Re: Rich and all, re: RBC glut

[Guest guest]

Hi Adrienne,

I came up with normal glutathione too and Rich suggested testing to

see if my glutathione peroxidase enzyme was working properly, and it

wasn't.

Glutathione peroxidase enables glutathione to convert hydrogen

peroxide to water.So even if your glutathione levels are normal you

may not be able to use it effectively if this enzyme isn't working

properly.

Rich also suggested getting the glutathione-s-transferase enzymes

tested. These enzymes helps your liver to detoxify heavy metals and

chemicals.

So if these enzymes aren't working properly you get similar effects to

not having enough glutathione because the glutathione can't be used

effectively.

Hope this makes some sense, please anyone correct me if I have got

this wrong.

BW,

Sheila

>

> I hate to bother anyone,( especially you, Rich), but I am kind of in

a stuck place, now that my test results have come back and my

glutathione level is apparently ok.

> I remember Rich saying there was the possibility that even if GSH is

replete there might be a blockage preventing its use.

> I have tried to research the archive (on my desktop) for this post,

but I am incapable of doing that.

> What sort of block could that be and what would be the work-around?

> Thanks, in advance.

> Adrienne

>

>

[Guest guest]

Sheila, Thanks! with those enzyme names I was able to track it down.

So, where do I get those two things tested? (Was it expensive?)

But even more, what recommendations were you given to correct those problems.

When feasible I like to experiment with the solution rather than spend money for

tests.

Thanks,

Adrienne

Re: Rich and all, re: RBC glut

Hi Adrienne,

I came up with normal glutathione too and Rich suggested testing to

see if my glutathione peroxidase enzyme was working properly, and it

wasn't.

Glutathione peroxidase enables glutathione to convert hydrogen

peroxide to water.So even if your glutathione levels are normal you

may not be able to use it effectively if this enzyme isn't working

properly.

Rich also suggested getting the glutathione-s-transferase enzymes

tested. These enzymes helps your liver to detoxify heavy metals and

chemicals.

So if these enzymes aren't working properly you get similar effects to

not having enough glutathione because the glutathione can't be used

effectively.

Hope this makes some sense, please anyone correct me if I have got

this wrong.

BW,

Sheila

>

> I hate to bother anyone,( especially you, Rich), but I am kind of in

a stuck place, now that my test results have come back and my

glutathione level is apparently ok.

> I remember Rich saying there was the possibility that even if GSH is

replete there might be a blockage preventing its use.

> I have tried to research the archive (on my desktop) for this post,

but I am incapable of doing that.

> What sort of block could that be and what would be the work-around?

> Thanks, in advance.

> Adrienne

>

>

[Guest guest]

Hi Adrienne,

Well I am in the UK, but perhaps you are in the US?

Over here the tests were done at Biolab in London. The glutathione

peroxidase test costs about £19 $13) and I think the glutathione

transferase test was approx £28($19) or you can get it as part of the

toxic screen test which is a fancy sensitive liver test costing about

£58($39).

If you are in the US perhaps someone can chime in here with the info

on labs aand these tests.

If you have low glutathione peroxidase, my doc said it can be due to 3

things,

1. low glutathione - well you've not got that

2. selenium deficiency

3. genetic variants of the enzyme that don't work so well - Rich said

that some of these variants work more efficiently with increased

selenium intake though.

Selenium can be toxic in large doses. I am on 800mcg, this is a high

dose, prescribed by the doc, for 2 months to see how the levels of the

enzyme increase, or not. Then the dose will be reviewed. I don't think

I'd want to carry on at this dose longterm without the docs OK. I

think the recommended max dose is normally about 400mcg. I had been on

200mcg for years but still seem to have been low.

If you read this article http://tinyurl.com/g7dbg

you will see that methylselenomethionine seems to be thought of as

the best form and the easiest for your body to detoxify. Jarrow

(activated selenium), Solaray, Ecological Formulas and Vitamin

Research Products seem to make selenium supplements in that form that

form.

Brazil nuts are also a very good soource of selenium and brazil nut oil.

Sorry I don't know what the treatment would be if you had

glutathione-s-transferase problems.

Do you have lyme?

