't allow the thyroid to make the T3 and T4 hormones?" -- My Group

Dear "My Group",

I'm sure not an expert on this -- I just started learning this last night! But that is the way it sounds to me: "Isoflavones are inhibitors of the thyroid peroxidase which makes T3 and T4."

Of course, whether you label the soy products as "bad" is up to you. They do seem to interfere with iodine. On the other hand, while skimming the research last night, it seemed as if the effects were worse if you were already low in iodine. So, if you had high levels of iodine already, they probably wouldn't be as "bad".

Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action.

I don't know if there are any ways of preparing soy (e.g., fermentation) that change this goitrogenic effect.

Zoe

[Guest guest]

What do you guys think about an IODIONE supplement:

e.g. IOSOL. I've had this product and NOT used it consistently or at all for years. It is the highest portency per say and made by TPCS. 1 tsp losol solution prepares 153mcg / 102% of Iodione, and its made up of Glycerine, (vergitarian), Iodine, Amomonium Iodide.

It claims to be non-toxic and water soluable (I assume so you can put it in water and mix it up and drink it).

This is the exact product here: http://www.tpcsdirect.com/

Re: SOY...A goitrogen!!!

I'm thinking the iodine in kelp must outweigh the iodine-binders since I had to stop taking my thyroid meds after starting kelp? > Some plants have both iodine and iodine-binders, such as: Kelp, Soybean. Like spinach, which has both calcium and calcium oxalate, the goitrogen in kelp, for example, may be enough to bind the iodine it contains and other iodine in the diet." > > This brings up the issue of goitrogen in kelp. Is she talking about bromide, or something else?

[Guest guest]

Gail,

While unfermented soy has goitrogenic properties. Fermented soy, such as miso or tempeh are okay because they are essentially somewhat predigested.

While tofu has added an enzyme to gel it, it is not fermented so it, like soy milk still has goitrogenic properties.

On 2/23/06, Gail the Zoo Keeper <gailandbarry@...> wrote:

This fascinates me........ while I was vegetarian, in the last few years I just kept getting sick, one thing after another. It just seemed that I was always catching everything that ever thought about going around. In the early years of vegetarianism I felt great.... I suppose when it came up to around 20 years my body had been depleted of important stores of nutrients. I did consume lots of soy in the form of tofu, textured veg protein etc. It's hard to get away from soy if you look at the labels of anything. Yes...... going back to the basics is a good thing.

Gail

The Ga. Zoo Keeper

From: Zoe &

I found another good article that talks about the goitrogens in soy:

Don't Go Overboard With the Soy Foods. Interview Researcher of the Month - Zava, Ph.D.

[Guest guest]

Do you have a reference on this?

Re: Re: SOY...A goitrogen!!!

Gail,

While unfermented soy has goitrogenic properties. Fermented soy, such as miso or tempeh are okay because they are essentially somewhat predigested.

While tofu has added an enzyme to gel it, it is not fermented so it, like soy milk still has goitrogenic properties.

On 2/23/06, Gail the Zoo Keeper <gailandbarry@...> wrote:

This fascinates me........ while I was vegetarian, in the last few years I just kept getting sick, one thing after another. It just seemed that I was always catching everything that ever thought about going around. In the early years of vegetarianism I felt great.... I suppose when it came up to around 20 years my body had been depleted of important stores of nutrients. I did consume lots of soy in the form of tofu, textured veg protein etc. It's hard to get away from soy if you look at the labels of anything. Yes...... going back to the basics is a good thing.

Gail

The Ga. Zoo Keeper

From: Zoe &

I found another good article that talks about the goitrogens in soy:

Don't Go Overboard With the Soy Foods. Interview Researcher of the Month - Zava, Ph.D.