Genotypes

[Guest guest]

Dear Amy:

Depending on how you want to describe the genotypes, 1b, is not the

one of choice, but, then again, you are part of the US majority. The 1a

and 1b do not respond as easily to current therapy, ie: either do not

respond at all, do not go into remission as easily, and may relapse more

quickly.

The whole issue of genotype is still one of controversy and

depending on which study you read, and what they are trying to prove,

will either depress you, or be meaningless. Since the genotype nor the

results of the " biopsy " are parts of the protocol for current treatment,

that could change in the future.

I have treated many people who have a genotype of 1b, (about 75%),

and the others have been mixed, depending on how they got the virus. I

think this is one area that people should not read too much into yet,

because we do not know enough. Some have responded excellently and there

are people who have not shown a detectable viral load for 5-10 years, on

current therapeutic regimes.

Basically, the current treatment lengths, of the combo therapy has

been to treat for 24 weeks, if the person can tolerate the therapy, and,

if it is having some positive effects against keeping the viral loads

down, and the liver enzymes from being elevated. If no real effect, then

a person stops at 24 weeks. If genotype 1a or 1b, if you are responding,

then you are usually placed on another 24 weeks. In reality, it is not a

full " year " , but, a total of 48 weeks. Originally, there was some that

went for 72 weeks if they were responding, but, that is not as

frequently seen today.

Also, a major factor is how your body tolerates the meds. You do not

need to place HCV into a " non-detectable " state, and wind up with

something worse because your blood counts are so low, you are either too

anemic or too immunocompromised and you leave yourself open for

additional problems. But, assuming that you progress " normally " , even if

certain blood counts drop very low, and your provider about whether

certain cell stimulating drugs would help, ie: Neupogen or Epogen, to

increase your counts. This means another injection several times a week,

but, it is better then stopping, or getting sicker.

Just try to keep informed and take each day at a time. If you do not

have confidence in your provider, speak to him/her, and if that does not

solve the problem, find a new provider. This disease is tough enough

without adding outside negative influences. Depression is usually seen,

(beyond the normal " grieving " process), in most people, and has to be

watched carefully beginning a round the 3rd month to 5-6 months, when it

seems to have the most negative effects.

I believe that a great deal of how a person responds is based on

some type of psychological impact that we do not know, or understand

enough about yet. But, a " state of mind " will definitely impact on any

treatment or disease.

I hope this helps some. Keep smiling. Marty

[Guest guest]

Dear Amy:

Depending on how you want to describe the genotypes, 1b, is not the

one of choice, but, then again, you are part of the US majority. The 1a

and 1b do not respond as easily to current therapy, ie: either do not

respond at all, do not go into remission as easily, and may relapse more

quickly.

The whole issue of genotype is still one of controversy and

depending on which study you read, and what they are trying to prove,

will either depress you, or be meaningless. Since the genotype nor the

results of the " biopsy " are parts of the protocol for current treatment,

that could change in the future.

I have treated many people who have a genotype of 1b, (about 75%),

and the others have been mixed, depending on how they got the virus. I

think this is one area that people should not read too much into yet,

because we do not know enough. Some have responded excellently and there

are people who have not shown a detectable viral load for 5-10 years, on

current therapeutic regimes.

Basically, the current treatment lengths, of the combo therapy has

been to treat for 24 weeks, if the person can tolerate the therapy, and,

if it is having some positive effects against keeping the viral loads

down, and the liver enzymes from being elevated. If no real effect, then

a person stops at 24 weeks. If genotype 1a or 1b, if you are responding,

then you are usually placed on another 24 weeks. In reality, it is not a

full " year " , but, a total of 48 weeks. Originally, there was some that

went for 72 weeks if they were responding, but, that is not as

frequently seen today.

Also, a major factor is how your body tolerates the meds. You do not

need to place HCV into a " non-detectable " state, and wind up with

something worse because your blood counts are so low, you are either too

anemic or too immunocompromised and you leave yourself open for

additional problems. But, assuming that you progress " normally " , even if

certain blood counts drop very low, and your provider about whether

certain cell stimulating drugs would help, ie: Neupogen or Epogen, to

increase your counts. This means another injection several times a week,

but, it is better then stopping, or getting sicker.

Just try to keep informed and take each day at a time. If you do not

have confidence in your provider, speak to him/her, and if that does not

solve the problem, find a new provider. This disease is tough enough

without adding outside negative influences. Depression is usually seen,

(beyond the normal " grieving " process), in most people, and has to be

watched carefully beginning a round the 3rd month to 5-6 months, when it

seems to have the most negative effects.

I believe that a great deal of how a person responds is based on

some type of psychological impact that we do not know, or understand

enough about yet. But, a " state of mind " will definitely impact on any

treatment or disease.