I case it might be relevent, Rich wrote a post on his theory of how

lyme disease becomes chronic. I can't find the original but you can

read it at message number 106236. If you read it you will see how it

fits in with glutathione peroxidase and selenium.

BW,

Sheila

> >

> > I hate to bother anyone,( especially you, Rich), but I am kind of in

> a stuck place, now that my test results have come back and my

> glutathione level is apparently ok.

> > I remember Rich saying there was the possibility that even if GSH is

> replete there might be a blockage preventing its use.

> > I have tried to research the archive (on my desktop) for this post,

> but I am incapable of doing that.

> > What sort of block could that be and what would be the work-around?

> > Thanks, in advance.

> > Adrienne

> >

> >

[Guest guest]

Hi BW,

Would you tell me where you got your glutathione peroxidase enzyme test?

Thanks.

Edy

Re: Rich and all, re: RBC glut

Hi Adrienne,

I came up with normal glutathione too and Rich suggested testing to

see if my glutathione peroxidase enzyme was working properly, and it

wasn't.

Glutathione peroxidase enables glutathione to convert hydrogen

peroxide to water.So even if your glutathione levels are normal you

may not be able to use it effectively if this enzyme isn't working

properly.

Rich also suggested getting the glutathione-s-transferase enzymes

tested. These enzymes helps your liver to detoxify heavy metals and

chemicals.

So if these enzymes aren't working properly you get similar effects to

not having enough glutathione because the glutathione can't be used

effectively.

Hope this makes some sense, please anyone correct me if I have got

this wrong.

BW,

Sheila

>

> I hate to bother anyone,( especially you, Rich), but I am kind of in

a stuck place, now that my test results have come back and my

glutathione level is apparently ok.

> I remember Rich saying there was the possibility that even if GSH is

replete there might be a blockage preventing its use.

> I have tried to research the archive (on my desktop) for this post,

but I am incapable of doing that.

> What sort of block could that be and what would be the work-around?

> Thanks, in advance.

> Adrienne

>

>

[Guest guest]

Hi Adrienne

This summer I had 2 glutathione tests done by the UK's Biolab:

RBC glutathione:

June 1.47 (ref: 1.7 - 2.6 umol/l)

Sept 1.87

Red cell glutathione-S-transferase:

June 179 (ref: 68 - 167 units)

JMH notes: One discrete enzyme band accounts for 35%

of the total.

Atomic emission analysis of the eluted abnormal enzyme

demonstrates the presence of nickel.

Sept 152

JMH notes: There is a *faint* race of a discrete enzyme band.

? Past exposure to a toxic metal.

The level is too low for identification of the causative

substance (probably a metal).

So in 3 months it appears that my glutathione levels have come up to normal and

the nickel problem that was affecting the glutathione-s-transferase has

significantly reduced. The only changes I've made to my routine that I consider

may be significant are starting Lipoceutical Glutathione and FIR saunas soon

after the first test.

Sue

Adrienne G. wrote:

> Sheila, Thanks! with those enzyme names I was able to track it down.

> So, where do I get those two things tested? (Was it expensive?)

> But even more, what recommendations were you given to correct those

> problems. When feasible I like to experiment with the solution rather

> than spend money for tests.

[Guest guest]

Sue

wot kind of lipoceutical glut do u use? IS it essential GSh or something you

get closer to home ? and wot kind of doses do u use?

Tnx

Louella

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[Guest guest]

Thanks, .

My RBC glutathione is already normal. I am inquiring about testing the enzymes

because I have been told they might inhibit my ability to utilize the

glutathione.

Adrienne

Re: Rich and all, re: RBC glut

Hi Adrienne

This summer I had 2 glutathione tests done by the UK's Biolab:

RBC glutathione:

June 1.47 (ref: 1.7 - 2.6 umol/l)

Sept 1.87

Red cell glutathione-S-transferase:

June 179 (ref: 68 - 167 units)

JMH notes: One discrete enzyme band accounts for 35%

of the total.

Atomic emission analysis of the eluted abnormal enzyme

demonstrates the presence of nickel.

Sept 152

JMH notes: There is a *faint* race of a discrete enzyme band.

