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Re: new mab: blinatumomab

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Posted · Report post

Blinatumomab is a new monoclonal antibody that is directed against CD3 (on T

cells) and CD19 (on B cells). The idea is to bring the B cells in proximity to

T cells so the T cells can " prime " and immune response against the B cells.

This antibody is very early in clinical development. I am not aware of any

clinical trials at this time studying the antibody.

Rick Furman, MD

>

> Hello fellow CLL/SLL,

>

> Are any of you aware of the new monclonal antibody technology's blinatumomab?

>

> Any comments on this new dual antibody technology or the clinical trials

investigating this?

>

> Merle, Cochranton, PA,

> dx 11-13-01 sll IIIbe grade 1

> at 52yrs with hypercalcimia

> 6 x chop & 8 x rituxan cmplt'd 4-11-02 with Complete Response

> vincristine neuropathy 3-18-02

> false neg. PET 8-12-02 pos.node biopsy 9-5-02

> 75 mo.PFS, reoccurance 10-10-08

> watch & learn, onc appt: 9-15-10

>

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Posted · Report post

MT 103 ( blinatumomab) This has been around since 2004. No CLL trials, just one

for NHL which will end this year (NCT00274742)

There are a couple of new CD19 mAbs in the works one of note is MOR208 (aka

XmAb5574)

Link Here: http://www.morphosys.com/node/2168

~chris

http://cllcanada.ca

>

> Hello fellow CLL/SLL,

>

> Are any of you aware of the new monclonal antibody technology's blinatumomab?

>

> Any comments on this new dual antibody technology or the clinical trials

investigating this?

>

> Merle, Cochranton, PA,

> dx 11-13-01 sll IIIbe grade 1

> at 52yrs with hypercalcimia

> 6 x chop & 8 x rituxan cmplt'd 4-11-02 with Complete Response

> vincristine neuropathy 3-18-02

> false neg. PET 8-12-02 pos.node biopsy 9-5-02

> 75 mo.PFS, reoccurance 10-10-08

> watch & learn, onc appt: 9-15-10

>

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