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Gello way down this paper they talk about body odor-- Ann

Physical Health in Autism

Woody R. McGinnis M.D.

Irene (Vicky) Colquhoun

1920-2000

Parent Pioneers

Bernard Rimland

Ellen Bolte

O'Reilly

Beck

Rik Rollens

The Mercury Team

Autism and ADHD are Symptoms

Multiple underlying problems

Variation and commonality

Gut and nutrition paramount

Cornerstones

Suboptimal Nutrition

Food Intolerances

Microbial Overgrowths

Toxins

Gut Disease Predominates

Esophagitis 69%

Gastritis 42%

Duodenitis 67%

Colitis 88%

Esophagitis with Ulceration

Duodenitis with Ulceration

Distal Ileal LNH

Distal Ileal LNH

Colonic LNH

Autistic Colitis

Autistic Gut Symptoms

Abdominal pain 69%

Chronic diarrhea 58%

Constipation 35%

Night-awakening 42%

Gut Status

Poor digestion and absorption

Leaky gut: proteins out, toxins and antigens in

Microbial overgrowths

Poor enzyme production

Altered signaling to CNS

Gut Dysfunction

Poor Acid Production

Reasons: low zinc, endotoxins,

peptides, acidosis and mercury

Effects: poor digestion and poor

infection control

Autism Viewed from the Gut

Casein/gluten-free diets

The key peptidase (DPPIV) is produced by the intestinal brush border

and paneth cells

The Gut and…

Secretin

Made by intestine

Stimulates digestive enzymes

Increases blood flow to intestine

Increases immune levels in bile

Tightens leaky gut

The Gut and..

IVIG, Transfer Factor and

Anti-viral Agents

May suppress chronic intestinal

infection, or even an intestinal

autoimmune process.

The Gut and…

DMSA / Lipoic Acid

Mercury and cadmium avidly bind intestine

and are highly caustic

Mercury blocks vitamin B6 and DPPIV

in the gut

Antibiotic-altered flora may recirculate mercury

to the gut

The Gut and…

Bethanecol

Trophic to intestinal mucosa

Stimulates digestive enzymes and

paneth cells which release defensins

to control overgrowths

Helps acid production and reflux

The Gut and…

Cod liver oil

Vitamin A supports GI membranes and

resistance to infection, especially measles

EPA (a derivative omega-3) is a potent

anti-inflammatory, lowers oxidative

stress

The Gut and…

Zinc

Protects all membranes from free

radicals

Tightens leaky gut

Needed for acid production

Critical protection from infection

DAN Think-Tank 2000

Hallmark Pilot Study: Nutritional Status of Autistic Children

(Audya and Vogelaar)

Sensitive assays

Low Nutrient Levels

Other Key Deficiencies

Magnesium often low by red blood-cell measurement

Calcium low by urinary excretion

Membrane Fatty Acids

Very Low Sulfate

Rosemary Waring discovery

Sulfate only 20%

Poor sulfate production

Greater sulfate utilization

Low Functional Levels

Biotin 14 of 15 children

B12 6 of 15 children

Folate 5 of 13 children

B6 binding low in nearly all

Laboratory Indices of Vitamin and Mineral Deficiency in Autism

Defeat Autism Now

27 October 2002

San Diego

Tapan Audhya Ph.D., Vitamin Diagnostics

Emar Vogelaar Ph.D., European Laboratory of Nutrients

Low Nutrient Levels in Autism (187 Autistic, 11-16 y.o vs. 10-17

y.o. controls)

Low Nutrient Levels in Autism

Low Nutrient Levels in Autism 187 Autistics (11-16 y.o.) v. Controls

(10-17 y.o.)

Low Nutrient Levels in Autism

Low Minerals in Autism

Environmental Toxins in Autism?

