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grapefruit seed extract & Phase I Liver Detox

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Nat,

There are substances (drugs, herbs, etc.) that induce or inhibit specific P450

enzymes. There are hundreds of these enzymes but humans have only 50, nine of

which metabolize drugs. Cytochrome P450 enzymes CYP3A4 and CYP2D6 biotransform

(i.e., metabolize/detoxify) more than 70% of the drugs/substances tested. For

example, cigarette smoke induces (speeds up) CYP1A2. Prozac (and many other

SRRIs) inhibit CYP2D6. Grapefruit juice inhibits the CYP3A4 enzyme which can

cause toxic levels of drugs that are also metabolized by CYP3A4 (such as Xanax,

caffeine, codeine, DHEA, erythromycin, Ambien, theophylline, etc.)

As far as I can tell, it doesn't make any sense to say that any substance speeds

up Phase I detox because no substance either affects all the P450 enzymes. Do

you know which of the P450 enzymes is affected by grapefruit seed extract

(active ingredient 'Citricide')? I couldn't find anything with a Google search.

Understanding which P450 enzymes metabolize specific drugs/substances has helped

me to understand my daughter's poor reaction to drugs and other substances.

Many things affect the expression of P450 enzymes (lack of certain vitamins,

iron deficiency, etc.) There are genetic tests for CYP2D6 because some people

lack this enzyme while others have low levels. According to

www.prozactruth.com, this test is used by Drug Companies to screen out

individuals that have non-performing or low levels of CYP2D6 from participating

in drug trials of antidepressants that are metabolized by CYP2D6.

More information at http://www.edhayes.com/startp450.html

Janet McAuley

>I have learned that grapefruit seed extract can affect Phase I of the liver's

detox scheme.

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Posted · Report post

I think GSE might help people with a naturally fast phase I, where the liver

phase II can't keep up. I think a lot of toxins get even more toxic in phase I

and only get less toxic after phase II. Therefore you don't want phase I more

efficient than phase II. Maybe inhibiting CYP3A4 is exactly what benefits some

people.

Just a guess,

Dagmar.

[ ] grapefruit seed extract & Phase I Liver Detox

Nat,

There are substances (drugs, herbs, etc.) that induce or inhibit specific P450

enzymes. There are hundreds of these enzymes but humans have only 50, nine of

which metabolize drugs. Cytochrome P450 enzymes CYP3A4 and CYP2D6 biotransform

(i.e., metabolize/detoxify) more than 70% of the drugs/substances tested. For

example, cigarette smoke induces (speeds up) CYP1A2. Prozac (and many other

SRRIs) inhibit CYP2D6. Grapefruit juice inhibits the CYP3A4 enzyme which can

cause toxic levels of drugs that are also metabolized by CYP3A4 (such as Xanax,

caffeine, codeine, DHEA, erythromycin, Ambien, theophylline, etc.)

As far as I can tell, it doesn't make any sense to say that any substance

speeds up Phase I detox because no substance either affects all the P450

enzymes. Do you know which of the P450 enzymes is affected by grapefruit seed

extract (active ingredient 'Citricide')? I couldn't find anything with a Google

search.

Understanding which P450 enzymes metabolize specific drugs/substances has

helped me to understand my daughter's poor reaction to drugs and other

substances. Many things affect the expression of P450 enzymes (lack of certain

vitamins, iron deficiency, etc.) There are genetic tests for CYP2D6 because

some people lack this enzyme while others have low levels. According to

www.prozactruth.com, this test is used by Drug Companies to screen out

individuals that have non-performing or low levels of CYP2D6 from participating

in drug trials of antidepressants that are metabolized by CYP2D6.

More information at http://www.edhayes.com/startp450.html

Janet McAuley

>I have learned that grapefruit seed extract can affect Phase I of the liver's

detox scheme.

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