? Past exposure to a toxic metal.

The level is too low for identification of the causative

substance (probably a metal).

So in 3 months it appears that my glutathione levels have come up to normal

and

the nickel problem that was affecting the glutathione-s-transferase has

significantly reduced. The only changes I've made to my routine that I

consider

may be significant are starting Lipoceutical Glutathione and FIR saunas soon

after the first test.

Sue

Adrienne G. wrote:

> Sheila, Thanks! with those enzyme names I was able to track it down.

> So, where do I get those two things tested? (Was it expensive?)

> But even more, what recommendations were you given to correct those

> problems. When feasible I like to experiment with the solution rather

> than spend money for tests.

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

[Guest guest]

, I forgot;can you feel any difference?

Adrienne

Re: Rich and all, re: RBC glut

Hi Adrienne

This summer I had 2 glutathione tests done by the UK's Biolab:

RBC glutathione:

June 1.47 (ref: 1.7 - 2.6 umol/l)

Sept 1.87

Red cell glutathione-S-transferase:

June 179 (ref: 68 - 167 units)

JMH notes: One discrete enzyme band accounts for 35%

of the total.

Atomic emission analysis of the eluted abnormal enzyme

demonstrates the presence of nickel.

Sept 152

JMH notes: There is a *faint* race of a discrete enzyme band.

? Past exposure to a toxic metal.

The level is too low for identification of the causative

substance (probably a metal).

So in 3 months it appears that my glutathione levels have come up to normal

and

the nickel problem that was affecting the glutathione-s-transferase has

significantly reduced. The only changes I've made to my routine that I

consider

may be significant are starting Lipoceutical Glutathione and FIR saunas soon

after the first test.

Sue

Adrienne G. wrote:

> Sheila, Thanks! with those enzyme names I was able to track it down.

> So, where do I get those two things tested? (Was it expensive?)

> But even more, what recommendations were you given to correct those

> problems. When feasible I like to experiment with the solution rather

> than spend money for tests.

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

[Guest guest]

Hi Adrienne and Louella

It's called Lipoceutical Glutathione and I take a small teaspoon-full most days.

This is it:

www.gshnow.com

I'm brighter and have slightly more energy. My CFS doc says it takes time for

the body to heal so she expects improvements to come over a period of

(unspecified) time. This year I've also managed to bring SODase into normal

range so I should be seeing some benefits some time soon.

Sue

Adrienne G. wrote:

> , I forgot;can you feel any difference?

louella wrote:

> wot kind of lipoceutical glut do u use?

[Guest guest]

Hi Sue,

Did you have to work up to the daily dose of EG? Did you have any adverse

reactions, such as flu-like symptoms?

About the SOD...what is the test for that, and what did you do to raise it?

Have you addressed catalase, another enzyme contributing to mitochondia

function?

Thanks!

Katrina

> > wot kind of lipoceutical glut do u use?

>

[Guest guest]

Sheila,

Thank you! Astonishing how much cheaper your tests seem. I am indeed in USA.

Thank you for the thoroughness of your response. I will study it- and go back on

selenium. I don't recall that using it made a noticeable difference, but maybe I

didn't use it long enough. Will talk to my doc about it.

For some time I was eating brazil nuts regularly, but then my assistant quit and

could not prepare them. Due to tooth problems I was eating them as part of home

made pesto, (instead of pinon nuts.) And I made it with cilantro instead of

basil, so with the garlic it was a very healthy concoction. I suppose I could

even try it with coconut oil instead of the olive oil. The Italians would not

recognise it, but so what.

Adrienne

Re: Rich and all, re: RBC glut

Hi Adrienne,

Well I am in the UK, but perhaps you are in the US?

Over here the tests were done at Biolab in London. The glutathione

peroxidase test costs about £19 $13) and I think the glutathione

transferase test was approx £28($19) or you can get it as part of the

toxic screen test which is a fancy sensitive liver test costing about

£58($39).

If you are in the US perhaps someone can chime in here with the info

on labs aand these tests.

If you have low glutathione peroxidase, my doc said it can be due to 3

things,

1. low glutathione - well you've not got that

2. selenium deficiency

3. genetic variants of the enzyme that don't work so well - Rich said

that some of these variants work more efficiently with increased

selenium intake though.