I hope this helps some. Keep smiling. Marty

[Guest guest]

Dear Amy:

Depending on how you want to describe the genotypes, 1b, is not the

one of choice, but, then again, you are part of the US majority. The 1a

and 1b do not respond as easily to current therapy, ie: either do not

respond at all, do not go into remission as easily, and may relapse more

quickly.

The whole issue of genotype is still one of controversy and

depending on which study you read, and what they are trying to prove,

will either depress you, or be meaningless. Since the genotype nor the

results of the " biopsy " are parts of the protocol for current treatment,

that could change in the future.

I have treated many people who have a genotype of 1b, (about 75%),

and the others have been mixed, depending on how they got the virus. I

think this is one area that people should not read too much into yet,

because we do not know enough. Some have responded excellently and there

are people who have not shown a detectable viral load for 5-10 years, on

current therapeutic regimes.

Basically, the current treatment lengths, of the combo therapy has

been to treat for 24 weeks, if the person can tolerate the therapy, and,

if it is having some positive effects against keeping the viral loads

down, and the liver enzymes from being elevated. If no real effect, then

a person stops at 24 weeks. If genotype 1a or 1b, if you are responding,

then you are usually placed on another 24 weeks. In reality, it is not a

full " year " , but, a total of 48 weeks. Originally, there was some that

went for 72 weeks if they were responding, but, that is not as

frequently seen today.

Also, a major factor is how your body tolerates the meds. You do not

need to place HCV into a " non-detectable " state, and wind up with

something worse because your blood counts are so low, you are either too

anemic or too immunocompromised and you leave yourself open for

additional problems. But, assuming that you progress " normally " , even if

certain blood counts drop very low, and your provider about whether

certain cell stimulating drugs would help, ie: Neupogen or Epogen, to

increase your counts. This means another injection several times a week,

but, it is better then stopping, or getting sicker.

Just try to keep informed and take each day at a time. If you do not

have confidence in your provider, speak to him/her, and if that does not

solve the problem, find a new provider. This disease is tough enough

without adding outside negative influences. Depression is usually seen,

(beyond the normal " grieving " process), in most people, and has to be

watched carefully beginning a round the 3rd month to 5-6 months, when it

seems to have the most negative effects.

I believe that a great deal of how a person responds is based on

some type of psychological impact that we do not know, or understand

enough about yet. But, a " state of mind " will definitely impact on any

treatment or disease.

I hope this helps some. Keep smiling. Marty

[Guest guest]

Dear Amy:

Depending on how you want to describe the genotypes, 1b, is not the

one of choice, but, then again, you are part of the US majority. The 1a

and 1b do not respond as easily to current therapy, ie: either do not

respond at all, do not go into remission as easily, and may relapse more

quickly.

The whole issue of genotype is still one of controversy and

depending on which study you read, and what they are trying to prove,

will either depress you, or be meaningless. Since the genotype nor the

results of the " biopsy " are parts of the protocol for current treatment,

that could change in the future.

I have treated many people who have a genotype of 1b, (about 75%),

and the others have been mixed, depending on how they got the virus. I

think this is one area that people should not read too much into yet,

because we do not know enough. Some have responded excellently and there

are people who have not shown a detectable viral load for 5-10 years, on

current therapeutic regimes.

Basically, the current treatment lengths, of the combo therapy has

been to treat for 24 weeks, if the person can tolerate the therapy, and,

if it is having some positive effects against keeping the viral loads

down, and the liver enzymes from being elevated. If no real effect, then

a person stops at 24 weeks. If genotype 1a or 1b, if you are responding,

then you are usually placed on another 24 weeks. In reality, it is not a

full " year " , but, a total of 48 weeks. Originally, there was some that

went for 72 weeks if they were responding, but, that is not as

frequently seen today.

Also, a major factor is how your body tolerates the meds. You do not

need to place HCV into a " non-detectable " state, and wind up with

something worse because your blood counts are so low, you are either too

anemic or too immunocompromised and you leave yourself open for

additional problems. But, assuming that you progress " normally " , even if

certain blood counts drop very low, and your provider about whether

certain cell stimulating drugs would help, ie: Neupogen or Epogen, to

increase your counts. This means another injection several times a week,

but, it is better then stopping, or getting sicker.

Just try to keep informed and take each day at a time. If you do not

have confidence in your provider, speak to him/her, and if that does not

solve the problem, find a new provider. This disease is tough enough

without adding outside negative influences. Depression is usually seen,

(beyond the normal " grieving " process), in most people, and has to be

watched carefully beginning a round the 3rd month to 5-6 months, when it

seems to have the most negative effects.

