RE: Interesting article on irreversible damage in MS

[Guest guest]

Hans Neiper was right about attacking MS at the molecular. I have been on his Calcium 2-AEP therapy since May 10th and am feeling so much better. The iv injections are admitedly more difficult than the others but their effectiveness is worth it.

Beth Ravenelle

>From: "rosemist50" <markhgailf@...> >Reply-low dose naltrexone >low dose naltrexone >Subject: [low dose naltrexone] Interesting article on irreversible damage in MS >Date: Fri, 28 May 2004 17:19:40 -0000 > > > >Public release date: 27-May-2004 > > >Contact: Weaver >jacqueline.weaver@... >203-432-8555 >Yale University > >Researchers identify basis for irreversible damage in multiple sclerosis > >New Haven, Conn. -- Yale researchers and collaborators have >identified molecules that underlie nerve fiber degeneration in >patients with secondary progressive multiple sclerosis (MS), a >disease that cripples nearly three million people worldwide. The new >findings are the first observations in humans of molecules that >contribute to degeneration of nerve fibers. > >Researchers at Yale, the Veterans Administration (VA) and University >College London examined postmortem spinal cord tissue from patients >with a progressive form of MS in a project supported by the >Department of Veterans Affairs, National MS Society, Paralyzed >Veterans of America, and the United Spinal Association. Using >biomarkers of the damaged nerve fibers, they looked for molecular >abnormalities and found a strong link between nerve damage and the >presence of two molecules, Nav. 1.6 and NCX, a sodium channel and a >sodium-calcium exchanger. > >Located on the surface of most nerve fibers, Nav.1.6 controls the >flow of sodium into the cell, which in turn triggers the activation >of NCX, a molecule that, if unchecked, imports abnormal levels of >calcium into the nerve fiber that ultimately lead to its death. > >"These results are extremely exciting because they provide, for the >first time, important clues about the molecular basis for permanent >and irreversible damage in MS," said Waxman, M.D., the lead >investigator, chair of neurology and director of the VA >Rehabilitation Research and Development Center in West Haven. "We >hope to use these results to design new therapies that will protect >vulnerable nerve fibers." > >MS is an inflammatory disease of the central nervous system in which >myelin, the insulation that surrounds the nerve fibers, is damaged in >multiple regions, leaving scars that hinder the relay of nerve >signals from the brain to the rest of the body. > >One of the hallmark features of MS is a relapsing-remitting course in >some patients. There is molecular rebuilding of nerve fibers, relay >of nerve signals even in the absence of myelin, and recovery of >previously lost functions such as the ability to see or walk, as the >disease remits. Patients with the relapsing-remitting form of MS are >neurologically normal between relapses, and do not develop permanent >disability. > >However, in progressive forms of the disease, entire lengths of the >nerve fibers begin to degenerate, resulting in permanent and >irreparable damage, a steady worsening of symptoms and accumulation >of disability. > >### >Co-authors included Craner, M.D., and Black of Yale and >the VA. The three researchers are part of Yale-London Collaboration >on Nervous System Injury and Repair. > >Citation: PNAS, May 17, 2004, 10.1073/pnas.0402765101 (Early Edition) >-- > > Stop worrying about overloading your inbox - get MSN Hotmail Extra Storage!