Some Clues:

D-glucaric acid increased in 78%

Low plasma glutathione levels:

lower range in autism (1.2-4.1 micromoles/ml v. 3.8-5.5 in controls)

46% autistics below normal

Elevated Toxins in Autism

(41 autistics, 24 controls)

Toxins in Autism

Organic Toxins in Autism

Organic Toxins in Autism

Oxidative Stress

Low anti-oxidant levels: Vitamin A,

Vitamin C, Zinc, Selenium, Taurine

Weak hepatic detoxification

Greater toxic burdens

Good response to antioxidants

Especially Sensitive to Oxidative Stress

Gut: extreme sensitivity of gastrointestinal mucosa to free-radicals

Brain: high lipid, low GSH, low metallothionein levels

Goal: Lessen Oxidative Stress

Minimize toxins, infections, allergens

Give plenty of anti-oxidants

Support detoxification metabolism:

Vitamins B6, B12, (Folate)

Magnesium, Zn, Selenium (folic acid)

(Methionine)

Poor Immunity

Low CD20+ (B-cells) 48%

Low NK-cell function 40%

Low CD4+ (T-cells) 28%

Poor T-cell function p<.001

Low IgG sub and IgA 20%

C4A null allele 57%

Absent vaccine titers 5/13

Autoimmunity in Autism

Familial: mothers X 8

Anti-MBP/NFP/GFAP 58/55/32%

IgM to brain nuclear / endo 36%

Antibody to 7 neuronal proteins

MBP macrophage inhibition 77 v 0%

Basolateral IgG + complement

CD8+ infiltration L.P. and epith.

Anti-MMR, (only measles) 65 v 0%

Nutrients and Autoimmunity

Low Vit A: increased IgM in experimental

murine autoimmunity (PubMed 6609978)

Experimental T-cell autoimmunity: EFA

deficiency or omega-3 supplementation

increased autoimmunity; omega-6

protective in both T-cell and Ab-

mediated autoimmunity

(PubMed 10096116)

Treatment

Supplements

Food avoidance

Suppress overgrowths

Detoxify

Really Key Nutrients

Zinc

Magnesium

Calcium

Vitamin B6

Fatty Acids

Vitamin A

Vitamin C

Vitamin E

Vitamin B12

Biotin

Supplementation

History, physical, lab, empirical

Don't be deceived: use sensitive measurements

Keep re-checking to confirm

Changing needs and variability

Rules-of-Thumb

Introduce interventions individually

Smaller doses may be necessary, especially at first

Continue interventions unless reason to stop

If combination nutritional formulations are not well-tolerated, add

one-at-a-time

One-at-a-Time

Build sequentially

Zinc, then P5P/Magnesium Glycinate, Calcium, Selenium, C, E, Multi-

Vit without Copper, Biotin, B12, Cod liver oil (for Vitamin A)

Really assure zinc

Away from food, minerals and P5P Zinc/Manganese about 3:1

Fatty-Acid Basics

Pre-treat with anti-oxidants

Treat low-normal GLA, DGLA and EPA lab values

Dry hair or skin, allergy: usually need fish oil EPA

Infections, leaky gut: usually need evening primrose GLA

Other Great Nutrients

MSM for elemental sulfur

Taurine for bile and for brain

Glutamine

Preferred energy for the gut

Trophic to bowel and mucin

Improves gut immunity

Careful if high ammonia

Support Digestion

Full digestive enzymes,

including disaccharidases

Frequent feeding, stews, amino acid

formulations, bethanecol

Break the inflammatory cycle: avoid

IgG and IgE foods.

Suppress overgrowths. EPA,

gastrocrom, anti-oxidants

Food Intolerances

Urinary Peptides or empiric trial of

casein/gluten-free

IgG blood-test for food allergies. Add

IgE test if conventional allergies.

Shiners, red cheeks/ears, teeth-

grinding, bed-wetting, ear or

sinus infections, mood swings

Lactose, sugar and phenolic

intolerances by observation

Probiotics Always

Improve overgrowths, digestion, membrane integrity

Refrigeration is vital

O.K to mix-and-match

Lactobacillus GG for clostridia

Could aggravate acidosis

Gut Overgrowths

Get specialized studies: parasites, stool cultures and organic acids

Antifungals, probiotics and colostrum often needed long-term

Low-glycemic diet, digestive enzymes, evening primrose oil, zinc and

cod liver oil all help

Promising: IVIG, TF

Urinary Pyrroles

Useful, economical, may be pivotal.

Very toxic. Microbes or Pollution?