I believe that a great deal of how a person responds is based on

some type of psychological impact that we do not know, or understand

enough about yet. But, a " state of mind " will definitely impact on any

treatment or disease.

I hope this helps some. Keep smiling. Marty

[Guest guest]

Thanks, Marty for what you said. I under stand a little more about

genotypes. Their is just so much to keep up with. You put it where I

could understand Thank you again Jessie, I do try to live one day at a

time.

EZ-DOES IT

[Guest guest]

Thanks, Marty for what you said. I under stand a little more about

genotypes. Their is just so much to keep up with. You put it where I

could understand Thank you again Jessie, I do try to live one day at a

time.

EZ-DOES IT

[Guest guest]

Thanks, Marty for what you said. I under stand a little more about

genotypes. Their is just so much to keep up with. You put it where I

could understand Thank you again Jessie, I do try to live one day at a

time.

EZ-DOES IT

[Guest guest]

Thanks, Marty for what you said. I under stand a little more about

genotypes. Their is just so much to keep up with. You put it where I

could understand Thank you again Jessie, I do try to live one day at a

time.

EZ-DOES IT

[Guest guest]

In a message dated 2/6/00 9:33:55 PM Central Standard Time,

byteme@... writes:

<< and the others have been mixed, depending on how they got the virus >>

Hello, can you please explain further on that? I have always thought it

depended on the genotype from the person one got contaminated with. If I'm

understanding what you said correctly, since I'm a 2b, and I got Hep C from

blood transfusions, does that mean that almost every one else who got a

transfusion is a 2b? This doesn't sound right....I think I've missed

something somewhere.

Thanks,

Betty

[Guest guest]

Hi Betty

Got HCV from bood

transfusion during

surger at famous

Los Angeles hospital

in 1980 and I am

genotype " 1b. "

Re: Re: Genotypes

>From: Arkhepcgal@...

>

>In a message dated 2/6/00 9:33:55 PM Central Standard Time,

>byteme@... writes:

>

><< and the others have been mixed, depending on how they got the virus >>

>

>Hello, can you please explain further on that? I have always thought it

>depended on the genotype from the person one got contaminated with. If I'm

>understanding what you said correctly, since I'm a 2b, and I got Hep C from

>blood transfusions, does that mean that almost every one else who got a

>transfusion is a 2b? This doesn't sound right....I think I've missed

>something somewhere.

>Thanks,

>Betty

>

>---------------------------

[Guest guest]

Hi Betty

Got HCV from bood

transfusion during

surger at famous

Los Angeles hospital

in 1980 and I am

genotype " 1b. "

Re: Re: Genotypes

>From: Arkhepcgal@...

>

>In a message dated 2/6/00 9:33:55 PM Central Standard Time,

>byteme@... writes:

>

><< and the others have been mixed, depending on how they got the virus >>

>

>Hello, can you please explain further on that? I have always thought it

>depended on the genotype from the person one got contaminated with. If I'm

>understanding what you said correctly, since I'm a 2b, and I got Hep C from

>blood transfusions, does that mean that almost every one else who got a

>transfusion is a 2b? This doesn't sound right....I think I've missed

>something somewhere.

>Thanks,

>Betty

>

>---------------------------

[Guest guest]

Hi Betty

Got HCV from bood

transfusion during

surger at famous

Los Angeles hospital

in 1980 and I am

genotype " 1b. "

Re: Re: Genotypes

>From: Arkhepcgal@...

>

>In a message dated 2/6/00 9:33:55 PM Central Standard Time,

>byteme@... writes:

>

><< and the others have been mixed, depending on how they got the virus >>

>

>Hello, can you please explain further on that? I have always thought it

>depended on the genotype from the person one got contaminated with. If I'm

>understanding what you said correctly, since I'm a 2b, and I got Hep C from

>blood transfusions, does that mean that almost every one else who got a

>transfusion is a 2b? This doesn't sound right....I think I've missed

>something somewhere.

>Thanks,

>Betty

>

>---------------------------

[Guest guest]

Hi Betty

Got HCV from bood

transfusion during

surger at famous

Los Angeles hospital

in 1980 and I am

genotype " 1b. "

Re: Re: Genotypes

>From: Arkhepcgal@...

>

>In a message dated 2/6/00 9:33:55 PM Central Standard Time,

>byteme@... writes:

>

><< and the others have been mixed, depending on how they got the virus >>

>

>Hello, can you please explain further on that? I have always thought it

>depended on the genotype from the person one got contaminated with. If I'm

>understanding what you said correctly, since I'm a 2b, and I got Hep C from

>blood transfusions, does that mean that almost every one else who got a

>transfusion is a 2b? This doesn't sound right....I think I've missed

>something somewhere.

