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Re: new mab: blinatumomab

1 reply to this topic      (45 views)

#1 *guest

*guest
  • Guests

Posted 13 July 2010 - 04:45 PM

Blinatumomab is a new monoclonal antibody that is directed against CD3 (on T
cells) and CD19 (on B cells). The idea is to bring the B cells in proximity to
T cells so the T cells can " prime " and immune response against the B cells.
This antibody is very early in clinical development. I am not aware of any
clinical trials at this time studying the antibody.

Rick Furman, MD


>
> Hello fellow CLL/SLL,
>
> Are any of you aware of the new monclonal antibody technology's blinatumomab?
>
> Any comments on this new dual antibody technology or the clinical trials
investigating this?
>
> Merle, Cochranton, PA,
> dx 11-13-01 sll IIIbe grade 1
> at 52yrs with hypercalcimia
> 6 x chop & 8 x rituxan cmplt'd 4-11-02 with Complete Response
> vincristine neuropathy 3-18-02
> false neg. PET 8-12-02 pos.node biopsy 9-5-02
> 75 mo.PFS, reoccurance 10-10-08
> watch & learn, onc appt: 9-15-10
>

#2 *guest

*guest
  • Guests

Posted 13 July 2010 - 04:47 PM

MT 103 ( blinatumomab) This has been around since 2004. No CLL trials, just one
for NHL which will end this year (NCT00274742)

There are a couple of new CD19 mAbs in the works one of note is MOR208 (aka
XmAb5574)

Link Here: http://www.morphosys.com/node/2168

~chris
http://cllcanada.ca






>
> Hello fellow CLL/SLL,
>
> Are any of you aware of the new monclonal antibody technology's blinatumomab?
>
> Any comments on this new dual antibody technology or the clinical trials
investigating this?
>
> Merle, Cochranton, PA,
> dx 11-13-01 sll IIIbe grade 1
> at 52yrs with hypercalcimia
> 6 x chop & 8 x rituxan cmplt'd 4-11-02 with Complete Response
> vincristine neuropathy 3-18-02
> false neg. PET 8-12-02 pos.node biopsy 9-5-02
> 75 mo.PFS, reoccurance 10-10-08
> watch & learn, onc appt: 9-15-10
>



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