Elevation makes zinc and Vitamin B6

a top priority

Careful handling instructions: highly

labile

" Mauve Factor " Means Pyrroles

Measurable in urine as Kryptopyrrole

Mono-pyrrole

structure

Pyrroluria is

treatable:

B6 and Zinc

Mauve Factor

Down Syndrome 70%

Schizophrenia 50-60%

Autism 30-50%

ADHD 30%

Also Mental Retardation, Depression, Alcoholism, and Delinquency

Strong familial tendency

The Mauve Factor

Elevated pyrroles imply:

Zinc and B6 deficits, which vary individually and which fluctuate

Poor stress tolerance

Pfeiffer's Correlates

Zinc spots

Stretch marks

Pale Skin

Frequent URI's

Food intolerances

Breath / body odor

Mood swings

Morning nausea

Upper abd. pain

Poor dream recall

Substrate Requirement for Maximal Activity of P5P Dependent Enzymes

Walsh's Correlates

Zinc spots

Fair complexion

Poor breakfast-eater

Low stress tolerance

Hyperactivity

Light, sound, odors

Stitch in side

Excessive anxiety or pessimism

Absent or poor dream recall

Explosive temper

Pyrrole Primer

Levels correlate reasonably well with many symptoms

Zinc supplementation lowers measured pyrrole levels (Hoffer)

B6 supplementation lowers measured pyrrole levels (McCabe)

Unstable: ascorbate preservative; avoid light, heat, delays

Sufficient Zn and B6 keep down pyrroles

The Pyrrole Family

Pyrrole-Zn-P5P Complex

P5P-Dependent Enzymes

Pharmacokinetics of Vitamin B6 and P5P in Autistic and Control

Children

Pyridoxal Kinase Activity

Substrate Requirement for Maximal Activity of P5P Dependent Enzymes

Mauve Factor Levels and B6 (10mg/kg/day) + Zn (25mg) + Mg (400mg) in

Autism

Detoxification

Organic foods, pure water

Clean living environment

No additives or flavor enhancers

Regular bowel movements: fiber, mag-citrate, vitamin C, bethanecol

Plug nutritional holes and suppress overgrowths

DMSA / Lipoic Acid metals protocol

Basic Lab List

Stool parasites, culture, analysis

Organic acids

Urine pyrroles

Hair analysis

Serum IgG / IgE food allergy

RBC minerals

Amino acids

Peptides

RBC fatty acids

Vitamin levels

Viral and auto- immune titers

PCR for mycopl. and chlamydia

Toxin testing

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> My 8 yr old is severely autistic & not potty trained, so there's

often a

> smell about him when he needs changing . However, lately he's had

more of a

> body odor smell. It's different. We had finished round 10 about a

month ago

> but I'm taking a long break as things were getting too difficult,

probably

> from yeast/bacteria or something. I'm going to try getting him

started on

> Primal Defense this week. He's GFCF. What else could be causing

this odor?

> (he's too young for puberty ... will turn 9 in sept).

>

> Thanks,

> Michele

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My child starts to smell if he does not have a daily BM.

When he does not have daily BMs it is usually because

yeast and/or bacteria are overgrowing. It might be a

gut bug issue.

[ ] Body Odor

> My 8 yr old is severely autistic & not potty trained, so there's often a

> smell about him when he needs changing . However, lately he's had more of

a

> body odor smell. It's different. We had finished round 10 about a month

ago

> but I'm taking a long break as things were getting too difficult, probably

> from yeast/bacteria or something. I'm going to try getting him started on

> Primal Defense this week. He's GFCF. What else could be causing this odor?

> (he's too young for puberty ... will turn 9 in sept).

>

> Thanks,

> Michele

>

>

> =======================================================

>

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Hi Michele,

I would be very careful about the use of deodorants. I believe most of the have

some sort of aluminium compound in them.

All the best,

Dagmar.

he needs deodorant

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Sometimes detoxing metals can cause what I describe as a " gun powder " odor.

Kids who eat animal products are starting puberty very early these days, due to

the hormones used in animals. Any new supplements? Some of those may add an

odor.