Selenium can be toxic in large doses. I am on 800mcg, this is a high

dose, prescribed by the doc, for 2 months to see how the levels of the

enzyme increase, or not. Then the dose will be reviewed. I don't think

I'd want to carry on at this dose longterm without the docs OK. I

think the recommended max dose is normally about 400mcg. I had been on

200mcg for years but still seem to have been low.

If you read this article http://tinyurl.com/g7dbg

you will see that methylselenomethionine seems to be thought of as

the best form and the easiest for your body to detoxify. Jarrow

(activated selenium), Solaray, Ecological Formulas and Vitamin

Research Products seem to make selenium supplements in that form that

form.

Brazil nuts are also a very good soource of selenium and brazil nut oil.

Sorry I don't know what the treatment would be if you had

glutathione-s-transferase problems.

Do you have lyme?

I case it might be relevent, Rich wrote a post on his theory of how

lyme disease becomes chronic. I can't find the original but you can

read it at message number 106236. If you read it you will see how it

fits in with glutathione peroxidase and selenium.

BW,

Sheila

> >

> > I hate to bother anyone,( especially you, Rich), but I am kind of in

> a stuck place, now that my test results have come back and my

> glutathione level is apparently ok.

> > I remember Rich saying there was the possibility that even if GSH is

> replete there might be a blockage preventing its use.

> > I have tried to research the archive (on my desktop) for this post,

> but I am incapable of doing that.

> > What sort of block could that be and what would be the work-around?

> > Thanks, in advance.

> > Adrienne

> >

> >

[Guest guest]

Hi Katrina

I had no adverse reaction to the glutathione and started at one teaspoon.

Interesting point though, I hadn't thought about it.

The SODase test was done by Biolab but the solution to the problem was to take

copper (1mg) at breakfast, manganese (5mg) at lunch and zinc (30mg) before bed.

Simple and effective.

I haven't looked at catalase.

BW

Sue

kattemayo wrote:

> Did you have to work up to the daily dose of EG? Did you have any

> adverse reactions, such as flu-like symptoms?

>

> About the SOD...what is the test for that, and what did you do to raise it?

>

> Have you addressed catalase, another enzyme contributing to mitochondia

> function?

[Guest guest]

Hi Adrienne,

Sorry I converted the £/$ the wrong way round! So the tests over here

aren't as cheap !

eg glutathione $36

glutathuione peroxidase $53

toxic screen test $108

Sorry about that, my brain is " programmed " for changing dollars into

pounds for buying supplements from the US, not the other way round!

BW,

Sheila

> > >

> > > I hate to bother anyone,( especially you, Rich), but I am

kind of in

> > a stuck place, now that my test results have come back and my

> > glutathione level is apparently ok.

> > > I remember Rich saying there was the possibility that even

if GSH is

> > replete there might be a blockage preventing its use.

> > > I have tried to research the archive (on my desktop) for

this post,

> > but I am incapable of doing that.

> > > What sort of block could that be and what would be the

work-around?

> > > Thanks, in advance.

> > > Adrienne

> > >

> > >

[Guest guest]

No problem! Still sounds extremely cheap to me! RBC glutathione was I think, $75

last month.

Adrienne

Re: Rich and all, re: RBC glut

Hi Adrienne,

Sorry I converted the £/$ the wrong way round! So the tests over here

aren't as cheap !

eg glutathione $36

glutathuione peroxidase $53

toxic screen test $108

Sorry about that, my brain is " programmed " for changing dollars into

pounds for buying supplements from the US, not the other way round!

BW,

Sheila

> > >

> > > I hate to bother anyone,( especially you, Rich), but I am

kind of in

> > a stuck place, now that my test results have come back and my

> > glutathione level is apparently ok.

> > > I remember Rich saying there was the possibility that even

if GSH is

> > replete there might be a blockage preventing its use.

> > > I have tried to research the archive (on my desktop) for

this post,

> > but I am incapable of doing that.

> > > What sort of block could that be and what would be the

work-around?

> > > Thanks, in advance.

> > > Adrienne

> > >

> > >