>Thanks,

>Betty

>

>---------------------------

[Guest guest]

..

[Guest guest]

..

[Guest guest]

Connie, Thank you very much for replying.

& Tom

[Guest guest]

Connie, Thank you very much for replying.

& Tom

[Guest guest]

Hi and welcome to you and your husband. :-), Like you said about the

benefit, yes if you have it, it is good it is Genotype 3. There are others here

who get into the more technical things and will let you know. I just wanted to

say, Welcome to the list and that I will keep my fingers crossed for you and I

wish you Good Luck, Take Care, Connie

bigrigtom1@... wrote:

Hello, My name is and 2 years ago we found out my husband has HCV.

With in the last 2 months he has had an ultrasound, blood work and last week

a liver biopsy. We go to the specialist tomorrow to find out the biopsy

results and what he is a candidate for. He definitely has had this virus for

at least 10 years. We picked up his blood work today to take tomorrow and it

shows he is a Genotype 3a. We have been lurking on the list and we share all

your feelings and concerns with this dreaded virus. Wish us luck tomorrow for

our app. If I am understanding correctly Genotype 3a is to his benefit if

there is such a thing with this virus!

[Guest guest]

Hi and welcome to you and your husband. :-), Like you said about the

benefit, yes if you have it, it is good it is Genotype 3. There are others here

who get into the more technical things and will let you know. I just wanted to

say, Welcome to the list and that I will keep my fingers crossed for you and I

wish you Good Luck, Take Care, Connie

bigrigtom1@... wrote:

Hello, My name is and 2 years ago we found out my husband has HCV.

With in the last 2 months he has had an ultrasound, blood work and last week

a liver biopsy. We go to the specialist tomorrow to find out the biopsy

results and what he is a candidate for. He definitely has had this virus for

at least 10 years. We picked up his blood work today to take tomorrow and it

shows he is a Genotype 3a. We have been lurking on the list and we share all

your feelings and concerns with this dreaded virus. Wish us luck tomorrow for

our app. If I am understanding correctly Genotype 3a is to his benefit if

there is such a thing with this virus!

[Guest guest]

Hi and welcome to you and your husband. :-), Like you said about the

benefit, yes if you have it, it is good it is Genotype 3. There are others here

who get into the more technical things and will let you know. I just wanted to

say, Welcome to the list and that I will keep my fingers crossed for you and I

wish you Good Luck, Take Care, Connie

bigrigtom1@... wrote:

Hello, My name is and 2 years ago we found out my husband has HCV.

With in the last 2 months he has had an ultrasound, blood work and last week

a liver biopsy. We go to the specialist tomorrow to find out the biopsy

results and what he is a candidate for. He definitely has had this virus for

at least 10 years. We picked up his blood work today to take tomorrow and it

shows he is a Genotype 3a. We have been lurking on the list and we share all

your feelings and concerns with this dreaded virus. Wish us luck tomorrow for

our app. If I am understanding correctly Genotype 3a is to his benefit if

there is such a thing with this virus!

[Guest guest]

Hi and welcome to you and your husband. :-), Like you said about the

benefit, yes if you have it, it is good it is Genotype 3. There are others here

who get into the more technical things and will let you know. I just wanted to

say, Welcome to the list and that I will keep my fingers crossed for you and I

wish you Good Luck, Take Care, Connie

bigrigtom1@... wrote:

Hello, My name is and 2 years ago we found out my husband has HCV.

With in the last 2 months he has had an ultrasound, blood work and last week

a liver biopsy. We go to the specialist tomorrow to find out the biopsy

results and what he is a candidate for. He definitely has had this virus for

at least 10 years. We picked up his blood work today to take tomorrow and it

shows he is a Genotype 3a. We have been lurking on the list and we share all

your feelings and concerns with this dreaded virus. Wish us luck tomorrow for

our app. If I am understanding correctly Genotype 3a is to his benefit if

there is such a thing with this virus!

[Guest guest]

Hello: :

Yes, if you are going to have this virus 3a is one of the easier forms

to clear.

I have/had genotype 3a but after 1 year of treatment I'm undetectable for the

last almost two years now. So good luck to you and yours.

Take care,

Les

[Guest guest]

Hello: :

Yes, if you are going to have this virus 3a is one of the easier forms

to clear.

I have/had genotype 3a but after 1 year of treatment I'm undetectable for the

last almost two years now. So good luck to you and yours.

Take care,

Les

[Guest guest]

,

Best of luck at your doctors appt. My son has had the virus for 13 years.

Let me know how you make out with the biopsy report.

in Newport RI

[Guest guest]

,

Best of luck at your doctors appt. My son has had the virus for 13 years.

Let me know how you make out with the biopsy report.

in Newport RI