S

<tt>

My 8 yr old is severely autistic & not potty trained, so there's often a <BR>

smell about him when he needs changing . However, lately he's had more of a <BR>

body odor smell. It's different. We had finished round 10 about a month ago <BR>

but I'm taking a long break as things were getting too difficult, probably <BR>

from yeast/bacteria or something. I'm going to try getting him started on <BR>

Primal Defense this week. He's GFCF. What else could be causing this odor? <BR>

(he's too young for puberty ... will turn 9 in sept).<BR>

<BR>

Thanks,<BR>

Michele<BR>

</tt>

=======================================================<BR>

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> My 8 yr old is severely autistic & not potty trained, so there's

often a

> smell about him when he needs changing . However, lately he's had

more of a

> body odor smell. It's different.

This is bacteria for my son.

Dana

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Yes,

I think my implants caused me to sweat so much more than usual. I noticed that.

Deb

kimp885 <kimp885@...> wrote:

has anyone found anything on body odor and implants. could something in the shell becasuing the odor. also could the sweating excessive be my body trying to rid itself of the implants bateria. i know they say sweating is a way of relasing toxins so could my body be trying to get the toxins from the implant out????????/

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Kim,

Pamela Stott-Kendall wrote a book called "Torn Illusions" about her breast implant experience. In it, she told how she continually struggled with a horrible body odor from her implants, to the point of it ruining her clothes and bedding. You might want to read her book. It is full of valuable information, and of course, a tragic story of how implants ruined her life.

Patty

----- Original Message -----

From: kimp885

Sent: Wednesday, February 25, 2004 12:28 PM

Subject: body odor

has anyone found anything on body odor and implants. could something in the shell becasuing the odor. also could the sweating excessive be my body trying to rid itself of the implants bateria. i know they say sweating is a way of relasing toxins so could my body be trying to get the toxins from the implant out????????/

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did you always feel hot and was there an odor? how is the sweating

now yhat they are gone?

> has anyone found anything on body odor and implants. could

something

> in the shell becasuing the odor. also could the sweating excessive

> be my body trying to rid itself of the implants bateria. i know

they

> say sweating is a way of relasing toxins so could my body be

trying

> to get the toxins from the implant out????????/

>

>

>

>

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Kim, I have the book, but I am not able to scan the page....I'll just have to type it out. It is quite extensive in the discussions of the many symptoms she had...my suggestion is to just get the book and read it for yourself so you can get the whole picture. She fought a valiant fight. Here is that part of her story starting on page 20. Note: was her maid.

"Another blow struck in the summer of 1984. and I noticed a slight chemical odor in my clothing. We were at a loss to determine its origin, since never used bleach and washed with mild detergents when laundering the clothes. Dr. Droller was just as baffled and suggested a change in laundry products. Although we changed to other brands of detergent, the chemical odor, tainting my clothing, did not lessen and grew even more disconcerting. Next, I began having difficulty breathing. Dr. Droller prescribed antibiotics, but the respiratory symptoms did not improve, only worsened. One problem came after another. Soon, I developed dry eye syndrome. An opthamologist, Dr. Redfern, diagnosed the disorder after administering a Schirmer tear test; he described this syndrome as irreversible and immune-system related. Other symptoms surfaced. Now I suffered dizzy spells with daily, excruciating headaches. The nagging pain in my upper-left abdominal area sharpened, and allergic reactions to environmental chemicals increased.

By early fall, on the threshold of my fifth year after the implants, the chemical odor had become very pungent and quite noticeable as it accumulated in the upper-body areas of my clothing. Though tried, washing the clothes vigorously would not eliminate the odor. Then I started having drenching night sweats. To my horror, they bleached the color out of my bed linens. was alarmed, and I was totally devastated. Completely defeated and despondent over the development of this new and horrifying symptom, I had further lost faith in my physician's ability to help me.

As the chemical stench steadily intensified, I became more and more frightened about the possible outcome of my disease. The odor got stronger; I got weaker. I began to think that I was about to die.

My children were not spared either. They were eyewitnesses to the personal horror growing in my life. Daily, they watched removed the reeking, stained clothes and linens from my bedroom. Many of them had to be thrown away with the trash."

From "Torn Illusions" by Pamela Stott-Kendall,

1994 Debcar Publishing, Fort Lauderdale, FL

----- Original Message -----

From: kimp885

Sent: Thursday, February 26, 2004 3:24 PM

Subject: Re: body odor

does anyone here have the book and can scan the page. i would love to show it to my ps? does she mention dry eyes?

