Fw: [hyperbaricoxygen] Re fMRI for Autism

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Source: Neurocase |

fMRI tracks reductions in repetitive behaviors in autism: Two case studies;

Dichter GS, Sikich L, Mahorney S, Felder JN, Lam KS, -Brown L, Bodfish J;

Neurocase 1-10 (Feb 2010)

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Autism is characterized by abnormal prefrontal brain activation during cognitive

control, a potential biomarker of repetitive behaviors. In this

proof-of-principle study, functional magnetic resonance imaging (fMRI) was used

to examine brain activity during an oddball task in two high-functioning males

with autism before and after 12 weeks of treatment with citalopram, a selective

serotonin reuptake inhibitor. One participant showed marked reductions in

repetitive behaviors whereas the other showed mild worsening. Brain activation

in relevant prefrontal regions increased in only the participant whose

repetitive behavior symptoms improved. These findings suggest that fMRI may

elucidate potential mechanisms of action of targeted autism interventions.

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