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does anyone know how her symptoms are afrer explant?

--- In , " ~*Patty*~ " <redeemed7@c...>

wrote:

> Kim, I have the book, but I am not able to scan the page....I'll

just have to type it out. It is quite extensive in the discussions

of the many symptoms she had...my suggestion is to just get the book

and read it for yourself so you can get the whole picture. She

fought a valiant fight. Here is that part of her story starting on

page 20. Note: was her maid.

>

> " Another blow struck in the summer of 1984. and I noticed

a slight chemical odor in my clothing. We were at a loss to

determine its origin, since never used bleach and washed with

mild detergents when laundering the clothes. Dr. Droller was just

as baffled and suggested a change in laundry products. Although we

changed to other brands of detergent, the chemical odor, tainting my

clothing, did not lessen and grew even more disconcerting. Next, I

began having difficulty breathing. Dr. Droller prescribed

antibiotics, but the respiratory symptoms did not improve, only

worsened. One problem came after another. Soon, I developed dry

eye syndrome. An opthamologist, Dr. Redfern, diagnosed the

disorder after administering a Schirmer tear test; he described this

syndrome as irreversible and immune-system related. Other symptoms

surfaced. Now I suffered dizzy spells with daily, excruciating

headaches. The nagging pain in my upper-left abdominal area

sharpened, and allergic reactions to environmental chemicals

increased.

>

> By early fall, on the threshold of my fifth year after the

implants, the chemical odor had become very pungent and quite

noticeable as it accumulated in the upper-body areas of my

clothing. Though tried, washing the clothes vigorously would

not eliminate the odor. Then I started having drenching night

sweats. To my horror, they bleached the color out of my bed linens.

was alarmed, and I was totally devastated. Completely

defeated and despondent over the development of this new and

horrifying symptom, I had further lost faith in my physician's

ability to help me.

>

> As the chemical stench steadily intensified, I became more and

more frightened about the possible outcome of my disease. The odor

got stronger; I got weaker. I began to think that I was about to

die.

>

> My children were not spared either. They were eyewitnesses to the

personal horror growing in my life. Daily, they watched

removed the reeking, stained clothes and linens from my bedroom.

Many of them had to be thrown away with the trash. "

>

> From " Torn Illusions " by Pamela Stott-Kendall,

> 1994 Debcar Publishing, Fort Lauderdale, FL

> ----- Original Message -----

> From: kimp885

>

> Sent: Thursday, February 26, 2004 3:24 PM

> Subject: Re: body odor

>

>

> does anyone here have the book and can scan the page. i would

love

> to show it to my ps? does she mention dry eyes?

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No never had odor, but I would have hot flashes with sweating. It just seemed like I sweat 10 times easier than prior to implants. Now that they are out it seems to have let up some. I won't really be able to tell until weather gets warmer. I do think it has made a bif difference in getting them out.

My skin also is less hypersensitive all over.

Debkimp885 <kimp885@...> wrote:

did you always feel hot and was there an odor? how is the sweating now yhat they are gone?> has anyone found anything on body odor and implants. could something > in the shell becasuing the odor. also could the sweating excessive > be my body trying to rid itself of the implants bateria. i know they > say sweating is a way of relasing toxins so could my body be trying > to get the toxins from the implant out????????/> > > >

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---

You have probably already thought of this, but hyperthyroid,

autoimmune Grave's Disease can cause heat intolerance and excessive

sweating among other things...

In , " kimp885 " <kimp885@y...> wrote:

> did you always feel hot and was there an odor? how is the sweating

> now yhat they are gone?

>

> > has anyone found anything on body odor and implants. could

> something

> > in the shell becasuing the odor. also could the sweating

excessive

> > be my body trying to rid itself of the implants bateria. i know

> they

> > say sweating is a way of relasing toxins so could my body be

> trying

> > to get the toxins from the implant out????????/

> >

> >

> >

> >

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I use a deodorant stone which works well and lasts a long time.

Suzi <k_frog100@...> wrote:

Why would I want to use Suave deodorant when it has some really nasty unhealthy stuff in it?

Try Nature's Gate Organics. Works great for me and I am a very active, hard working farm girl.

Kim

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